Search
Search Results
-
A deep learning approach to detect and identify live freshwater macroinvertebrates
The study of macroinvertebrates using computer vision is in its infancy and still faces multiple challenges including destructive sampling, low...
-
High-throughput, targeted MHC class I immunopeptidomics using a functional genetics screening platform
Identification of CD8 + T cell epitopes is critical for the development of immunotherapeutics. Existing methods for major histocompatibility complex...
-
Research and prospects of bamboo bolts in China: state of the art
Bamboo has been used as a structural material for thousands of years. Due to its advantages in carbon absorption, mechanical properties, material...
-
Bifunctional peptides as alternatives to copper-based formulations to control citrus canker
AbstractCitrus canker is an infectious bacterial disease and one of the major threats to the orange juice industry, a multibillion-dollar market that...
-
Permanent deformation of triangle weaver silk enables ultrafast tangle-free release of spider webs
Entanglements are common in both natural and artificial systems and can result in both beneficial and harmful effects. Most spider webs are static...
-
Protein structure prediction with in-cell photo-crosslinking mass spectrometry and deep learning
While AlphaFold2 can predict accurate protein structures from the primary sequence, challenges remain for proteins that undergo conformational...
-
In-cell structural insight into the stability of sperm microtubule doublet
The propulsion for mammalian sperm swimming is generated by flagella beating. Microtubule doublets (DMTs) along with microtubule inner proteins...
-
Opening opportunities for Kd determination and screening of MHC peptide complexes
An essential element of adaptive immunity is selective binding of peptide antigens by major histocompatibility complex (MHC) class I proteins and...
-
How Structural Biology Has Directly Impacted Our Understanding of P2X Receptor Function and Gating
P2X receptors are ATP-gated ion channels expressed in a wide variety of eukaryotic cells. They play key roles in diverse processes such as platelet...
-
Click Chemistry for Liposome Surface Modification
Click chemistry, and particularly azide–alkyne cycloaddition, represents one of the principal bioconjugation strategies that can be used to...
-
AI-Based IoT Greenhouse Control System for Environmental Parameters
The environmental parameters of traditional greenhouse which need to be controlled continuously by farmers are not convenient and precise. In this...
-
Teichoic acids anchor distinct cell wall lamellae in an apically growing bacterium
The bacterial cell wall is a multicomponent structure that provides structural support and protection. In monoderm species, the cell wall is made up...
-
Comprehensive binary interaction map** of τ phosphotyrosine sites with SH2 domains in the human genome: Implications for the rational design of self-inhibitory phosphopeptides to target τ hyperphosphorylation signaling in Alzheimer’s Disease
Human microtubule-associated protein Tau (τ) is abundant in the axons of neurons where it stabilizes microtubule bundles; abnormally...
-
Increasing outer membrane complexity: the case of the lipopolysaccharide lipid A from marine Cellulophaga pacifica
Gram-negative bacteria living in marine waters have evolved peculiar adaptation strategies to deal with the numerous stress conditions that...
-
Structure of histone deacetylase complex Rpd3S bound to nucleosome
Crosstalk between histone modifications represents a fundamental epigenetic mechanism in gene regulation. During the transcription elongation...
-
Accurately estimating the length distributions of genomic micro-satellites by tumor purity deconvolution
BackgroundGenomic micro-satellites are the genomic regions that consist of short and repetitive DNA motifs. Estimating the length distribution and...
-
Insulin signalling regulates Pink1 mRNA localization via modulation of AMPK activity to support PINK1 function in neurons
Mitochondrial quality control failure is frequently observed in neurodegenerative diseases. The detection of damaged mitochondria by stabilization of...
-
Dynamic environments do not appear to constrain spider web building behaviour
Many laboratory experiments demonstrate how orb-web spiders change the architecture of their webs in response to prey, surroundings and wind loading....
-
Phylogeographic and quantitative trait locus analysis of the ability of Aegilops tauschii Coss., the D genome progenitor of common wheat, to cause genome doubling in the F1 hybrids with Triticum turgidum L., the AB genome progenitor
Aegilops tauschii Coss. (DD genome) is a wild paternal progenitor of common wheat ( Triticum aestivum L.; AABBDD genome). This species has genetically...
-
Structural basis of complex formation between mitochondrial anion channel VDAC1 and Hexokinase-II
Complex formation between hexokinase-II (HKII) and the mitochondrial VDAC1 is crucial to cell growth and survival. We hypothesize that HKII first...
