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Idiopathic pulmonary fibrosis (IPF): disease pathophysiology, targets, and potential therapeutic interventions
Idiopathic pulmonary fibrosis (IPF) is a progressive, degenerative pulmonary condition. Transforming growth factor (TGF)-β, platelet-derived growth...
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Circular dorsal ruffles disturb the growth factor-induced PI3K-AKT pathway in hepatocellular carcinoma Hep3B cells
BackgroundCircular dorsal ruffles (CDRs) are rounded membrane ruffles induced on the dorsal surfaces of cells stimulated by growth factors (GF). They...
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The effect of bta-miR-1296 on the proliferation and extracellular matrix synthesis of bovine mammary fibroblasts
Mammary fibrosis in dairy cows is a chronic condition caused by mastitis, and can lead to serious culling of dairy cows resulting in huge economic...
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Platelet extracellular vesicles enhance the proangiogenic potential of adipose-derived stem cells in vivo and in vitro
BackgroundAdipose-derived mesenchymal stem cells (ADSC)-based therapy is an outstanding treatment strategy for ischaemic disease. However, the...
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The Cytokine Profile of Myocardial Cells with Coronary Heart Disease and Ischemic Cardiomyopathy
AbstractIn this work, a comparative analysis of the myocardial cytokine profile was carried out in patients with coronary heart disease (CHD) and in...
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Tmsb10 triggers fetal Leydig differentiation by suppressing the RAS/ERK pathway
Leydig cells in fetal testes play crucial roles in masculinizing fetuses through androgen production. Gene knockout studies have revealed that growth...
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The effects and potential applications of concentrated growth factor in dentin–pulp complex regeneration
The dentin–pulp complex is essential for the long-term integrity and viability of teeth but it is susceptible to damage caused by external factors....
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Growth factor therapy for cardiac repair: an overview of recent advances and future directions
Heart disease represents a significant public health burden and is associated with considerable morbidity and mortality at the level of the...
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Osteoclast-derived extracellular vesicles are implicated in sensory neurons sprouting through the activation of epidermal growth factor signaling
BackgroundDifferent pathologies, affecting the skeletal system, were reported to display altered bone and/or cartilage innervation profiles leading...
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Down-regulation of PTTG1 suppresses PDGF-BB-induced proliferation, migration and extracellular matrix production of airway smooth muscle cells (ASMCs) by regulating PI3K/AKT/mTOR signaling pathway
BackgroundsTo investigate the biological functions and the molecular mechanisms of PTTG1 in PDGF-BB-induced ASMCs.
ObjectivesQPCR and western...
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Inhibition of PDGFRβ alleviates endothelial cell apoptotic injury caused by DRP-1 overexpression and mitochondria fusion failure after mitophagy
AbstractKawasaki disease (KD), described as “mucocutaneous lymph node syndrome” , affects infants and toddlers. Patients with KD suffer from an...
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A homogalacturonan from Lonicera japonica Thunb. disrupts angiogenesis via epidermal growth factor receptor and Delta-like 4 associated signaling
A homogeneous polysaccharide named as LJW2F2 was extracted and purified from the flowers of Lonicera japonica Thunb. Structural characteristic...
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TUG1 enhances high glucose-impaired endothelial progenitor cell function via miR-29c-3p/PDGF-BB/Wnt signaling
BackgroundDiabetes is associated with the dysfunction of endothelial progenitor cells (EPCs), characterized as impaired angiogenesis, a phenomenon...
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Culturing Conditions Dictate the Composition and Pathways Enrichment of Human and Rat Perirenal Adipose-Derived Stromal Cells’ Secretomes
Understanding the impact of various culturing strategies on the secretome composition of adipose-derived stromal cells (ASC) enhances their...
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Synergistic impact of platelet rich plasma-heparin sulfate with hydroxyapatite/zirconia on the osteoblast differentiation potential of adipose-derived mesenchymal stem cells
3D porous hydroxyapatite (HA) has been reinforced by zirconia (ZrO 2 ) coating and impregnation with a combination of platelet rich plasma (PRP) as a...
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Stem cell therapy combined with controlled release of growth factors for the treatment of sphincter dysfunction
Sphincter dysfunction often occurs at the end of tubule organs such as the urethra, anus, or gastroesophageal sphincters. It is the primary...
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Induced pluripotent stem cell derived pericytes respond to mediators of proliferation and contractility
BackgroundPericytes are multifunctional contractile cells that reside on capillaries. Pericytes are critical regulators of cerebral blood flow and...
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Intra‐articular Injection of PDGF-BB Explored in a Novel in Vitro Model Mobilizes Mesenchymal Stem Cells From the Synovium Into Synovial Fluid in Rats
BackgroundDrugs that can induce mesenchymal stem cell (MSC) mobilization from synovium into synovial fluid will enable regenerative medicine in...
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Culture Protocol and Transcriptomic Analysis of Murine SVZ NPCs and OPCs
The mammalian adult brain contains two neural stem and precursor (NPC) niches: the subventricular zone [SVZ] lining the lateral ventricles and the...
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Endothelial plasticity drives aberrant vascularization and impedes cardiac repair after myocardial infarction
Myocardial infarction (MI) is a leading cause of death worldwide, largely because efficient interventions to restore cardiac function after MI are...
