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Exploring the crosstalk between endothelial cells, immune cells, and immune checkpoints in the tumor microenvironment: new insights and therapeutic implications
The tumor microenvironment (TME) is a highly intricate milieu, comprising a multitude of components, including immune cells and stromal cells, that...
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CRAT links cholesterol metabolism to innate immune responses in the heart
Chronic inflammation is associated with increased risk and poor prognosis of heart failure; however, the precise mechanism that provokes sustained...
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Dysregulation of innate immune signaling in animal models of spinal muscular atrophy
BackgroundSpinal muscular atrophy (SMA) is a devastating neuromuscular disease caused by hypomorphic loss of function in the survival motor neuron...
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Shrimp Immune System and Immune Responses
Shrimp, being an invertebrate, lack a vertebrate-like adaptive immune system. However, an efficient innate immune system, consisting of physical...
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DNA damage induced by CDK4 and CDK6 blockade triggers anti-tumor immune responses through cGAS-STING pathway
CDK4/6 are important regulators of cell cycle and their inhibitors have been approved as anti-cancer drugs. Here, we report a STING-dependent...
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Loss of LXN promotes macrophage M2 polarization and PD-L2 expression contributing cancer immune-escape in mice
Latexin (LXN) plays an important role in tumorigenesis and inflammatory response and as a tumor suppressor in many tumors. However, whether LXN...
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Immune Evasive Stem Cell Islets
Type 1 diabetes (T1D) is an autoimmune disease caused by the destruction of insulin-secreting β cells by the immune system (American Diabetes, A.,...
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TRIM26 deficiency enhancing liver regeneration through macrophage polarization and β-catenin pathway activation
Liver regeneration is a complex process involving the crosstalk between parenchymal and non-parenchymal cells, especially macrophages. However, the...
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Gasdermin D deficiency aborts myeloid calcium influx to drive granulopoiesis in lupus nephritis
Gasdermin D (GSDMD) is emerging as an important player in autoimmune diseases, but its exact role in lupus nephritis (LN) remains controversial....
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Herbal Medicines for the Management of Diseases on Vitamin Deficiency
Vitamins are the key ingredients for the proper functioning of the body. Though it is needed in very small quantities, this does not reflect their...
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Targeting LTA4H facilitates the resha** of the immune microenvironment mediated by CCL5 and sensitizes ovarian cancer to Cisplatin
Ovarian cancer is the most lethal and aggressive gynecological cancer with a high recurrence rate and is often diagnosed late. In ovarian cancer,...
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Role of iron in host-microbiota interaction and its effects on intestinal mucosal growth and immune plasticity in a piglet model
Iron is an essential trace element for both the host and resident microbes in the gut. In this study, iron was administered orally and parenterally...
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piRNA associates with immune diseases
PIWI-interacting RNA (piRNA) is the most abundant small non-coding RNA in animal cells, typically 26–31 nucleotides in length and it binds with PIWI...
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The Biofortification of Zinc in Legumes to Alleviate Zinc Deficiency
Micronutrient malnutrition is a serious health problem in the world that requires serious attention. About two billion people around the globe are...
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Vitamin A Deficiency, COVID-19, and Rhino-Orbital Mucormycosis (Black Fungus): An Analytical Perspective
Mucormycosis is a rare but serious opportunistic fungal disease characterized by rhino-orbito-cerebral and pulmonary involvement. It is mainly seen...
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Selenium deficiency increased duodenal permeability and decreased expression of antimicrobial peptides by activating ROS/NF-κB signal pathway in chickens
Selenium (Se) is an essential trace element for the body. Various organs of the body, including the intestine, are affected by its deficiency. Se...
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Production of iron-enriched yeast and it’s application in the treatment of iron-deficiency anemia
Iron deficiency anemia (IDA) is one of the most serious forms of malnutrition. Wild type strains of Saccharomyces cerevisiae have higher tolerance to...
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Stalled replication fork protection limits cGAS–STING and P-body-dependent innate immune signalling
Protection of stalled replication forks is crucial for cells to respond to replication stress and maintain genome stability. Genome instability and...
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Immune dysregulation in sepsis: experiences, lessons and perspectives
Sepsis is a life-threatening organ dysfunction syndrome caused by dysregulated host responses to infection. Not only does sepsis pose a serious...
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dock8 deficiency attenuates microglia colonization in early zebrafish larvae
Microglia are tissue-resident macrophages that carry out immune functions in the brain. The deficiency or dysfunction of microglia has been...
