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Traditional Herbal Medicines, Bioactive Compounds, and Plant Products as Therapeutic Approach Against Interstitial Lung Disease
Interstitial lung disease (ILD) encompasses a diverse range of respiratory disorders characterized by lung tissue inflammation and fibrosis. Its...
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HIV-Tocky system to visualize proviral expression dynamics
Determinants of HIV-1 latency establishment are yet to be elucidated. HIV reservoir comprises a rare fraction of infected cells that can survive host...
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Structural and developmental dynamics of Matrix associated regions in Drosophila melanogaster genome
BackgroundEukaryotic genome is compartmentalized into structural and functional domains. One of the concepts of higher order organization of...
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Genetic diversities in wild and cultivated populations of the two closely-related medical plants species, Tripterygium Wilfordii and T. Hypoglaucum (Celastraceae)
BackgroundThe sustainable supply of medicinal plants is important, and cultivating and domesticating them has been suggested as an optimal strategy....
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The Mediator complex regulates enhancer-promoter interactions
Enhancer-mediated gene activation generally requires physical proximity between enhancers and their target gene promoters. However, the molecular...
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Mitochondria and NLRP3 inflammasome in cardiac hypertrophy
Cardiac hypertrophy is the main adaptive response of the heart to chronic loads; however, prolonged or excessive hypertrophy promotes myocardial...
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The chromosome-level genome and functional database accelerate research about biosynthesis of secondary metabolites in Rosa roxburghii
Rosa roxburghii Tratt, a valuable plant in China with long history, is famous for its fruit. It possesses various secondary metabolites, such as...
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Chemical Characterization of Phytoconstituents for Lifestyle Diseases
Medicinal plants have been largely used for the treatment of several illnesses including lifestyle diseases. The observed pharmacological properties...
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Nanotechnology in Delivery and Targeting of Phytochemicals for Lifestyle Diseases
In many cases, conventional therapeutics are not able to cure diseases in a proper and safe manner. Conversely, plants and their derivatives have...
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A novel strategy to enhance terpenoids production using cambial meristematic cells of Tripterygium wilfordii Hook. f.
BackgroundTripterygium wilfordii Hook. f. ( T. wilfordii ) is an important medicinal plant with anti-inflammatory, immunosuppressive and anti-tumor...
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A cytochrome P450 CYP81AM1 from Tripterygium wilfordii catalyses the C-15 hydroxylation of dehydroabietic acid
Main conclusionA novel cytochrome P450 from Tripterygium wilfordii , CYP81AM1, specifically catalyses the C-15 hydroxylation of dehydroabietic acid....
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KAS-seq: genome-wide sequencing of single-stranded DNA by N3-kethoxal–assisted labeling
Transcription and its dynamics are crucial for gene expression regulation. However, very few methods can directly read out transcriptional activity...
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Phosphorylation: new star of pathogenesis and treatment in steatotic liver disease
Steatotic liver disease poses a serious threat to human health and has emerged as one of the most significant burdens of chronic liver disease...
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Nutraceuticals and Nanonutraceuticals Formulation for Chronic Disease – Cancer
Nutraceuticals are extensively explored for management of various types of cancer. They are generally regarded to be neutral and safe and are widely...
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FANCD2 promotes mitotic rescue from transcription-mediated replication stress in SETX-deficient cancer cells
Replication stress (RS) is a leading cause of genome instability and cancer development. A substantial source of endogenous RS originates from the...
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The gibberellin 13-oxidase that specifically converts gibberellin A9 to A20 in Tripterygium wilfordii is a 2-oxoglutarate-dependent dioxygenase
Main conclusion A novel GA13-oxidase of
Tripterygium wilfordii ,Tw GA13ox, is a 2-oxoglutarate-dependent dioxygenase. It specifically catalyzes the...
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Exploring the nexus of nuclear receptors in hematological malignancies
Hematological malignancies (HM) represent a subset of neoplasms affecting the blood, bone marrow, and lymphatic systems, categorized primarily into...
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Bmal1 regulates circadian expression of cytochrome P450 3a11 and drug metabolism in mice
Metabolism is a major defense mechanism of the body against xenobiotic threats. Here we unravel a critical role of Bmal1 for circadian...
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Extracellular Matrix Remodeling Enzymes as Targets for Natural Antiangiogenic Compounds
Angiogenesis, or new blood vessels formation, comprises a series of tight regulated and coordinated steps guided by the balance between proangiogenic...