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Direct Drug Targeting into Intracellular Compartments: Issues, Limitations, and Future Outlook
Intracellular compartment drug delivery is a promising strategy for the treatment of diseases. By this way, medicines can delivered to particular...
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In silico prediction of the metabolism of Blastocrithidia nonstop, a trypanosomatid with non-canonical genetic code
BackgroundAlmost all extant organisms use the same, so-called canonical, genetic code with departures from it being very rare. Even more exceptional...
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A review of synthetic biology tools in Yarrowia lipolytica
Yarrowia lipolytica is a non-conventional oleaginous yeast with great potential for industrial production. Y. lipolytica has a high propensity for...
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Functional characterization of two homologs of yeast acetyl-coenzyme A synthetase in the entomopathogenic fungus Beauveria bassiana
Acetyl-coenzyme A (CoA) synthetase (Acs) links cellular metabolism and physiology by catalyzing acetate and CoA into acetyl-CoA. However, the...
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Predicting Peroxisomal Targeting Signals to Elucidate the Peroxisomal Proteome of Mammals
Peroxisomes harbor a plethora of proteins, but the peroxisomal proteome as the entirety of all peroxisomal proteins is still unknown for mammalian...
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A CRISPR–Cas12a system for multi-gene editing (CCMGE) and metabolic pathway assembly in Starmerella bombicola
The traditional homologous recombination (HR) gene-editing method faces problems such as low editing efficiency and absence of marker genes....
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Grundlagen der Biosynthese und des Abbaus von Proteinen
Auf dem Weg der Realisierung der genetischen Information wird nach erfolgter Transkription die in der mRNA enthaltene Information zur Bildung von...
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Recent advances in the microbial production of squalene
Squalene is a triterpene hydrocarbon, a biochemical precursor for all steroids in plants and animals. It is a principal component of human surface...
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Contribution of peroxisomal protein importer AflPex5 to development and pathogenesis in the fungus Aspergillus flavus
Peroxisomes are important organelles that have diverse metabolic functions and participate in the pathogenicity of fungal pathogens. Previous studies...
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A complete nicotinate degradation pathway in the microbial eukaryote Aspergillus nidulans
Several strikingly different aerobic and anaerobic pathways of nicotinate breakdown are extant in bacteria. Here, through reverse genetics and...
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The Obvious and the Hidden: Prediction and Function of Fungal Peroxisomal Matrix Proteins
Fungal peroxisomes are characterized by a number of specific biological functions. To understand the physiology and biochemistry of these organelles...
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Identification of Peroxisomal Protein Complexes with PTS Receptors, Pex5 and Pex7, in Mammalian Cells
Pex5 and Pex7 are cytosolic receptors for peroxisome targeting signal type-1 (PTS1) and type-2 (PTS2), respectively, and play a pivotal role in...
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Defining the Mammalian Peroxisomal Proteome
The current view on peroxisomes has changed dramatically from being human cell oddities to vital organelles that host several key metabolic pathways....
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Polyamine oxidase (PAO)–mediated polyamine catabolism plays potential roles in peach (Prunus persica L.) fruit development and ripening
Recently, there is an increased interest in the function of polyamine (PA) catabolism during fruit ripening, but little is known about its role...
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Unraveling of the Structure and Function of Peroxisomal Protein Import Machineries
Peroxisomes are dynamic organelles of eukaryotic cells performing a wide range of functions including fatty acid oxidation, peroxide detoxification...
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Phosphate Transporter OsPT4, Ubiquitinated by E3 Ligase OsAIRP2, Plays a Crucial Role in Phosphorus and Nitrogen Translocation and Consumption in Germinating Seed
Phosphorus (P) and nitrogen (N) are essential macronutrients necessary for plant growth and development. OsPT4 is a high-affinity phosphate (Pi)...
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Plant Peroxisomes and Their Metabolism of ROS, RNS, and RSS
Peroxisomes are subcellular organelles with a single membrane and devoid of DNA, with an essentially oxidative type of metabolism, and are probably...
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Transport systems, intracellular traffic of intermediates and secretion of β-lactam antibiotics in fungi
Fungal secondary metabolites are synthesized by complex biosynthetic pathways catalized by enzymes located in different subcellular compartments,...
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Highly flexible metabolism of the marine euglenozoan protist Diplonema papillatum
BackgroundThe phylum Euglenozoa is a group of flagellated protists comprising the diplonemids, euglenids, symbiontids, and kinetoplastids. The...
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Characterization of a class III peroxidase from Artemisia annua: relevance to artemisinin metabolism and beyond
Key messageA class III peroxidase from Artemisia annua has been shown to indicate the possibility of cellular localization-based role diversity,...
