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Direct enhancement of viral neutralising antibody potency by the complement system: a largely forgotten phenomenon
Neutralisation assays are commonly used to assess vaccine-induced and naturally acquired immune responses; identify correlates of protection; and...
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Global Antiphospholipid Syndrome Score (GAPSS) in Patients with Systemic Lupus Erythematosus
AbstractThe Global Antiphospholipid Syndrome Score (GAPSS) is a tool proposed to quantify the risk of clinical manifestations associated with...
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Properties of Extracellular Protease—Regulator of Hemostasis Produced by Micromycete Aspergillus tabacinus
AbstractThe extracellular protease with protein C-like and plasmin-like activities was isolated from the culture fluid of the micromycete A. tabacinus ...
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Predictive value of lipoprotein(a) for left atrial thrombus or spontaneous echo contrast in non-valvular atrial fibrillation patients with low CHA2DS2-VASc scores: a cross-sectional study
ObjectiveCurrent guidelines are debated when it comes to starting anticoagulant therapy in patients with non-valvular atrial fibrillation (NVAF) and...
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Basic Principles of Specimen Collection
Collecting samples is an important part of animal experiments. There are not any fixed rules, only general principles. Samples to collect are based...
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Comparative Studies of Complex Products Based on Heparins of Animal and Plant Origin
AbstractComplex preparations based on heparins of animal and vegetable origin with the inclusion of glutamic acid in a weight ratio of 1 : 4 were...
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Draft genome sequences of Hirudo medicinalis and salivary transcriptome of three closely related medicinal leeches
BackgroundSalivary cell secretion (SCS) plays a critical role in blood feeding by medicinal leeches, making them of use for certain medical purposes...
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Anticoagulation Management for Mechanical Valves in the On-X Era
The first mechanical aortic valve was surgically implanted 70 years ago. As the engineering of mechanical heart valves and surgical survival...
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Pathophysiology, risk, diagnosis, and management of venous thrombosis in space: where are we now?
The recent incidental discovery of an asymptomatic venous thrombosis (VT) in the internal jugular vein of an astronaut on the International Space...
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Managing non-target wildlife mortality whilst using rodenticides to eradicate invasive rodents on islands
Invasive rodents are one of the greatest threats to island biodiversity. Eradicating these species from islands has become increasingly practicable...
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Effect of Heparin on the Formation and Healing of Gastric Ulcers Induced by Acetic Acid Application on the Gastric Mucosa in Rats
AbstractThe key factor in maintaining the integrity of the gastric mucosa is its normal blood supply, respectively, the use of drugs that improve it,...
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Methods for the Production of Recombinant Heparosan , a Critical Heparin Precursor, from Nonpathogenic E. coli Strains
Heparin is an essential anticoagulant drug discovered over a century ago. Heparin is the second most highly used natural drug and remains a mainstay...
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The relationship between serum coagulation parameters and the recurrence of chronic subdural hematoma
The aim is to investigate the relationship between serum coagulation parameters (PT, APTT, D-D and FDP) before hospitalization and recurrence of...
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A simplified protocol for profiling heparin-contaminated circulating miRNAs: by microfluidic array
Peripheral blood is a valuable, non-invasive source of biomarkers which include circulating miRNAs. Using microfluidic array-based techniques, miRNAs...
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Molecular cross-talk between long COVID-19 and Alzheimer’s disease
The long COVID (coronavirus disease), a multisystemic condition following severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, is...
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Coagulopathy is Initiated with Endothelial Dysfunction and Disrupted Fibrinolysis in Patients with COVID-19 Disease
A substantial group of patients suffer from Covid-19 (CAC) coagulopathy and are presented with thrombosis. The pathogenesis involved in CAC is not...
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Enzymatic Sequencing of Heparin Oligosaccharides Using Exolyase
Heparin/heparan sulfate (HP/HS) is a class of acidic polysaccharides with many potential medical applications, especially HP, and its derivatives,...