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An inferred fitness consequence map of the rice genome
The extent to which sequence variation impacts plant fitness is poorly understood. High-resolution maps detailing the constraint acting on the...
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Simultaneous Measurement of DNA Methylation and Nucleosome Occupancy in Single Cells Using scNOMe-Seq
Single-cell Nucleosome Occupancy and Methylome sequencing (scNOMe-seq) is a multimodal assay that simultaneously measures endogenous DNA methylation...
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De novo assembly of transcriptomes and differential gene expression analysis using short-read data from emerging model organisms – a brief guide
Many questions in biology benefit greatly from the use of a variety of model systems. High-throughput sequencing methods have been a triumph in the...
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Innovations in Artificial Induction of Plant Genetic Diversity
Plant breeding aimed at crop improvement is dependent upon the genetic variability in the available genetic resources. This is essentially required...
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Analysis of Trihelix Genes and Their Expression in Potato in Response to Abiotic Stresses
Trihelix genes have important roles in light response, growth/developmental stages, and environmental stresses. The aims of this study were to...
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Conservation Genomics of Neotropical Carnivores
The chapter addresses the current state of the field of conservation genomics focused on neotropical carnivores (Mammalia, Carnivora), the history of...
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Whole genome resequencing of the Iranian native dogs and wolves to unravel variome during dog domestication
BackgroundAdvances in genome technology have simplified a new comprehension of the genetic and historical processes crucial to rapid phenotypic...
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Group B Streptococcus Cas9 variants provide insight into programmable gene repression and CRISPR-Cas transcriptional effects
Group B Streptococcus (GBS; S. agalactiae ) causes chorioamnionitis, neonatal sepsis, and can also cause disease in healthy or immunocompromised...
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Bone mineral density loci specific to the skull portray potential pleiotropic effects on craniosynostosis
Skull bone mineral density (SK-BMD) provides a suitable trait for the discovery of key genes in bone biology, particularly to intramembranous...
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Regulation and function of transposable elements in cancer genomes
Over half of human genomic DNA is composed of repetitive sequences generated throughout evolution by prolific mobile genetic parasites called...
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A pangenome analysis pipeline provides insights into functional gene identification in rice
BackgroundA pangenome aims to capture the complete genetic diversity within a species and reduce bias in genetic analysis inherent in using a single...
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Genome-wide characterization and development of simple sequence repeat markers for genetic studies in pomegranate (Punica granatum L.)
Key messageGenome-wide characterization and development of first set of polymorphic Class I SSRs markers in pomegranate ( Punica granatum L.) through...
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Multiscale analysis of pangenomes enables improved representation of genomic diversity for repetitive and clinically relevant genes
Advancements in sequencing technologies and assembly methods enable the regular production of high-quality genome assemblies characterizing complex...
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A Proposed Framework to Identify Dispensable and Essential Functions in Bifidobacteria: Case Study of Bifidobacterium breve UCC2003 as a Prototype of Its Genus
Functional genomics of bacteria commonly aims at establishing genotype-phenotype links in microorganisms of industrial, technological and biomedical...
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Parental genomes segregate into distinct blastomeres during multipolar zygotic divisions leading to mixoploid and chimeric blastocysts
BackgroundDuring normal zygotic division, two haploid parental genomes replicate, unite and segregate into two biparental diploid blastomeres.
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Whole genome sequencing for the investigation of canine mammary tumor inheritance - an initial assessment of high-risk breast cancer genes reveal BRCA2 and STK11 variants potentially associated with risk in purebred dogs
BackgroundAlthough, in general, cancer is considered a multifactorial disease, clustering of particular cancers in pedigrees suggests a genetic...
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Differential expression of the AP2/EREBP gene family in the contrasting genotypes of maize provides insights of abiotic stress tolerance
Drought, heat, and salinity are the three most critical abiotic stresses that cause significant losses in agricultural production worldwide. Drought...
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Molecular Markers and Their Application in Fisheries and Aquaculture
Overfishing, pollution and human activities are making it harder to manage the fisheries. Recent developments in molecular technology and genome...
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Whole-genome sequencing of glioblastoma reveals enrichment of non-coding constraint mutations in known and novel genes
BackgroundGlioblastoma (GBM) has one of the worst 5-year survival rates of all cancers. While genomic studies of the disease have been performed,...
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GoPeaks: histone modification peak calling for CUT&Tag
Genome-wide map** of histone modifications is critical to understanding transcriptional regulation. CUT&Tag is a new method for profiling histone...
