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Cardiac progenitor cell therapy: mechanisms of action
Heart failure (HF) is an end-stage of many cardiac diseases and one of the main causes of death worldwide. The current management of this disease...
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Severe cardiac and skeletal manifestations in DMD-edited microminipigs: an advanced surrogate for Duchenne muscular dystrophy
Duchenne muscular dystrophy (DMD) is an intractable X-linked muscular dystrophy caused by mutations in the DMD gene. While many animal models have...
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Stem Cell Applications in Cardiac Tissue Regeneration
Cardiovascular pathologies are the leading cause of morbidity and mortality worldwide. While heart transplant remains the gold standard, it is...
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MRI Quantification of Cardiac Structure and Function in Cardiomyopathy Patients
Cardiac Magnetic Resonance Imaging (CMRI) is a quantitative technique that enables non-invasive assessment of heart structure and contractile...
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It takes two to tango: cardiac fibroblast-derived NO-induced cGMP enters cardiac myocytes and increases cAMP by inhibiting PDE3
The occurrence of NO/cGMP signalling in cardiac cells is a matter of debate. Recent measurements with a FRET-based cGMP indicator in isolated cardiac...
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Cardiac cell senescence: molecular mechanisms, key proteins and therapeutic targets
Cardiac aging, particularly cardiac cell senescence, is a natural process that occurs as we age. Heart function gradually declines in old age,...
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Antigen presentation by cardiac fibroblasts promotes cardiac dysfunction
Heart failure (HF) is a leading cause of morbidity and mortality. Studies in animal models and individuals with HF revealed a prominent role for CD4 + ...
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Recent advances and future prospects in direct cardiac reprogramming
Cardiovascular disease remains a leading cause of death worldwide despite important advances in modern medical and surgical therapies. As human adult...
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Animal Models for Cardiac Valve Research
The modern era of cardiac valve repair and replacement has its foundations rooted in the pioneering research completed by surgeons, scientists, and...
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Harnessing stem cell and lineage reprogramming technology to treat cardiac fibrosis
Cardiac fibrosis is a pathological response characterized by excessive deposition of fibrous connective tissue within the heart. It typically occurs...
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Expression of expanded GGC repeats within NOTCH2NLC causes cardiac dysfunction in mouse models
BackgroundNeuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disorder characterized by widespread intranuclear inclusions in...
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Genetic lineage tracing identifies cardiac mesenchymal-to-adipose transition in an arrhythmogenic cardiomyopathy model
Arrhythmogenic cardiomyopathy (ACM) is one of the most common inherited cardiomyopathies, characterized by progressive fibrofatty replacement in the...
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Mechanism of post-tetanic depression of slow muscle fibres
A brief tetanic stimulation has a very different effect on the subsequent isometric twitch force of fast and slow skeletal muscles. Fast muscle...
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Skeletal Muscle Formation, Regeneration, and Recovery from Injury
In this chapter, we embark on a journey through the remarkable world of skeletal muscle formation, regeneration, and recovery from injury. Skeletal...
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Space microgravity increases expression of genes associated with proliferation and differentiation in human cardiac spheres
Efficient generation of cardiomyocytes from human-induced pluripotent stem cells (hiPSCs) is important for their application in basic and...
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Tropomyosin 3 (TPM3) function in skeletal muscle and in myopathy
The tropomyosin genes ( TPM1-4 ) contribute to the functional diversity of skeletal muscle fibers. Since its discovery in 1988, the TPM3 gene has been...
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Measurement of Fatty Acid Oxidation by High-Resolution Respirometry: Special Considerations for Analysis of Skeletal and Cardiac Muscle and Adipose Tissue
High-resolution respirometry is a state-of-the-art approach for the quantitation of mitochondrial function. Isolated mitochondria, cultured cells, or...
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Egr1 regulates regenerative senescence and cardiac repair
Senescence plays a key role in various physiological and pathological processes. We reported that injury-induced transient senescence correlates with...
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An updated C. elegans nuclear body muscle transcriptome for studies in muscle formation and function
The body muscle is an important tissue used in organisms for proper viability and locomotion. Although this tissue is generally well studied and...
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Engineered platforms for mimicking cardiac development and drug screening
Congenital heart defects are associated with significant health challenges, demanding a deep understanding of the underlying biological mechanisms...
