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The Response of the Cell Genome of Endometrial Mesenchymal Stem Cells to the Procedure of Long-Term Cyropreservation
AbstractInformation about the effect of cryopreservation on cellular functions and the genetic apparatus of cells of differing genesis is not...
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Modifying effects of nerolidol on cell surface glycoconjugates and suppressed inflammation during DMBA-induced oral carcinogenesis: An in vivo and in silico
Oral squamous cell carcinomas (OSCC) were created in the buccal pouches of golden Syrian hamsters by painting them three times a week with 0.5% DMBA...
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A trifunctional peptide broadly inhibits SARS-CoV-2 Delta and Omicron variants in hamsters
The emergence of highly transmissible SARS-CoV-2 variants has led to the waves of the resurgence of COVID-19 cases. Effective antivirals against...
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Production of functional oocytes requires maternally expressed PIWI genes and piRNAs in golden hamsters
Many animals have a conserved adaptive genome defence system known as the Piwi-interacting RNA (piRNA) pathway, which is essential for germ cell...
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Inhibition of oxidative stress induced-cytotoxicity by coptisine in V79-4 Chinese hamster lung fibroblasts through the induction of Nrf-2 mediated HO-1 expression
BackgroundCoptisine is a natural alkaloid compound and is known to have multiple beneficial effects including antioxidant activity. However, whether...
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Journeying
Instinctively, his first task was to try and do something with the corpses, over fourteen bodies, including the few pets, like Max, a hamster named...
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Expression analysis suggests that DNMT3L is required for oocyte de novo DNA methylation only in Muridae and Cricetidae rodents
BackgroundDuring early mammalian development, DNA methylation undergoes two waves of reprogramming, enabling transitions between somatic cells,...
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Monitoring the Secretion and Activity of Alpha-1 Antitrypsin in Various Mammalian Cell Types
Overexpression of recombinant protein in mammalian cells is widely used for producing biologics, as protein maturation and post-translational...
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Distance effect characteristic of the matrix attachment region increases recombinant protein expression in Chinese hamster ovary cells
ObjectivesPreviously, we have found that the matrix attachment region (MAR) may confer a ‘distance effect’ on transgene expression. This work aims to...
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RNA G-quadruplex formed in SARS-CoV-2 used for COVID-19 treatment in animal models
The ongoing COVID-19 pandemic has continued to affect millions of lives worldwide, leading to the urgent need for novel therapeutic strategies....
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Standardization of chronic uterine infection of hamsters by Leptospira santarosai serovar Guaricura, from serogroup Sejroe
Leptospirosis is an important zoonosis that in cattle is characterized as a reproductive disease. It is well reported that the main agent of bovine...
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Cytotoxicity and genotoxicity of silver nanoparticles in Chinese Hamster ovary cell line (CHO-K1) cells
Biomedical and pharmaceutical products comprising silver nanoparticles are attracting interest due to their potent antibacterial activities. For...
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COVID-19 instigates adipose browning and atrophy through VEGF in small mammals
Patients with COVID-19 frequently manifest adipose atrophy, weight loss and cachexia, which significantly contribute to poor quality of life and...
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Genotoxicity evaluation of collagen peptide derived from skate (Raja kenojei) skin: In vitro and in vivo studies
BackgroundThe medicinal properties and benefits of collagen peptides (CPs) are widely recognized and utilized. However, the potential genotoxicity of...
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Speciation in a MacArthur model predicts growth, stability, and adaptation in ecosystem dynamics
Ecosystem dynamics is often considered driven by a coupling of species’ resource consumption and its population size dynamics. Such...
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Small Mammal Communities in the Middle Ob Valley
AbstractSmall mammal communities in different sections of the Middle Ob valley (floodplain and terrace) are considered based on an analysis of our...
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Two waves of evolution in the rodent pregnancy-specific glycoprotein (Psg) gene family lead to structurally diverse PSGs
BackgroundThe evolution of pregnancy-specific glycoprotein (PSG) genes within the CEA gene family of primates correlates with the evolution of...
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Effects and mechanism of small molecule additives on recombinant protein in CHO cells
AbstractChinese hamster ovary (CHO) cells can produce proteins with complex structures and post-translational modifications which are similar to...
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Enabling Hamster Embryo Culture System: Development of Preimplantation Embryos
Development of preimplantation embryos, from fertilization to hatched-blastocyst stage, has been a challenging task, regardless of the mammalian...
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Similar adaptative mechanism but divergent demographic history of four sympatric desert rodents in Eurasian inland
Phenotypes associated with metabolism and water retention are thought to be key to the adaptation of desert species. However, knowledge on the...
