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Decoding the role of DNA methylation in allergic diseases: from pathogenesis to therapy
Allergic diseases, characterized by a broad spectrum of clinical manifestations and symptoms, encompass a significant category of IgE-mediated atopic...
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Herbs for Autoimmune Diseases
The incidence of autoimmune diseases worldwide is on the rise, with extensive impact on lifestyle of individuals and spiralling healthcare costs....
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Renal macrophages and NLRP3 inflammasomes in kidney diseases and therapeutics
Macrophages are exceptionally diversified cell types and perform unique features and functions when exposed to different stimuli within the specific...
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Clinical biomarkers for Lewy body diseases
Synucleinopathies are a group of neurodegenerative disorders characterized by pathologic aggregates of neural and glial α-synuclein (α-syn) in the...
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Ubiquitous protein lactylation in health and diseases
For decades, lactate has been considered a byproduct of glycolysis. The lactate shuttle hypothesis shifted the lactate paradigm, demonstrating that...
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Roles of the cytoskeleton in human diseases
Recently, researches have revealed the key roles of the cytoskeleton in the occurrence and development of multiple diseases, suggesting that...
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Systems Biology Approaches: Prevention, Diagnosis, and Understanding Mechanisms of Complex Diseases
This book examines the development and applications of system biology approaches for the prevention, diagnosis, and understanding of disease...
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Diseases of Carrot
Carrots (Dacus carota subsp. sativus (Hoffm.) Arcang.) are an important dietary source of vitamin A and a versatile vegetable consumed throughout the...
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Diseases of Fruits, Tubers, and Seeds Caused by Phoma sensu lato Species Complex
Fruits, tubers, and seeds contribute to human health, and their production generates high income for countries. The quality of these foods...
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Methylation in cornea and corneal diseases: a systematic review
Corneal diseases are among the primary causes of blindness and vision loss worldwide. However, the pathogenesis of corneal diseases remains elusive,...
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Pyroptosis in neurodegenerative diseases: from bench to bedside
The central nervous system regulates all aspects of physiology to some extent. Neurodegenerative diseases (NDDs) lead to the progressive loss and...
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Research Progress on the Role of Ubiquitination in Eye Diseases
The occurrence and development of ophthalmic diseases are related to the dysfunction of eye tissues. Ubiquitin is an important form of protein...
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A novel hybrid model to predict concomitant diseases for Hashimoto’s thyroiditis
Hashimoto’s thyroiditis is an autoimmune disorder characterized by the destruction of thyroid cells through immune-mediated mechanisms involving...
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Integrative Bioinformatics Approaches to Uncover Hub Genes and Pathways Involved in Cardiovascular Diseases
Cardiovascular diseases (CVD) represent a significant global health challenge resulting from a complex interplay of genetic, environmental, and...
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Roles of long noncoding RNAs in human inflammatory diseases
Chemokines, cytokines, and inflammatory cells mediate the onset and progression of many diseases through the induction of an inflammatory response....
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Diseases of Lima Bean
Lima beans (Phaseolus lunatus) are grown worldwide for food use, but the end-product may come in various forms. Lima beans are typically cultivated...
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Human 3D brain organoids: steering the demolecularization of brain and neurological diseases
Understanding of human brain development, dysfunction and neurological diseases has remained limited and challenging due to inability to recapitulate...
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Tree Diseases
Tree diseases are important agents of ecological disturbance in wooded ecosystems. Native tree diseases create forest gaps, thus diversifying forest...
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Mechanisms of PANoptosis and relevant small-molecule compounds for fighting diseases
Pyroptosis, apoptosis, and necroptosis are mainly programmed cell death (PCD) pathways for host defense and homeostasis. PANoptosis is a newly...
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Drug repurposing based on the DTD-GNN graph neural network: revealing the relationships among drugs, targets and diseases
MotivationThe rational modelling of the relationship among drugs, targets and diseases is crucial for drug retargeting. While significant progress...
