Search
Search Results
-
MDM2 provides TOP2 poison resistance by promoting proteolysis of TOP2βcc in a p53-independent manner
DNA topoisomerase II (TOP2) is an enzyme that performs a critical function in manipulating DNA topology during replication, transcription, and...
-
Mutant p53 gain-of-function stimulates canonical Wnt signaling via PI3K/AKT pathway in colon cancer
Aberrant canonical Wnt signaling is a hallmark of colon cancer. The TP53 tumor suppressor gene is altered in many solid tumors, including colorectal...
-
Malic enzyme 2 maintains protein stability of mutant p53 through 2-hydroxyglutarate
Many types of cancer feature TP53 mutations with oncogenic properties. However, whether the oncogenic activity of mutant p53 is affected by the...
-
miR-221/222 induce instability of p53 By downregulating deubiquitinase YOD1 in acute myeloid leukemia
Acute myeloid leukemia (AML) is a hematological malignancy characterized by the impaired differentiation and uncontrolled proliferation of myeloid...
-
Tumor suppressor p53 mediates interleukin-6 expression to enable cancer cell evasion of genotoxic stress
The tumor suppressor p53 primarily functions as a mediator of DNA damage-induced cell death, thereby contributing to the efficacy of genotoxic...
-
LASS2 enhances p53 protein stability and nuclear import to suppress liver cancer progression through interaction with MDM2/MDMX
LASS2 functions as a tumor suppressor in hepatocellular carcinoma (HCC), the most common type of primary liver cancer, but the underlying mechanism...
-
USP22 regulates APL differentiation via PML-RARα stabilization and IFN repression
Ubiquitin-specific peptidase 22 (USP22) is a deubiquitinating enzyme (DUB) that underlies tumorigenicity, proliferation, cell death and...
-
BMAL1/p53 mediating bronchial epithelial cell autophagy contributes to PM2.5-aggravated asthma
BackgroundFine particulate matter (PM2.5) is associated with increased incidence and severity of asthma. PM2.5 exposure disrupts airway epithelial...
-
The p53 Tumor Suppressor and Copper Metabolism: An Unrevealed but Important Link
AbstractThe balance of redox reactions and the fate of the tumor cell are closely related to the regulation of intracellular homeostasis of...
-
KLF5 and p53 comprise an incoherent feed-forward loop directing cell-fate decisions following stress
In response to stress, cells make a critical decision to arrest or undergo apoptosis, mediated in large part by the tumor suppressor p53. Yet the...
-
p53 and HuR combinatorially control the biphasic dynamics of microRNA-125b in response to genotoxic stress
Post-transcriptional regulation of p53, by the microRNA miR-125b and the RNA-binding protein HuR, controls p53 expression under genotoxic stress. p53...
-
DNAJA1- and conformational mutant p53-dependent inhibition of cancer cell migration by a novel compound identified through a virtual screen
Cancers are frequently addicted to oncogenic missense mutant p53 (mutp53). DNAJA1, a member of heat shock protein 40 (HSP40), also known as J-domain...
-
Emerging role of tumor suppressor p53 in acute and chronic kidney diseases
p53 is a major regulator of cell cycle arrest, apoptosis, and senescence. While involvement of p53 in tumorigenesis is well established, recent...
-
P53 and VEGF are promising biomarkers for sorafenib efficacy in an experimental model of NASH-related HCC
The efficacy of systemic therapy for hepatocellular carcinoma (HCC) related to non-alcoholic steatohepatitis (NASH) is poorly understood. In this...
-
Bortezomib exerts its anti-cancer activity through the regulation of Skp2/p53 axis in non-melanoma skin cancer cells and C. elegans
Non-melanoma skin cancer (NMSC), encompassing basal and squamous cell carcinoma, is the most prevalent cancer in the United States. While surgical...
-
Cell differentiation modifies the p53 transcriptional program through a combination of gene silencing and constitutive transactivation
The p53 transcription factor is a master regulator of cellular responses to stress that is commonly inactivated in diverse cancer types. Despite...
-
p53 triggers mitochondrial apoptosis following DNA damage-dependent replication stress by the hepatotoxin methyleugenol
Liver cancer is one of the most frequent tumor entities worldwide, which is causally linked to viral infection, fatty liver disease, life-style...
-
Downregulation of the Rho GTPase pathway abrogates resistance to ionizing radiation in wild-type p53 glioblastoma by suppressing DNA repair mechanisms
Glioblastoma (GBM), the most common aggressive brain tumor, is characterized by rapid cellular infiltration and is routinely treated with ionizing...
-
USP7- and PRMT5-dependent G3BP2 stabilization drives de novo lipogenesis and tumorigenesis of HNSC
GTPase-activating protein-binding protein 2 (G3BP2) is a key stress granule-associated RNA-binding protein responsible for the formation of stress...
-
Severe cellular stress drives apoptosis through a dual control mechanism independently of p53
For past two decades, p53 has been claimed as the primary sensor initiating apoptosis. Under severe cellular stress, p53 transcriptional activity...
