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Oxidative Stress, Endoplasmic Reticulum Stress and Apoptosis in the Pathology of Alzheimer’s Disease
Alzheimer’s disease (AD) accounts for a major statistic among the class of neurodegenerative diseases. A number of mechanisms have been identified in...
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Nutrients and polyphenols-rich Sorghum bicolor genotypes as complementary therapy for Alzheimer’s disease
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and most common cause of dementia among older people. The main pathological...
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An insight for the inhibition of anxiolytic and anti-convulsant effects in zebrafish using the curcumins via exploring molecular docking and molecular dynamics simulations
In the contemporary landscape, anxiety and seizures stand as major areas of concern, prompting researchers to explore potential drugs against them....
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System Biology Approach in Investigating Epithelial-Mesenchymal Transition (EMT)
Epithelial-mesenchymal transition (EMT) is a trans-differentiating and reversible process that leads to dramatic cell phenotypic changes, enabling...
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High-Throughput Analysis to Identify Activators of Notch Signaling
The Notch pathway regulates many cellular functions in a context-dependent manner. Depending on the cell type, either the activation or inhibition of...
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The advent of Alzheimer treatments will change the trajectory of human aging
Slowing neurodegenerative disorders of late life has lagged behind progress on other chronic diseases. But advances in two areas, biochemical...
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The product of the γ-secretase processing of ephrinB2 regulates VE-cadherin complexes and angiogenesis
Presenilin-1 (PS1) gene encodes the catalytic component of γ-secretase, which proteolytically processes several type I transmembrane proteins. We...
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Herbs for Autoimmune Diseases
The incidence of autoimmune diseases worldwide is on the rise, with extensive impact on lifestyle of individuals and spiralling healthcare costs....
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Endocytosis and Alzheimer’s disease
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and is the most common cause of dementia. The pathogenesis of AD still remains...
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Potential of hsa-miR200a-3p and hsa-miR502-3p as blood-based biomarker for Alzheimer’s disease
BackgroundAlzheimer’s disease (AD) is one of the most important known dementia which affects thousands of people every year. Many factors are...
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The lipid rafts in cancer stem cell: a target to eradicate cancer
Cancer stem cells (CSCs) are a subpopulation of cancer cells with stem cell properties that sustain cancers, which may be responsible for cancer...
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Serotonin Receptors as a Potential Target in the Treatment of Alzheimer’s Disease
AbstractAlzheimer’s disease (AD) is the most common cause of dementia worldwide that has an increasing impact on aging societies. Besides its...
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Macrophage PTEN controls STING-induced inflammation and necroptosis through NICD/NRF2 signaling in APAP-induced liver injury
BackgroundPhosphatase and tensin homolog deleted on chromosome 10 (PTEN) signaling has been known to play a critical role in maintaining cellular and...
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Cancer epigenetics: from laboratory studies and clinical trials to precision medicine
Epigenetic dysregulation is a common feature of a myriad of human diseases, particularly cancer. Defining the epigenetic defects associated with...
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Converged avenues: depression and Alzheimer’s disease– shared pathophysiology and novel therapeutics
Depression, a highly prevalent disorder affecting over 280 million people worldwide, is comorbid with many neurological disorders, particularly...
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Recent advances on drug development and emerging therapeutic agents for Alzheimer’s disease
Alzheimer’s disease (AD) is a neurodegenerative old age disease that is complex, multifactorial, unalterable, and progressive in nature. The...
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Molecular targets of histone deacetylase inhibitors in neurodegeneration and neuroprotection
BackgroundNeurodegenerative diseases show various phenotypes of molecular and cellular malfunction including mitochondrial dysfunction and...
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An Adequate Supply of Bis(ethylmaltolato)oxidovanadium(IV) Remarkably Reversed the Pathological Hallmarks of Alzheimer’s Disease in Triple-Transgenic Middle-Aged Mice
Alzheimer’s disease (AD) is a complex and progressive neurodegenerative disease with impaired synapse, imbalanced mineral metabolism, protein...
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Regulation of the Notch-ATM-abl axis by geranylgeranyl diphosphate synthase inhibition
Notch proteins drive oncogenesis of many cancers, most prominently T-cell acute lymphoblastic leukemia (T-ALL). Because geranylgeranylated Rab...
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Emodin derivatives as promising multi-aspect intervention agents for amyloid aggregation: molecular docking/dynamics simulation, bioactivities evaluation, and cytoprotection
Alzheimer's disease (AD) is a progressive neurodegenerative disease with complex pathogenesis. Despite the pathogenesis is unknown, the misfolding...
