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ALKBH5 promotes PD-L1-mediated immune escape through m6A modification of ZDHHC3 in glioma
N6-methylation of adenosine (m6A) is one of the most frequent chemical modifications in eukaryotic RNAs and plays a vital role in tumorigenesis and...
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Integration of single sample and population analysis for understanding immune evasion mechanisms of lung cancer
A deep understanding of the complex interaction mechanism between the various cellular components in tumor microenvironment (TME) of lung...
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Immune boosting functional components of natural foods and its health benefits
Naturally available foods contain nutrients like vitamins (A, C, E, and D), zinc, calcium, magnesium, folate iron, omega fatty acids, selenium, and...
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Identification of ORM1, vWF, SPARC, and PPBP as immune-related proteins involved in immune thrombocytopenia by quantitative LC-MS/MS
BackgroundImmune thrombocytopenia (ITP) is a common autoimmune disease characterized by loss of immune tolerance to platelet autoantigens leading to...
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Selenium Deficiency Causes Iron Death and Inflammatory Injury Through Oxidative Stress in the Mice Gastric Mucosa
Selenium (Se) is a trace element essential for the maintenance of normal physiological functions in living organisms. Oxidative stress is a state in...
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The implications of FASN in immune cell biology and related diseases
Fatty acid metabolism, particularly fatty acid synthesis, is a very important cellular physiological process in which nutrients are used for energy...
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Immune, Inflammatory and Oxidative Stress-Related Biomarkers
In the exploration of schizophrenia spectrum disorders (SSD) pathophysiology, the involvement of inflammatory processes, mitochondrial functions, and...
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Tumors cells with mismatch repair deficiency induce hyperactivation of pyroptosis resistant to cell membrane damage but are more sensitive to co-treatment of IFN-γ and TNF-α to PANoptosis
Hypermutated neoantigens in cancers with DNA mismatch repair deficiency (dMMR) are prerequisites for favorable clinical responses to...
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Selenium Deficiency Leads to Reduced Skeletal Muscle Cell Differentiation by Oxidative Stress in Mice
Selenium (Se) is one of the essential trace elements in animal organisms with good antioxidant and immune-enhancing abilities. In this study, we...
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Serum Copper and Zinc Levels in Primary Immune Thrombocytopenia
Although the pathogenesis of immune thrombocytopenia is not fully known, oxidative stress is one of the etiological causes. Copper and zinc are...
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Diseases of the Immune System
This review presents, in detail and from multiple angles, the classification of diseases of the immune system during different periods of a person’s...
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Lysosomal sialidase NEU1, its intracellular properties, deficiency, and use as a therapeutic agent
Neuraminidase 1 (NEU1) is a lysosomal sialidase that cleaves terminal α-linked sialic acid residues from sialylglycans. NEU1 is biosynthesized in the...
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AMPK–a key factor in crosstalk between tumor cell energy metabolism and immune microenvironment?
Immunotherapy has now garnered significant attention as an essential component in cancer therapy during this new era. However, due to immune...
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Vitamin A deficiency impairs neutrophil-mediated control of Salmonella via SLC11A1 in mice
In sub-Saharan Africa, multidrug-resistant non-typhoidal Salmonella serovars are a common cause of fatal bloodstream infection. Malnutrition is a...
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Study of Changes in Glutathione Level in People with Iron Deficiency Anemia in Mosul City
AbstractThe study was based to find out the effect of iron deficiency anemia on glutathione concentration, and the level of peroxynitrite was taken...
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Integrated analysis reveals FLI1 regulates the tumor immune microenvironment via its cell-type-specific expression and transcriptional regulation of distinct target genes of immune cells in breast cancer
BackgroundImmunotherapy is a practical therapeutic approach in breast cancer (BRCA), and the role of FLI1 in immune regulation has gradually been...
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Identification of genotype–biochemical phenotype correlations associated with fructose 1,6-bisphosphatase deficiency
Fructose-1,6-bisphosphatase (FBPase) deficiency, caused by an FBP1 mutation, is an autosomal recessive disorder characterized by hypoglycemic lactic...
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Marginal Maternal Zinc Deficiency Produces Liver Damage and Altered Zinc Transporter Expression in Offspring Male Rats
The aim of this study was to investigate how zinc deficiency and supplementation affect liver markers including autotaxin, kallistatin, endocan, and...
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Transcriptomics to Dissect the Immune System
The immune system functions to protect the host from diverse pathogenic microorganisms as well as cancers, where transcriptional regulations in...
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ClpP/ClpX deficiency impairs mitochondrial functions and mTORC1 signaling during spermatogenesis
Caseinolytic protease proteolytic subunit (ClpP) and caseinolytic protease X (ClpX) are mitochondrial matrix peptidases that activate mitochondrial...
