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Establishing a Zebrafish Model for Borrelia burgdorferi Infection Using Immersion and Microinjection Methods
Borrelia burgdorferi is the spirochetal bacterium that causes Lyme disease. Even though antimicrobial sensitivity of B. burgdorferi has been widely...
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Immunohistochemical, Flow Cytometric, and ELISA-Based Analyses of Intracellular, Membrane-Expressed, and Extracellular Hsp70 as Cancer Biomarkers
The major stress-inducible 70 kDa heat shock (stress) protein 70 (Hsp70) is frequently overexpressed in highly aggressive tumor cells and thus might...
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RETRACTED ARTICLE: RAD54L promotes progression of hepatocellular carcinoma via the homologous recombination repair pathway
Hepatocellular carcinoma (HCC) is a malignant tumor with high incidence worldwide. The underlying mechanisms remain poorly understood. The DNA...
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Regulator of G protein signaling 16 restrains apoptosis in colorectal cancer through disrupting TRAF6-TAB2-TAK1-JNK/p38 MAPK signaling
Colorectal cancer (CRC) remains a major global cause of cancer-related mortality, lacking effective biomarkers and therapeutic targets. Revealing the...
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TYMS Knockdown Suppresses Cells Proliferation, Promotes Ferroptosis via Inhibits PI3K/Akt/mTOR Signaling Pathway Activation in Triple Negative Breast Cancer
Triple-negative breast cancer (TNBC) is characterized by a grim prognosis and numerous challenges. The objective of our study was to examine the role...
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Ultrasonic microbubbles promote mesenchymal stem cell homing to the fibrotic liver via upregulation of CXCR4 expression
ObjectiveTo investigate the mechanism of ultrasound microbubbles (UTMB) promoting stem cells homing to fibrotic liver.
MethodsBone marrow derived...
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Single-Molecule Fluorescent In Situ Hybridization (smFISH) on Whole-Mount Planarians
Since the establishment of planarian species as laboratory models, investigation of molecular pathways has relied heavily on visualization of...
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PRM-based quantitative proteomics analysis of altered HSP abundance in villi and decidua of patients with early missed abortion
ObjectiveIn this study, we aimed to identify differentially expressed heat shock protein (HSP) profiles in the villi and decidua from patients with...
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Fallopian tube lesions as potential precursors of early ovarian cancer: a comprehensive proteomic analysis
Ovarian cancer is the leading cause of death from gynecologic cancer worldwide. High-grade serous carcinoma (HGSC) is the most common and deadliest...
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Evaluation of the gene encoding carnitine transporter (OCTN2/SLC22A5) expression in human breast cancer and its association with clinicopathological characteristics
BackgroundFatty acid oxidation (FAO) is a major energy-generating process in the mitochondria and supports proliferation, growth, and survival of...
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Leukemia Inhibitory Factor and Cellular Renewal in Various Types of Pulmonary Fibrosis in Plutonium Production Workers
AbstractThis study was aimed to identify types of morphological and functional interactions between the leukemia inhibiting factor and the complex of...
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Antibody Validation for Estrogen Receptor Beta
Antibodies can cross-react with proteins other than their intended targets, and antibody-based applications can, if not properly validated, lead to...
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Exploration of glycosyltransferases mutation status in cervical cancer reveals PARP14 as a potential prognostic marker
This study investigates the potential role of Glycosyltransferases (GTs) in the glycosylation process and their association with malignant tumors....
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Characterization of Axon Guidance Phenotypes in Wnt/PCP Mutant Mice
Our lab showed that the Wnt family proteins can function as axon guidance molecules and the planar cell polarity (PCP) pathway mediates the function...
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Targeting cancer-associated adipocyte-derived CXCL8 inhibits triple-negative breast cancer progression and enhances the efficacy of anti-PD-1 immunotherapy
Cancer-associated adipocytes (CAAs), one of the primary stromal components, exhibit intimate crosstalk and release multiple cell factors mediating...
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The immune checkpoint TIGIT/CD155 promotes the exhaustion of CD8 + T cells in TNBC through glucose metabolic reprogramming mediated by PI3K/AKT/mTOR signaling
ObjectiveThe CD155/TIGIT axis has attracted considerable interest as an emerging immune checkpoint with potential applications in cancer...
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NADPH oxidase 4-mediating oxidative stress contributes to endometriosis
NADPH oxidase 4 (NOX4) plays an important role in the regulation of oxidative stress, which is associated with endometriosis. This study aims to...
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Immunohistochemical investigation of epithelial, mesenchymal, neuroectodermal, immune and endocrine markers in sterlet (Acipenser ruthenus), shortnose sturgeon (Acipenser brevirostrum) and common carp (Cyprinus carpio)
Immunohistochemistry (IHC) is a laboratory method widely used to characterize tissue and cell origin, both in human and veterinary medicine. In fish,...
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Detection of Equus caballus papillomavirus-2 in equine penile/preputial papillomas and squamous cell carcinomas in southern Brazil
For approximately one decade, a novel papillomavirus termed Equus caballus papillomavirus-2 (EcPV-2) has been associated with equine penile/preputial...
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MATN2 overexpression suppresses tumor growth in ovarian cancer via PTEN/PI3K/AKT pathway
The incidence rate of develo** ovarian cancer decreases over the years; however, mortality ranks top among malignancies of women, mainly metastasis...
