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Mammary epithelial cell phagocytosis downstream of TGF-β3 is characterized by adherens junction reorganization
After weaning, during mammary gland involution, milk-producing mammary epithelial cells undergo apoptosis. Effective clearance of these dying cells...
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De novo assembly of the Carcinus maenas transcriptome and characterization of innate immune system pathways
BackgroundThe European shore crab, Carcinus maenas , is used widely in biomonitoring, ecotoxicology and for studies into host-pathogen interactions....
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Differential gene expression and alternative splicing in insect immune specificity
BackgroundEcological studies routinely show genotype-genotype interactions between insects and their parasites. The mechanisms behind these...
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Functional transcriptome analysis of the postnatal brain of the Ts1Cje mouse model for Down syndrome reveals global disruption of interferon-related molecular networks
BackgroundThe Ts1Cje mouse model of Down syndrome (DS) has partial triplication of mouse chromosome 16 (MMU16), which is partially homologous to...
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A depauperate immune repertoire precedes evolution of sociality in bees
BackgroundSociality has many rewards, but can also be dangerous, as high population density and low genetic diversity, common in social insects, is...
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Drosophila anti-nematode and antibacterial immune regulators revealed by RNA-Seq
BackgroundDrosophila melanogaster activates a variety of immune responses against microbial infections. However, information on the Drosophila ...
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Scrutinizing the immune defence inventory of Camponotus floridanus applying total transcriptome sequencing
BackgroundDefence mechanisms of organisms are shaped by their lifestyle, environment and pathogen pressure. Carpenter ants are social insects which...
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AMPK interacts with DSCAM and plays an important role in Netrin-1 induced neurite outgrowth
Down syndrome cell adhesion molecule (DSCAM) acts as a netrin-1 receptor and mediates attractive response of axons to netrin-1 in neural development....
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MDAT- Aligning multiple domain arrangements
BackgroundProteins are composed of domains, protein segments that fold independently from the rest of the protein and have a specific function....
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Plasticity of nervous and immune systems in different species: The role of proteasomes
The nervous and immune systems have many common features in their organization and functioning among various animal species, from insects to mammals....
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Regeneration and Growth as Modes of Adult Development: The Platyhelminthes as a Case Study
Some species of Platyhelminthes have become model systems in which to study whole-body regeneration in adults. Before describing how this capacity is...
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Graph-distance distribution of the Boltzmann ensemble of RNA secondary structures
BackgroundLarge RNA molecules are often composed of multiple functional domains whose spatial arrangement strongly influences their function....
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Antiviral responses of arthropod vectors: an update on recent advances
Arthropod vectors, such as mosquitoes, ticks, biting midges and sand flies, transmit many viruses that can cause outbreaks of disease in humans and...
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Genome-wide association and systems genetic analyses of residual feed intake, daily feed consumption, backfat and weight gain in pigs
BackgroundFeed efficiency is one of the major components determining costs of animal production. Residual feed intake (RFI) is defined as the...
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Quantitative proteomic analysis of amniocytes reveals potentially dysregulated molecular networks in Down syndrome
BackgroundDown syndrome (DS), caused by an extra copy of chromosome 21, affects 1 in 750 live births and is characterized by cognitive impairment and...
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Kassiopeia: a database and web application for the analysis of mutually exclusive exomes of eukaryotes
BackgroundAlternative splicing is an important process in higher eukaryotes that allows obtaining several transcripts from one gene. A specific case...
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Genome-guided transcript assembly by integrative analysis of RNA sequence data
The identification of full length transcripts entirely from short-read RNA sequencing data (RNA-seq) remains a challenge in the annotation of...
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The evolution of Dscamgenes across the arthropods
BackgroundOne way of creating phenotypic diversity is through alternative splicing of precursor mRNAs. A gene that has evolved a hypervariable form...
