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Genome Editing for Engineering the Next Generation of Advanced Immune Cell Therapies
Our current genetic engineering capacity through synthetic biology and genome editing is the foundation of a revolution in biomedical science: the...
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Partial recovery of disturbed V-J pairing profiles of T-cell receptor in people living with HIV receiving long-term antiretroviral therapy
Chronic human immunodeficiency virus (HIV) infection not only causes a gradual loss of CD4 + T cells but also leads to a disturbance of the T cell...
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Single-cell T cell receptor sequencing of paired human atherosclerotic plaques and blood reveals autoimmune-like features of expanded effector T cells
Atherosclerosis is a lipid-driven chronic inflammatory disease; however, whether it can be classified as an autoimmune disease remains unclear. In...
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Multimodal immunogenomic biomarker analysis of tumors from pediatric patients enrolled to a phase 1-2 study of single-agent atezolizumab
We report herein an exploratory biomarker analysis of refractory tumors collected from pediatric patients before atezolizumab therapy...
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Spontaneous tumor regression mediated by human T cells in a humanized immune system mouse model
Immunodeficient mice reconstituted with a human immune system (HIS mice) give rise to human T cells, which make them an attractive system to study...
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Tasmanian devils with contagious cancer exhibit a constricted T-cell repertoire diversity
The Tasmanian devil ( Sarcophilus harrisii ) is threatened by a contagious cancer, known as Devil Facial Tumour Disease (DFTD). A highly diverse T-cell...
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K2P18.1 translates T cell receptor signals into thymic regulatory T cell development
It remains largely unclear how thymocytes translate relative differences in T cell receptor (TCR) signal strength into distinct developmental...
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Subsequent malaria enhances virus-specific T cell immunity in SIV-infected Chinese rhesus macaques
BackgroundCoinfection with HIV and Plasmodium parasites is fairly common, but the sequence of infection with these two pathogens and their impact on...
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Comprehensive analysis of neoantigens derived from structural variation across whole genomes from 2528 tumors
BackgroundNeoantigens are critical for anti-tumor immunity and have been long-envisioned as promising therapeutic targets. However, current...
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RNase H–dependent PCR-enabled T-cell receptor sequencing for highly specific and efficient targeted sequencing of T-cell receptor mRNA for single-cell and repertoire analysis
RNase H–dependent PCR-enabled T-cell receptor sequencing (rhTCRseq) can be used to determine paired alpha/beta T-cell receptor (TCR) clonotypes in...
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Comparative immunological landscape between pre- and early-stage LUAD manifested as ground-glass nodules revealed by scRNA and scTCR integrated analysis
BackgroundMechanism underlying the malignant progression of precancer to early-stage lung adenocarcinoma (LUAD) as well as their indolence nature...
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IgMAT: immunoglobulin sequence multi-species annotation tool for any species including those with incomplete antibody annotation or unusual characteristics
BackgroundThe advent and continual improvement of high-throughput sequencing technologies has made immunoglobulin repertoire sequencing accessible...
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scBCR-seq revealed a special and novel IG H&L V(D)J allelic inclusion rearrangement and the high proportion dual BCR expressing B cells
Since the initial report of V (D) J “allelic exclusion/inclusion” (allelic exclusion rearrangement or allelic inclusion rearrangement) and the...
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Current advancements in B-cell receptor sequencing fast-track the development of synthetic antibodies
Synthetic antibodies (Abs) are a class of engineered proteins designed to mimic the functions of natural Abs. These are produced entirely in vitro,...
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Definitive hematopoietic stem/progenitor cells from human embryonic stem cells through serum/feeder-free organoid-induced differentiation
BackgroundEx vivo production of hematopoietic stem/precursor cells (HSPCs) represents a promising versatile approach for blood disorders.
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Balancing sensitivity and specificity in distinguishing TCR groups by CDR sequence similarity
BackgroundRepertoire sequencing is enabling deep explorations into the cellular immune response, including the characterization of commonalities and...
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ISG20L2: an RNA nuclease regulating T cell activation
ISG20L2, a 3′ to 5′ exoribonuclease previously associated with ribosome biogenesis, is identified here in activated T cells as an enzyme with a...
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Single-cell profiling of immune cells after neoadjuvant pembrolizumab and chemotherapy in IIIA non-small cell lung cancer (NSCLC)
The combination of immune checkpoint inhibitors (ICIs) with chemotherapy (chemoimmunotherapy) in the neoadjuvant setting have achieved favorable...
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Targeting Intracellular Antigens with pMHC-Binding Antibodies: A Phage Display Approach
Antibodies that bind peptide-MHC (pMHC) complex in a manner akin to T cell receptor (TCR) have not only helped in understanding the mechanism of...