Search
Search Results
-
The Ambivalent Role of lncRNA **st in Carcinogenesis
Long non-coding RNA (lncRNA) **st has emerged as a key modulator in dosage compensation by randomly inactivating one of the X chromosomes in mammals...
-
DNA methylation restricts coordinated germline and neural fates in embryonic stem cell differentiation
As embryonic stem cells (ESCs) transition from naive to primed pluripotency during early mammalian development, they acquire high DNA methylation...
-
Pervasive male-biased expression throughout the germline-specific regions of the sea lamprey genome supports key roles in sex differentiation and spermatogenesis
Sea lamprey undergo programmed genome rearrangement (PGR) in which ∼20% of the genome is jettisoned from somatic cells during embryogenesis. Although...
-
The genetics of gaits in Icelandic horses goes beyond DMRT3, with RELN and STAU2 identified as two new candidate genes
BackgroundIn domesticated animals, many important traits are complex and regulated by a large number of genes, genetic interactions, and...
-
A comprehensive phenotypic characterization of a whole-body Wdr45 knock-out mouse
Pathogenic variants in the WDR45 (OMIM: 300,526) gene on chromosome Xp11 are the genetic cause of a rare neurological disorder characterized by...
-
Generating Sequencing-Based DNA Methylation Maps from Low DNA Input Samples
Reduced representation bisulfite sequencing (RRBS)Reduced representation bisulfite sequencing (RRBS) is a technique used for assessing genome-wide...
-
Optimized bisulfite sequencing analysis reveals the lack of 5-methylcytosine in mammalian mitochondrial DNA
BackgroundDNA methylation is one of the best characterized epigenetic modifications in the mammalian nuclear genome and is known to play a...
-
A powerful parent-of-origin effects test for qualitative traits on X chromosome in general pedigrees
BackgroundGenomic imprinting is one of the well-known epigenetic factors causing the association between traits and genes, and has generally been...
-
Strand asymmetry influences mismatch resolution during single-strand annealing
BackgroundBiases of DNA repair can shape the nucleotide landscape of genomes at evolutionary timescales. The molecular mechanisms of those biases are...
-
Efficient and accurate determination of genome-wide DNA methylation patterns in Arabidopsis thaliana with enzymatic methyl sequencing
Background5′ methylation of cytosines in DNA molecules is an important epigenetic mark in eukaryotes. Bisulfite sequencing is the gold standard of...
-
Misdiagnosis in mucopolysaccharidoses
Mucopolysaccharidosis (MPS) is a group of 13 hereditary metabolic diseases identified in humans (or 14 diseases if considering one MPS type described...
-
Cell Therapy Strategies on Duchenne Muscular Dystrophy: A Systematic Review of Clinical Applications
Duchenne Muscular Dystrophy (DMD) is an inherited genetic disorder characterized by progressive degeneration of muscle tissue, leading to functional...
-
The structure-specific endonuclease complex SLX4–XPF regulates Tus–Ter-induced homologous recombination
Vertebrate replication forks arrested at interstrand DNA cross-links (ICLs) engage the Fanconi anemia pathway to incise arrested forks, ‘unhooking’...
-
Treating Rett syndrome: from mouse models to human therapies
Rare diseases are very difficult to study mechanistically and to develop therapies for because of the scarcity of patients. Here, the rare...
-
Analyses of inter-individual variations of sperm DNA methylation and their potential implications in cattle
BackgroundDNA methylation has been shown to be involved in many biological processes, including X chromosome inactivation in females, paternal...
-
Detection of CRISPR-mediated genome modifications through altered methylation patterns of CpG islands
BackgroundThe development and application of CRISPR technologies for the modification of the genome are rapidly expanding. Advances in the field...
-
Random X-chromosome inactivation dynamics in vivo by single-cell RNA sequencing
BackgroundRandom X-chromosome inactivation (rXCI) is important for the maintenance of normal somatic cell functions in female eutherian mammals. The...
-
Allele-specific RNA-seq expression profiling of imprinted genes in mouse isogenic pluripotent states
BackgroundGenomic imprinting, resulting in parent-of-origin specific gene expression, plays a critical role in mammalian development. Here, we apply...
-
Structural variants shape driver combinations and outcomes in pediatric high-grade glioma
We analyzed the contributions of structural variants (SVs) to gliomagenesis across 179 pediatric high-grade gliomas (pHGGs). The most recurrent SVs...
-
Acquired genetic changes in human pluripotent stem cells: origins and consequences
In the 20 years since human embryonic stem cells, and subsequently induced pluripotent stem cells, were first described, it has become apparent that...
