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Diversity of endogenous avian leukosis virus subgroup E (ALVE) insertions in indigenous chickens
BackgroundAvian leukosis virus subgroup E (ALVE) insertions are endogenous retroviruses (ERV) that are restricted to the domestic chicken and its...
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Infectious Risk and Protection
Xenotransplantation as an optional strategy can overcome the human transplantable organs and donor shortage and failure of functional organs. The...
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Endogenous retroviruses drive species-specific germline transcriptomes in mammals
Gene regulation in the germline ensures the production of high-quality gametes, long-term maintenance of the species and speciation. Male germline...
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Optogenetic Interrogation of ChR2-Expressing GABAergic Interneurons After Transplantation into the Mouse Brain
This paper describes research methods to investigate the development of synaptic connections between transplanted GABAergic interneurons and...
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The Role of Retroelements in the Evolution of Animal Genomes
AbstractRetroelements (retrotransposons and endogenous retroviruses) are a class of mobile genetic elements that is widely represented in various...
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Trap** a somatic endogenous retrovirus into a germline piRNA cluster immunizes the germline against further invasion
BackgroundFor species survival, the germline must faithfully transmit genetic information to the progeny. Transposable elements (TEs) constitute a...
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Captive ERVWE1 triggers impairment of 5-HT neuronal plasticity in the first-episode schizophrenia by post-transcriptional activation of HTR1B in ALKBH5-m6A dependent epigenetic mechanisms
BackgroundAbnormalities in the 5-HT system and synaptic plasticity are hallmark features of schizophrenia. Previous studies suggest that the human...
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Host-mediated RNA editing in viruses
Viruses rely on hosts for life and reproduction, cause a variety of symptoms from common cold to AIDS to COVID-19 and provoke public health threats...
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Advances on genetic and genomic studies of ALV resistance
Avian leukosis (AL) is a general term for a variety of neoplastic diseases in avian caused by avian leukosis virus (ALV). No vaccine or drug is...
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CRISPR–ChIP reveals selective regulation of H3K79me2 by Menin in MLL leukemia
Chromatin regulation involves the selective recruitment of chromatin factors to facilitate DNA repair, replication and transcription. Here we...
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Endogenous retroviral insertions drive non-canonical imprinting in extra-embryonic tissues
BackgroundGenomic imprinting is an epigenetic phenomenon that allows a subset of genes to be expressed mono-allelically based on the parent of origin...
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Pseudoty** retrovirus like particles vaccine candidates with Hepatitis C virus envelope protein E2 requires the cellular expression of CD81
Hepatitis C virus (HCV) infects 3% of world population being responsible for nearly half a million deaths annually urging the need for a prophylactic...
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Dual inhibitors of DNMT and HDAC induce viral mimicry to induce antitumour immunity in breast cancer
The existing conventional treatments for breast cancer, including immune checkpoint blockade, exhibit limited effects in some cancers, particularly...
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Syncytin-1 nonfusogenic activities modulate inflammation and contribute to preeclampsia pathogenesis
Maternal cellular and humoral immune responses to the allogeneic fetoplacental unit are a normal part of pregnancy adaptation. Overactive or...
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Somatic Cell Fusion in Host Defense and Adaptation
Evidence of fusion of somatic cells has been noted in health and in disease for more than a century. The most obvious but uncertain hallmark has been...
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Interfering with retrotransposition by two types of CRISPR effectors: Cas12a and Cas13a
CRISPRs are a promising tool being explored in combating exogenous retroviral pathogens and in disabling endogenous retroviruses for organ...
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The functions of SET domain bifurcated histone lysine methyltransferase 1 (SETDB1) in biological process and disease
Histone methyltransferase SETDB1 (SET domain bifurcated histone lysine methyltransferase 1, also known as ESET or KMT1E) is known to be involved in...
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Origin of Life and Glycan
The origin of life is dependent on biodiversity, which is the pathway of evolution. Organism evolution is intricately connected with glycan...
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Generating Transgenic Animal Models: Recent Technological Advancements
Since the generation of the first transgenic animal by Gordan and Ruddle, several methods and procedures have been developed for the manipulation of...
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Molecular Basis of Cell Reprogramming into iPSCs with Exogenous Transcription Factors
A striking discovery in recent decades concerning the transcription factor (TF)-dependent process was the production of induced pluripotent stem cell...