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Mechanistic role of perfusion culture on bone regeneration
Bone tissue engineering (BTE) aims to develop engineered bone tissue to substitute conventional bone grafts. To achieve this, culturing the cells on...
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Exploring metabolic effects of dipeptide feed media on CHO cell cultures by in silico model-guided flux analysis
AbstractThere is a growing interest in perfusion or continuous processes to achieve higher productivity of biopharmaceuticals in mammalian cell...
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3D Cell Culture: Techniques For and Beyond Organoid Applications
In the rapidly evolving landscape of cell biology and biomedical research, three-dimensional (3D) cell culture has contributed not only to the...
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Towards a Continuous Production of Human Mesenchymal Stromal Cells in a Chemically Defined Medium: Opportunities and Challenges for a Robust and Scalable Expansion Process
Human mesenchymal stromal cells (hMSCs) are one of the most prominent cell types used for cell therapy application. Thereby the current clinical...
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An overview of the mechanisms underlying hypoxia tolerance differences in aquatic animals and their inspirations for aquaculture
The decline in dissolved oxygen concentrations has been one of the most important changes occurring in the oceans, greatly impacting the survival,...
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Production of Complex Proteins in Plants: From Farming to Manufacturing
Recombinant biopharmaceutical proteins such as growth factors and antibodies are typically produced in microbial or mammalian cells. However,...
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The nonpathogenic strain of Fusarium oxysporum FO12 induces Fe deficiency responses in cucumber (Cucumis sativus L.) plants
Main conclusionFO12 strain enhances Fe deficiency responses in cucumber plants, probably through the production of ethylene and NO in the subapical...
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Encapsulated explant in novel low shear perfusion bioreactor improve cell isolation, expansion and colony forming unit
One of most important issue in the field of regenerative medicine is selection of appropriate cells, scaffolds and bioreactors. The present study...
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Effects of Fibroblast Growth Factor-2 and Other Microsupplements on the Productivity of IgG- and IgA-Producing Cell Lines
Several serum-free media have been developed and are successfully used at present for the cultivation of various recombinant eukaryotic cell lines....
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High sensitivity of hop plants (Humulus lupulus L.) to limited soil water availability: the role of stomata regulation and xylem vulnerability to embolism
Drought poses a serious threat to the productivity of hop, an important perennial crop. However, the precise physiological mechanisms that make it...
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Decellularization of Pig Lung to Yield Three-Dimensional Scaffold for Lung Tissue Engineering
Lately, the need for three-dimensional (3D) cell culture has been recognized in order to closely mimic the organization of native tissues. Thus, 3D...
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Production of deuterated biomass by cultivation of Lemna minor (duckweed) in D2O
Main conclusionCommon duckweed Lemna minor was cultivated in 50% D 2 O to produce biomass with 50–60% deuterium incorporation containing cellulose...
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Optimal Methods of Cell Seeding and Cultivation on a Poly(L-lactide) Biodegradable Scaffold
Abstract—In modern cardiovascular surgery, there remains a problem associated with a lack of venous material for bypass operations. Great interest...
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Bone marrow-independent adventitial macrophage progenitor cells contribute to angiogenesis
Pathological angiogenesis promotes tumor growth, metastasis, and atherosclerotic plaque rupture. Macrophages are key players in these processes....
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Unveiling the potential of specific growth rate control in fed-batch fermentation: bridging the gap between product quantity and quality
During the epoch of sustainable development, leveraging cellular systems for production of diverse chemicals via fermentation has garnered attention....
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Natural Scaffolds Used for Liver Regeneration: A Narrative Update
Annually chronic liver diseases cause two million death worldwide. Although liver transplantation (LT) is still considered the best therapeutic...
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Stem Cell Bioreactors: Design, Structure, and Operation of Stem Cell Bioreactors
A bioreactor is a manufactured device or system that helps to produce biologically active substances such as yeast, bacteria, or mammalian cells...
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Cellular and Molecular Issues of Hemo- and Biocompatibility of Diamond-Like Carbon Films. A Brief Critical Review
Abstract —A review of thin amorphous films consisting of carbon in the state sp 3 (diamond) and sp 2 (graphite) hybridization of atomic orbitals (and,...
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Peptide recovery from chicken feather keratin and their anti-biofilm properties against methicillin-resistant Staphylococcus aureus (MRSA)
Bacteria have the potential to adhere to abiotic surfaces, which has an undesirable effect in the food industry because they can survive for...
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Preclinical Research of Stem Cells: Challenges and Progress
In recent years, great breakthroughs have been made in basic research and clinical applications of stem cells in regenerative medicine and other...
