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Identification of ulcerative colitis-specific immune cell signatures from public single-cell RNA-seq data
BackgroundSingle-cell RNA-seq enabled microscopic studies on tissue microenvironment of many diseases. Inflammatory bowel disease, an autoimmune...
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Functional characterization of CD49f+ hepatic stem/progenitor cells in adult mice liver
Hepatic Stem/progenitor cells (HSPCs) have gained a large amount of interest for treating acute liver disease. However, the isolation and...
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Over-expression of lncRNA TMEM161B-AS1 promotes the malignant biological behavior of glioma cells and the resistance to temozolomide via up-regulating the expression of multiple ferroptosis-related genes by sponging hsa-miR-27a-3p
A growing body of evidence suggests that long-chain non-coding RNA (lncRNA) plays an important role in the malignant biological behavior and drug...
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Expansion of human bone marrow-derived mesenchymal stromal cells with enhanced immunomodulatory properties
BackgroundMesenchymal stromal cells (MSCs) have broad potential as a cell therapy including for the treatment of drug-resistant inflammatory...
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Exosomal USP13 derived from microvascular endothelial cells regulates immune microenvironment and improves functional recovery after spinal cord injury by stabilizing IκBα
Spinal cord injury (SCI) can result in irreversible sensory and motor disability with no effective treatment currently. After SCI, infiltrated...
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Role of NLRP3 inflammasome in central nervous system diseases
The central nervous system (CNS) is the most delicate system in human body, with the most complex structure and function. It is vulnerable to trauma,...
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Signatures of co-deregulated genes and their transcriptional regulators in colorectal cancer
The deregulated genes in colorectal cancer (CRC) vary significantly across different studies. Thus, a systems biology approach is needed to identify...
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Small RNA sequencing and identification of papaya (Carica papaya L.) miRNAs with potential cross-kingdom human gene targets
Several studies have demonstrated potential role of plant-derived miRNAs in cross-kingdom species relationships by transferring into non-plant host...
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Pro-death signaling of cytoprotective heat shock factor 1: upregulation of NOXA leading to apoptosis in heat-sensitive cells
Heat shock can induce either cytoprotective mechanisms or cell death. We found that in certain human and mouse cells, including spermatocytes,...
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Integrated analysis of lncRNA-miRNA-mRNA ceRNA network in human aortic dissection
BackgroundMany studies on long chain non-coding RNAs (lncRNAs) are published in recent years. But the roles of lncRNAs in aortic dissection (AD) are...
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Markers of Stem Cells
The role of stem cells in regenerative medicine is imperative. The population of these stem cells is infinitesimally small and therefore, suitable...
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Loss of thyroid gland circadian PER2 rhythmicity in aged mice and its potential association with thyroid cancer development
Molecular clocks operate in peripheral tissues, including endocrine glands, and play important regulatory roles in this context. However, potential...
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Maternal Undernutrition Induces Cell Signalling and Metabolic Dysfunction in Undifferentiated Mouse Embryonic Stem Cells
Peri-conceptional environment can induce permanent changes in embryo phenotype which alter development and associate with later disease...
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Mesenchymal stem cells exert renoprotection via extracellular vesicle-mediated modulation of M2 macrophages and spleen-kidney network
Adipose-derived mesenchymal stem cells (ASCs) have shown therapeutic potentials against refractory diseases. However, the detailed therapeutic...
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A placental model of SARS-CoV-2 infection reveals ACE2-dependent susceptibility and differentiation impairment in syncytiotrophoblasts
SARS-CoV-2 infection causes COVID-19. Several clinical reports have linked COVID-19 during pregnancy to negative birth outcomes and placentitis....
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P. aeruginosa type III and type VI secretion systems modulate early response gene expression in type II pneumocytes in vitro
BackgroundLung airway epithelial cells are part of innate immunity and the frontline of defense against bacterial infections. During infection,...
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Redifferentiated cardiomyocytes retain residual dedifferentiation signatures and are protected against ischemic injury
Cardiomyocyte proliferation and dedifferentiation have fueled the field of regenerative cardiology in recent years, whereas the reverse process of...
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Metabolite Effect on Angiogenesis: Insights from Transcriptome Analysis
Metabolic status of the cells is important in the expression of the angiogenic phenotype in endothelial cells. Our earlier studies demonstrated the...
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CircRNA: a rising star in gastric cancer
In recent years, a large number of circRNAs have been identified in mammalian cells with high-throughput sequencing technologies and bioinformatics....
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A novel method to identify gene interaction patterns
BackgroundGene interaction patterns, including modules and motifs, can be used to identify cancer specific biomarkers and to reveal the mechanism of...
