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M1 macrophage-derived exosomes and their key molecule lncRNA HOTTIP suppress head and neck squamous cell carcinoma progression by upregulating the TLR5/NF-κB pathway
Exosomes serve as a crucial mode of communication between tumor-associated macrophages (TAMs) and cancer cells. This study attempted to explore the...
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Tailored graphical lasso for data integration in gene network reconstruction
BackgroundIdentifying gene interactions is a topic of great importance in genomics, and approaches based on network models provide a powerful tool...
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Genome-scale mining of root-preferential genes from maize and characterization of their promoter activity
BackgroundModification of root architecture and improvement of root resistance to stresses can increase crop productivity. Functional analyses of...
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Big Data Analysis in Bioinformatics
Biology is the science of nature’s life. It regards living things in one cell or separate cells (e.g. creatures, plants, and micro-organisms)....
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MAP4K4 mediates the SOX6-induced autophagy and reduces the chemosensitivity of cervical cancer
There are nearly 40% of cervical cancer patients showing poor response to neoadjuvant chemotherapy that can be induced by autophagy, however, the...
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GERBERA (Gerbera jamesonii Bolus ex. Hooker F.)
Plant genetic resources include primitive forms of cultivated plant species and landraces, modern cultivars, obsolete cultivars, breeding lines and...
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Bovine Reservoir of STEC and EPEC: Advances and New Contributions
Shiga toxin-producing E. coli (STECShiga-toxin producing E. coli (STEC)) and enteropathogenic E. coli (EPECEnteropathogenic E. coli (EPEC)) are...
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Artificial intelligence to deep learning: machine intelligence approach for drug discovery
Drug designing and development is an important area of research for pharmaceutical companies and chemical scientists. However, low efficacy,...
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Gene Set Approaches and Prognostic Subgroup Prediction
In this chapter, we implement Gene Set Enrichment Analysis (GSEA) to analyze microarray data. We perform Kaplan-Meier survival analysis for the...
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Omental macrophages secrete chemokine ligands that promote ovarian cancer colonization of the omentum via CCR1
The omentum is the most common site of ovarian cancer metastasis. Immune cell clusters called milky spots are found throughout the omentum. It is...
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Reciprocal impacts of telomerase activity and ADRN/MES differentiation state in neuroblastoma tumor biology
Telomere maintenance and tumor cell differentiation have been separately implicated in neuroblastoma malignancy. Their mechanistic connection is...
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Diagnosis of Genetic Disorders by DNA Analysis
DNA diagnostic tools have revolutionized modern medicine. Rapid and cost-effective technologies have changed the way genetic diseases are being...
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Aberrant Gcm1 expression mediates Wnt/β-catenin pathway activation in folate deficiency involved in neural tube defects
Wnt signaling plays a major role in early neural development. An aberrant activation in Wnt/β-catenin pathway causes defective anteroposterior...
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Oxidative ornithine metabolism supports non-inflammatory C. difficile colonization
The enteric pathogen Clostridioides difficile ( Cd ) is responsible for a toxin-mediated infection that causes more than 200,000 recorded...
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Genes and Beyond
This chapter focuses on the micro end of the spectrum after the 1992 period and examines plant science in detail. Biotechnology and genetics are...
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An evaluation of aging measures: from biomarkers to clocks
With the increasing number of aged population and growing burden of healthy aging demands, a rational standard for evaluation aging is in urgent...
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GERBERA (Gerbera jamesonii Bolus ex. Hooker F.)
Plant genetic resources include primitive forms of cultivated plant species and landraces, modern cultivars, obsolete cultivars, breeding lines and...
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Transcriptome comparative analysis of ovarian follicles reveals the key genes and signaling pathways implicated in hen egg production
BackgroundOvarian follicle development plays an important role in determination of poultry egg production. The follicles at the various developmental...
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Regulated IFN signalling preserves the stemness of intestinal stem cells by restricting differentiation into secretory-cell lineages
Intestinal stem cells (ISCs) are located at the crypt base and fine-tune the balance of their self-renewal and differentiation
1 ,2 , but the...