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Genetic continuity, isolation, and gene flow in Stone Age Central and Eastern Europe
The genomic landscape of Stone Age Europe was shaped by multiple migratory waves and population replacements, but different regions do not all show...
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Specific dopaminergic genetic variants influence impulsivity, cognitive deficit, and disease severity of Indian ADHD probands
BackgroundImpulsivity (Imp), being one of the cardinal symptoms of Attention Deficit Hyperactivity Disorder (ADHD), often leads to inappropriate...
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N-Acetyltransferase 9 ameliorates Aβ42-mediated neurodegeneration in the Drosophila eye
Alzheimer’s disease (AD), a progressive neurodegenerative disorder, manifests as accumulation of amyloid-beta-42 (Aβ42) plaques and intracellular...
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Genetic connectivity in Sparisoma aurofrenatum (redband parrotfish): an unexpected journey
Oceanic biogeographic barriers disrupt population connectivity and are produced by currents, changes in sea surface temperature, geomorphology,...
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A SNARE protective pool antagonizes APOL1 renal toxicity in Drosophila nephrocytes
BackgroundPeople of Sub-Saharan African ancestry are at higher risk of develo** chronic kidney disease (CKD), attributed to the Apolipoprotein L1 (
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Genetic dysregulation of immunologic and oncogenic signaling pathways associated with tumor-intrinsic immune resistance: a molecular basis for combination targeted therapy-immunotherapy for cancer
Since the turn of the century, advances in targeted therapy and immunotherapy have revolutionized the treatment of cancer. Although these approaches...
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hkb is required for DIP-α expression and target recognition in the Drosophila neuromuscular circuit
Our nervous system contains billions of neurons that form precise connections with each other through interactions between cell surface proteins. In Drosophila...
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Profiling the genetic determinants of chromatin accessibility with scalable single-cell CRISPR screens
CRISPR screens have been used to connect genetic perturbations with changes in gene expression and phenotypes. Here we describe a CRISPR-based,...
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Genetic variation at the catalytic subunit of glutamate cysteine ligase contributes to the susceptibility to sporadic colorectal cancer: a pilot study
BackgroundGlutathione is a tripeptide detoxifying a variety of exogenous and endogenous free radicals and carcinogens, and a deficiency of...
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Genetic map** of microbial and host traits reveals production of immunomodulatory lipids by Akkermansia muciniphila in the murine gut
The molecular bases of how host genetic variation impacts the gut microbiome remain largely unknown. Here we used a genetically diverse mouse...
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Genetic and transcriptomic dissection of an artificially induced paired spikelets mutant of wheat (Triticum aestivum L.)
Key messageMorphological, genetic and transcriptomic characterizations of an EMS-induced wheat paired spikelets (PS) mutant were performed. A novel...
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Genetic variation and differentiation of Quercus variabilis populations at phosphate and non-phosphate rock sites in southwestern China
Subtropical soils are generally characterized by phosphorus (P), calcium (Ca) and magnesium (Mg) deficiency; extreme P-rich soils develop on...
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RNP-Based Control Systems for Genetic Circuits in Synthetic Biology Beyond CRISPR
Ribonucleoproteins (RNPs) are RNA-protein complexes utilized natively in both prokaryotes and eukaryotes to regulate essential processes within the...
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Genetic modifiers and phenotypic variability in neuromuscular disorders
Neuromuscular disorders are mostly rare diseases with autosomal dominant, recessive, or X-linked inheritance. Interestingly, among patients carrying...
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Genetic characterization and fine map** of qHMS4 responsible for pollen sterility in hybrids between Oryza sativa L. and Oryza glaberrima Steud
African cultivated rice ( Oryza glaberrima Steud) contains many favorable genes for tolerance to biotic and abiotic stresses and F 1 hybrids between...
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High nuclear expression of DNMT1 in correlation with inactivation of TET1 portray worst prognosis among the cervical carcinoma patients: clinical implications
In this study, we aimed to understand the interplay of the epigenetic modifier genes DNMT1 and TET1 along with HPV infection in the cervical...
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A Genetic Interaction Screening Approach in C. elegans
Genetic interaction screens have played a critical role in better understanding epistasis and functional relationships among genes. These screens...
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Transcriptome architecture reveals genetic networks of bolting regulation in spinach
BackgroundBolting refers to the early flowering stem production on agricultural and horticultural crops before harvesting. Indeed, bolting is an...
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Clinical report and genetic analysis of a novel variant in ZMIZ1 causing neurodevelopmental disorder with dysmorphic factors and distal skeletal anomalies in a Chinese family
BackgroundNeurodevelopmental disorder with dysmorphic factors and distal skeletal anomalies (NEDDFSA) is a rare and phenotypically variable disorder....
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miR-277 targets the proapoptotic gene-hid to ameliorate Aβ42-mediated neurodegeneration in Alzheimer’s model
Alzheimer’s disease (AD), an age-related progressive neurodegenerative disorder, exhibits reduced cognitive function with no cure to date. One of the...
