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Canine visceral leishmaniasis and Rhipicephalus sanguineus: evaluation and comparison of classical techniques
The aim of this study was evaluating the association and correlation between the diagnostics tests used for Leishmania spp. detection in dogs and...
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Investigation of Atherosclerotic Plaque Vulnerability
Histochemical and immunohistochemical approaches permit the detection and evaluation of proteins and cell types within murine brachiocephalic artery...
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PRL-mediated STAT5B/ARRB2 pathway promotes the progression of prostate cancer through the activation of MAPK signaling
Previous study showed that higher expression of prolactin (PRL) was found in CRPC samples compared with hormone-naive prostate cancer (HNPC) and...
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Detection and Functional Analysis of Estrogen Receptor α Phosphorylated at Serine 216 in Mouse Neutrophils
Serine 216 constitutes a protein kinase C phosphorylation motif located within the DNA binding domain of estrogen receptor α (ERα). In this chapter,...
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Glycoform-Specific Visualization in Immunohistochemistry by “Lectin Inhibition”
Antibodies are useful for localizing glycoprotein antigens in histochemistry, but they do not differentiate glycoforms in tissue sections because...
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Detection of Equus caballus papillomavirus-2 in equine penile/preputial papillomas and squamous cell carcinomas in southern Brazil
For approximately one decade, a novel papillomavirus termed Equus caballus papillomavirus-2 (EcPV-2) has been associated with equine penile/preputial...
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A reliable mouse model of liver and lung metastasis by injecting esophageal cancer stem cells (CSCs) through tail-vein injection
BackgroundEsophageal Squamous Cell Carcinoma (ESCC) is a highly aggressive tumor with increased metastatic potential. Recent evidence suggests that...
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3D Imaging for Cleared Tissues and Thicker Samples on Confocal and Light-Sheet Microscopes
Advances in fluorescence microscopy, specifically the development of confocal and light-sheet microscopes, have enabled researchers to harness tissue...
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Chondrogenic Differentiation of Human-Induced Pluripotent Stem Cells
The generation of large quantities of genetically defined human chondrocytes remains a critical step for the development of tissue engineering...
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TRIM5 as a promising diagnostic biomarker of hepatocellular carcinoma: integrated analysis and experimental validation
The TRIM family is associated with the membrane, and its involvement in the progression, growth, and development of various cancer types has been...
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ANGPTL3 is involved in kidney injury in high-fat diet-fed mice by suppressing ACTN4 expression
ObjectiveWe wanted to explore how angiopoietin-like 3 (ANGPTL3) impact hyperlipidemia-induced renal injury.
MethodsANGPTL3 knockout mice and...
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PSMA1 mediates tumor progression and poor prognosis of gastric carcinoma by deubiquitinating and stabilizing TAZ
The deubiquitinating enzyme family in tumor progression play important role in intracellular protein degradation. The proteasome subunit alpha type 1...
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Intrathecal injection of human placental mesenchymal stem cells derived exosomes significantly improves functional recovery in spinal cord injured rats
BackgroundSpinal cord injury (SCI) due to lack of restoration of damaged neuronal cells is associated with sensorimotor impairment. This study was...
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Quantitative proteomic analysis of HER2 protein expression in PDAC tumors
Metastatic pancreatic adenocarcinoma (PDAC) is the third leading cause of cancer-related death in the United States, with a 5-year survival rate of...
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POLE2 knockdown suppresses lymphoma progression via downregulating Wnt/β-catenin signaling pathway
Lymphoma is the most common malignant tumor arising from immune system. Recently, DNA polymerase epsilon subunit 2 (POLE2) was identified to be a...
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USP40 promotes hepatocellular carcinoma cell proliferation, migration and stemness by deubiquitinating and stabilizing Claudin1
BackgroundHepatocellular carcinoma (HCC) is a prevalent malignant tumor that poses a major threat to people’s lives and health. Previous studies have...
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HOOK3 suppresses proliferation and metastasis in gastric cancer via the SP1/VEGFA axis
HOOK3, a member of the human hook microtubule-tethering protein family, has been implicated in the progression of cancer. However, the role of HOOK3...
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HAHNet: a convolutional neural network for HER2 status classification of breast cancer
ObjectiveBreast cancer is a significant health issue for women, and human epidermal growth factor receptor-2 (HER2) plays a crucial role as a vital...
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Nanoparticle (NP)-mediated APOC1 silencing to inhibit MAPK/ERK and NF-κB pathway and suppress breast cancer growth and metastasis
Breast cancer is one of the most common malignant tumors with high mortality and poor prognosis in women. There is an urgent need to discover new...
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Lamina-specific immunohistochemical signatures in the olfactory bulb of healthy, Alzheimer’s and Parkinson’s disease patients
Traditional neuroanatomy immunohistology studies involve low-content analyses of a few antibodies of interest, typically applied and compared across...
