Search
Search Results
-
Characterization of the chicken T cell receptor γ repertoire by high-throughput sequencing
BackgroundAs one of “γδ-high” species, chicken is an excellent model for the study of γδ T cells in non-mammalian animals. However, a comprehensive...
-
Understanding repertoire sequencing data through a multiscale computational model of the germinal center
Sequencing of B-cell and T-cell immune receptor repertoires helps us to understand the adaptive immune response, although it only provides...
-
Single-cell transcriptome and TCR profiling reveal activated and expanded T cell populations in Parkinson’s disease
Given the chronic inflammatory nature of Parkinson’s disease (PD), T cell immunity may be important for disease onset. Here, we performed single-cell...
-
Single cell dynamics of tumor specificity vs bystander activity in CD8+ T cells define the diverse immune landscapes in colorectal cancer
CD8 + T cell activation via immune checkpoint blockade (ICB) is successful in microsatellite instable (MSI) colorectal cancer (CRC) patients. By...
-
Benchmarking of T cell receptor repertoire profiling methods reveals large systematic biases
Monitoring the T cell receptor (TCR) repertoire in health and disease can provide key insights into adaptive immune responses, but the accuracy of...
-
TRUST4: immune repertoire reconstruction from bulk and single-cell RNA-seq data
We introduce the TRUST4 open-source algorithm for reconstruction of immune receptor repertoires in αβ/γδ T cells and B cells from RNA-sequencing...
-
Features of repertoire diversity and gene expression in human cytotoxic T cells following allogeneic hematopoietic cell transplantation
Cytomegalovirus reactivation is still a critical concern following allogeneic hematopoietic cell transplantation, and cellular immune reconstitution...
-
-
Characterization of the B cell receptor repertoire of patients with acute coronary syndrome
BackgroundAcute coronary syndrome (ACS) is a complex cardiovascular disease whose development involves the dysregulation of adaptive immune...
-
Single cell transcriptomics and TCR reconstruction reveal CD4 T cell response to MHC-II-restricted APOB epitope in human cardiovascular disease
Atherosclerosis is accompanied by a CD4 T cell response to apolipoprotein B (APOB). Major histocompatibility complex class II (MHC-II) tetramers can...
-
ImmunoDataAnalyzer: a bioinformatics pipeline for processing barcoded and UMI tagged immunological NGS data
BackgroundNext-generation sequencing (NGS) is nowadays the most used high-throughput technology for DNA sequencing. Among others NGS enables the...
-
Human thymoma-associated mutation of the GTF2I transcription factor impairs thymic epithelial progenitor differentiation in mice
Few human tumours present with a recurrent pathognomonic mutation in a transcription factor. Thymomas are an exception, with the majority of some...
-
High-throughput and single-cell T cell receptor sequencing technologies
T cells express T cell receptors (TCRs) composed of somatically recombined TCRα and TCRβ chains, which mediate recognition of major...
-
Discovery of tumor-reactive T cell receptors by massively parallel library synthesis and screening
T cell receptor (TCR) gene therapy is a potent form of cellular immunotherapy in which patient T cells are genetically engineered to express TCRs...
-
Can AlphaFold’s breakthrough in protein structure help decode the fundamental principles of adaptive cellular immunity?
T cells are essential immune cells responsible for identifying and eliminating pathogens. Through interactions between their T-cell antigen receptors...
-
High-throughput discovery of MHC class I- and II-restricted T cell epitopes using synthetic cellular circuits
Antigen discovery technologies have largely focused on major histocompatibility complex (MHC) class I-restricted human T cell receptors (TCRs),...
-
Yeast Display for the Identification of Peptide-MHC Ligands of Immune Receptors
T cells detect peptide antigens presented by major histocompatibility complex (MHC) proteins via their T cell receptor (TCR). The sequence diversity...
-
Butyrophilin-like 2 regulates site-specific adaptations of intestinal γδ intraepithelial lymphocytes
Tissue-resident γδ intraepithelial lymphocytes (IELs) orchestrate innate and adaptive immune responses to maintain intestinal epithelial barrier...
-
A T cell receptor targeting a recurrent driver mutation in FLT3 mediates elimination of primary human acute myeloid leukemia in vivo
Acute myeloid leukemia (AML), the most frequent leukemia in adults, is driven by recurrent somatically acquired genetic lesions in a restricted...
-
Maternal dendritic cells influence fetal allograft response following murine in-utero hematopoietic stem cell transplantation
BackgroundIntrauterine hematopoietic stem cell transplantation (IUT), potentially curative in congenital haematological disease, is often inhibited...
