Search
Search Results
-
Partial inhibition of mitochondrial complex I ameliorates Alzheimer’s disease pathology and cognition in APP/PS1 female mice
Alzheimer’s Disease (AD) is a devastating neurodegenerative disorder without a cure. Here we show that mitochondrial respiratory chain complex I is...
-
Mkk4 and Mkk7 are important for retinal development and axonal injury-induced retinal ganglion cell death
The mitogen-activated protein kinase (MAPK) pathway has been shown to be involved in both neurodevelopment and neurodegeneration. c-Jun N-terminal...
-
Die Regulation der Genexpression
Die Regulation der Genexpression, oder kurz Genregulation, beschreibt das Zusammenspiel von genetischen Sequenzen und deren Transkriptionsprodukten...
-
Emerging roles of long non-coding RNAs in cancer
Cancer is a physiological condition that has both the endogenous and exogenous influences on its progression. It originates from unusual cell growth,...
-
Genomic insights into mite phylogeny, fitness, development, and reproduction
BackgroundPredatory mites (Acari: Phytoseiidae) are the most important beneficial arthropods used in augmentative biological pest control of...
-
Jumu is required for circulating hemocyte differentiation and phagocytosis in Drosophila
BackgroundThe regulatory mechanisms of hematopoiesis and cellular immunity show a high degree of similarity between insects and mammals, and Drosophila...
-
Down syndrome: from the age of characterization to the era of curative approach
Down syndrome (DS), the most prevalent autosomal disorder with a global incidence of 1 in 700 live births, was characterized in 1866 clinically and...
-
Transcriptome analysis of air-breathing land slug, Incilaria fruhstorferi reveals functional insights into growth, immunity, and reproduction
BackgroundIncilaria (= Meghimatium) fruhstorferi is an air-breathing land slug found in restricted habitats of Japan, Taiwan and selected provinces...
-
Mouse models of Down syndrome: gene content and consequences
Down syndrome (DS), trisomy of human chromosome 21 (Hsa21), is challenging to model in mice. Not only is it a contiguous gene syndrome spanning 35 Mb...
-
Mechanisms regulating dendritic arbor patterning
The nervous system is populated by diverse types of neurons, each of which has dendritic trees with strikingly different morphologies. These...
-
Protein-Coding and Noncoding RNA Genes
During the last decade, our understanding about human genes has gradually but drastically changed. When the human genome-sequencing project announced...
-
Regulation of neural circuit formation by protocadherins
The protocadherins (Pcdhs), which make up the most diverse group within the cadherin superfamily, were first discovered in the early 1990s. Data...
-
Mechanisms controlling diversification of olfactory sensory neuron classes
Animals survive in harsh and fluctuating environments using sensory neurons to detect and respond to changes in their surroundings. Olfactory sensory...
-
Role of pre-mRNA secondary structures in the regulation of alternative splicing
Alternative splicing of pre-mRNA is one of the main mechanisms regulating gene expression that generates multiple transcripts from one gene. The...
-
Mechanisms and in vivo functions of contact inhibition of locomotion
Contact inhibition of locomotion (CIL) is a process whereby a cell ceases motility or changes its trajectory upon collision with another cell. CIL...
-
Comparative transcriptomic analysis of immune responses of the migratory locust, Locusta migratoria, to challenge by the fungal insect pathogen, Metarhizium acridum
BackgroundThe migratory locust, Locusta migratoria manilensis, is an immensely destructive agricultural pest that forms a devastating and voracious...
-
Defense and Immune Systems
The complex of defensive strategies characterizing invertebrate immune systems and response is reviewed. These include the role of pathogen...
-
Improvement of Dscam homophilic binding affinity throughout Drosophilaevolution
BackgroundDrosophila Dscam1 is a cell-surface protein that plays important roles in neural development and axon tiling of neurons. It is known that...
-
Guidance receptors in the nervous and cardiovascular systems
Blood vessels and nervous fibers grow in parallel, for they express similar receptors for chemokine substances. Recently, much attention is being...
-
Global Approaches to Alternative Splicing and Its Regulation—Recent Advances and Open Questions
Pre-mRNA splicing is an essential RNA processing step in eukaryotes. Alternative splicing generates distinct spliced isoforms of the same gene,...