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Quantifying ABCA1/apoA-1 Signaling Pathways with AFM Imaging and Lipidomic Analysis
The role of lipid metabolic pathways in the pathophysiology of primary open-angle glaucoma (POAG) has been thoroughly elucidated, with pathways...
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Extracellular Vesicles: The Challenges on the Way and Engineering Perspectives
Extracellular vesicles (EVs) are found in every body fluid and are known to be released by every human cell. So far, EVs have been classified into...
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mTORC1 regulates a lysosome-dependent adaptive shift in intracellular lipid species
The mechanistic target of rapamycin complex 1 (mTORC1) senses and relays environmental signals from growth factors and nutrients to metabolic...
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Distinct functions of wild-type and R273H mutant Δ133p53α differentially regulate glioblastoma aggressiveness and therapy-induced senescence
Despite being mutated in 92% of TP53 mutant cancers, how mutations on p53 isoforms affect their activities remain largely unknown. Therefore,...
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High-grade serous ovarian carcinoma, the “Achiles’ hill” for clinicians and molecular biologists: a molecular insight
High-grade serous ovarian carcinoma (HGSOC), the deadliest ovarian cancer, alone accounts for 90% of all its subtypes. Characterized by hallmark...
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Examining Mechanisms for Voltage-Sensitive Calcium Channel-Mediated Secretion Events in Bone Cells
In addition to their well-described functions in cell excitability, voltage-sensitive calcium channels (VSCCs) serve a critical role in calcium (Ca 2+ )...
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The Physical Factors Involved in Cancer Progression
Mechanical forces, generated externally and internally, regulate cancer development. Cancer continues to be a disease that is difficult to be healed...
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Phosphoinositides in plant-pathogen interaction: trends and perspectives
Phosphoinositides are important regulatory membrane lipids, with a role in plant development and cellular function. Emerging evidence indicates that...
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Impact of enteric bacterial infections at and beyond the epithelial barrier
The mucosal lining of the gut has co-evolved with a diverse microbiota over millions of years, leading to the development of specialized mechanisms...
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Mitochondrial supplementation of Sus scrofa metaphase II oocytes alters DNA methylation and gene expression profiles of blastocysts
BackgroundMitochondrial DNA (mtDNA) copy number in oocytes correlates with oocyte quality and fertilisation outcome. The introduction of additional...
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Mechanical regulation of early vertebrate embryogenesis
Embryonic cells grow in environments that provide a plethora of physical cues, including mechanical forces that shape the development of the entire...
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Single-cell stable isotope probing in microbial ecology
Environmental and host-associated microbiomes are typically diverse assemblages of organisms performing myriad activities and engaging in a network...
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Angular difference in human coronary artery governs endothelial cell structure and function
Blood vessel branch points exhibiting oscillatory/turbulent flow and lower wall shear stress (WSS) are the primary sites of atherosclerosis...
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Nanoencapsulation for Controlled Release of Active Components
Nanotechnology has become one of the most intriguing areas of scientific research and development. This cutting-edge technology focuses on nanoscale...
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Stress Responses in Pathogenic Vibrios and Their Role in Host and Environmental Survival
Vibrio is a genus of bacteria commonly found in estuarine, marine, and freshwater environments. Vibrio species have evolved to occupy diverse niches...
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Potential Antioxidant Enzymes from Fungi and Their Clinical Significance
Fungi are a group of heterotrophic eukaryotes capable of producing an array of enzymes. Most of the fungal enzymes are being used successfully in...
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Neurobehavioral dysfunction in a mouse model of Down syndrome: upregulation of cystathionine β-synthase, H2S overproduction, altered protein persulfidation, synaptic dysfunction, endoplasmic reticulum stress, and autophagy
Down syndrome (DS) is a genetic condition where the person is born with an extra chromosome 21. DS is associated with accelerated aging; people with...
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Endocytic Uptake of Nutrients, Cell Wall Molecules and Fluidized Cell Wall Portions into Heterotrophic Plant Cells
After arrival at the surface of heterotrophic cells, nutrients are taken up by these cells via endocytosis to sustain metabolic processes. Recent...
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Prokaryotic microvesicles Ortholog of eukaryotic extracellular vesicles in biomedical fields
Every single cell can communicate with other cells in a paracrine manner via the production of nano-sized extracellular vesicles. This phenomenon is...
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The VE-cadherin/AmotL2 mechanosensory pathway suppresses aortic inflammation and the formation of abdominal aortic aneurysms
Endothelial cells respond to mechanical forces exerted by blood flow. Endothelial cell–cell junctions and the sites of endothelial adhesion to the...
