Search
Search Results
-
RUNDC1 inhibits autolysosome formation and survival of zebrafish via clas** ATG14-STX17-SNAP29 complex
Autophagy serves as a pro-survival mechanism for a cell or a whole organism to cope with nutrient stress. Our understanding of the molecular...
-
Cellular depletion of major cathepsin proteases reveals their concerted activities for lysosomal proteolysis
Proteins delivered by endocytosis or autophagy to lysosomes are degraded by exo- and endoproteases. In humans 15 lysosomal cathepsins (CTS) act as...
-
Methylmalonic acidemia triggers lysosomal-autophagy dysfunctions
BackgroundMethylmalonic acidemia (MMA) is a rare inborn error of propionate metabolism caused by deficiency of the mitochondrial methylmalonyl-CoA...
-
The E3 ubiquitin ligase ITCH negatively regulates intercellular communication via gap junctions by targeting connexin43 for lysosomal degradation
Intercellular communication via gap junctions has a fundamental role in regulating cell growth and tissue homeostasis, and its dysregulation may be...
-
Uncovering impaired mitochondrial and lysosomal function in adipose-derived stem cells from obese individuals with altered biological activity
BackgroundAdipose-derived stem cells (ADSCs) have been extensively used in preclinical and clinical trials for treating various diseases. However,...
-
Protocol and Software for Automated Detection of Lysosome Active “Runs” and “Flights” with Wavelet Transform Approach
Lysosomes are highly dynamic degradation/recycling organelles that harbor sophisticated molecular sensors and signal transduction machinery through...
-
Teratogenic Effects of Drugs on Primary Lymphocytes Assessed by Flow Cytometry
Peripheral blood lymphocytes as primary cells can be isolated from human, animal, fetus, and placenta. These cells are an excellent cellular model...
-
BID and the α-bisabolol-triggered cell death program: converging on mitochondria and lysosomes
α-Bisabolol (BSB) is a plant-derived sesquiterpene alcohol able to trigger regulated cell death in transformed cells, while deprived of the general...
-
Stay in touch with the endoplasmic reticulum
The endoplasmic reticulum (ER), which is composed of a continuous network of tubules and sheets, forms the most widely distributed membrane system in...
-
Complex Topology of Ubiquitin Chains Mediates Lysosomal Degradation of MrgC Proteins
BackgroundActivation of Mas-related G protein-coupled receptor C (MrgC) receptors relieves pain, but also leads to ubiquitination of MrgC receptors....
-
LYST deficiency impairs autophagic lysosome reformation in neurons and alters lysosome number and size
Chediak–Higashi syndrome (CHS) is a rare, autosomal recessive disorder caused by biallelic mutations in the lysosomal trafficking regulator ( LYST )...
-
Lysosomal sialidase NEU1, its intracellular properties, deficiency, and use as a therapeutic agent
Neuraminidase 1 (NEU1) is a lysosomal sialidase that cleaves terminal α-linked sialic acid residues from sialylglycans. NEU1 is biosynthesized in the...
-
The emerging mechanisms and functions of microautophagy
‘Autophagy’ refers to an evolutionarily conserved process through which cellular contents, such as damaged organelles and protein aggregates, are...
-
Mobilization of cholesterol induces the transition from quiescence to growth in Caenorhabditis elegans through steroid hormone and mTOR signaling
Recovery from the quiescent developmental stage called dauer is an essential process in C. elegans and provides an excellent model to understand how...
-
Organelles in Disease
This book sheds light on how dysregulated organelle functions contribute to the pathology and progression of human diseases. To offer a broad...
-
Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer’s disease mouse models
Microglia and complement can mediate neurodegeneration in Alzheimer’s disease (AD). By integrative multi-omics analysis, here we show that astrocytic...
-
Impairing hydrolase transport machinery prevents human melanoma metastasis
Metastases are the major cause of cancer-related death, yet, molecular weaknesses that could be exploited to prevent tumor cells spreading are poorly...
-
Exposure of the inner mitochondrial membrane triggers apoptotic mitophagy
During apoptosis mediated by the intrinsic pathway, BAX/BAK triggers mitochondrial permeabilization and the release of cytochrome- c , followed by a...
-
An Investigation of the Regulatory Relationship of the Keap1/Nrf2/ARE Signaling System and Transcriptional Regulators of Lysosomal Biogenesis
AbstractDespite the key role of the Keap1/Nrf2/ARE redox-sensitive signaling system in cell metabolism, almost nothing is known about its association...
-
Methods to Assess Autophagic Activity in Dictyostelium
Autophagy is an intracellular clearance and recycling pathway that delivers different types of cargos to lysosomes for degradation. In recent years,...