Search
Search Results
-
Induced pluripotent stem cells can improve thrombolytic effect of low-dose rt-PA after acute carotid thrombosis in rat
BackgroundIntravenous thrombolysis using recombinant tissue plasminogen activator (rt-PA) is the standard treatment for acute ischemic stroke....
-
Deciphering smooth muscle cell heterogeneity in atherosclerotic plaques and constructing model: a multi-omics approach with focus on KLF15/IGFBP4 axis
BackgroundRuptured atherosclerotic plaques often precipitate severe ischemic events, such as stroke and myocardial infarction. Unraveling the...
-
Single-cell T cell receptor sequencing of paired human atherosclerotic plaques and blood reveals autoimmune-like features of expanded effector T cells
Atherosclerosis is a lipid-driven chronic inflammatory disease; however, whether it can be classified as an autoimmune disease remains unclear. In...
-
Dog models of human atherosclerotic cardiovascular diseases
Cardiovascular diseases (CVD) are one of the leading causes of death worldwide. Eighty-five percent of CVD-associated deaths are due to heart attacks...
-
Trem2 promotes foamy macrophage lipid uptake and survival in atherosclerosis
Atherosclerosis is driven by the expansion of cholesterol-loaded ‘foamy’ macrophages in the arterial intima. Factors regulating foamy macrophage...
-
Targeting pro-inflammatory T cells as a novel therapeutic approach to potentially resolve atherosclerosis in humans
Atherosclerosis (AS), a leading cause of cardio-cerebrovascular disease worldwide, is driven by the accumulation of lipid contents and chronic...
-
Relationship between the non-HDLc-to-HDLc ratio and carotid plaques in a high stroke risk population: a cross-sectional study in China
BackgroundEvidence on the association between the non-high-density lipoprotein cholesterol (non-HDLc)-to-high-density lipoprotein cholesterol (HDLc)...
-
SARS-CoV-2 infection triggers pro-atherogenic inflammatory responses in human coronary vessels
Patients with coronavirus disease 2019 (COVID-19) present increased risk for ischemic cardiovascular complications up to 1 year after infection....
-
DNA Methylation Profiling in Aneurysm and Comorbid Atherosclerosis of the Ascending Aorta
AbstractAtherosclerosis and aneurysm of the aorta are relatively common pathological conditions that remain asymptomatic for a long period of time...
-
Oxysterols in Vascular Cells and Role in Atherosclerosis
Atherosclerosis is a major cardiovascular complication of diseases associated with elevated oxidative stress such as type 2 diabetes and metabolic...
-
Piezo1 mediates endothelial atherogenic inflammatory responses via regulation of YAP/TAZ activation
The vascular endothelium plays a key role in the pathobiology of atherosclerotic cardiovascular disease. Endothelial cell Piezo1 mediates blood...
-
Association of N6-methyladenine DNA with plaque progression in atherosclerosis via myocardial infarction-associated transcripts
Modification of the novel N 6 -methyladenine (m6A) DNA implicates this epigenetic mark in human malignant disease, but its role in atherosclerosis (AS)...
-
Macrophage polarization and metabolism in atherosclerosis
Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of fatty deposits in the inner walls of vessels. These plaques...
-
CD9 induces cellular senescence and aggravates atherosclerotic plaque formation
CD9, a 24 kDa tetraspanin membrane protein, is known to regulate cell adhesion and migration, cancer progression and metastasis, immune and allergic...
-
TREM2 protects from atherosclerosis by limiting necrotic core formation
Atherosclerosis is a chronic disease of the vascular wall driven by lipid accumulation and inflammation in the intimal layer of arteries, and its...
-
DNA methylation and histone post-translational modifications in atherosclerosis and a novel perspective for epigenetic therapy
Atherosclerosis, which is a vascular pathology characterized by inflammation and plaque build-up within arterial vessel walls, acts as the important...
-
Unravelling the role of cathepsins in cardiovascular diseases
Lysosomal cathepsins as a regulatory medium have been assessed as potential therapeutic targets for the treatment of various cardiac diseases such as...
-
Carotid plaques in adult rheumatoid arthritis patients; association with paroxonase 1 enzymatic activity and Q192R paroxonase 1 gene polymorphism
Paroxonase 1 (PON 1) enzymatic activity and Q192R PON polymorphism has been implicated with greater cardiovascular risk in general population....
-
Referral rate, profile and degree of control of patients with familial hypercholesterolemia: data from a single lipid unit from a Mediterranean area
BackgroundThe challenging rigorous management of hypercholesterolemia promotes referral to specialized units. This study explored the need, based on...
-
The age of bone marrow dictates the clonality of smooth muscle-derived cells in atherosclerotic plaques
Aging is the predominant risk factor for atherosclerosis—the leading cause of death. Rare smooth muscle cell (SMC) progenitors clonally expand,...
