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Epigenetics of Rhinovirus
Epigenetics is a moderately novel field that explores the genetic and non-genetic components of transmissible phenotypic changes, which are commonly...
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Establishment of RT-RPA-Cas12a assay for rapid and sensitive detection of human rhinovirus B
Human rhinovirus B (HRV-B) is a major human viral pathogen that can be responsible for various kinds of infections. Due to the health risks...
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Molecular and clinical characteristics related to rhinovirus infection in Brasília, Brazil
IntroductionHuman rhinovirus (HRV) is one of the most common human viral pathogens related to infections of the upper and lower respiratory tract,...
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Exploring the Human Virome: Composition, Dynamics, and Implications for Health and Disease
Humans are colonized by large number of microorganisms—bacteria, fungi, and viruses. The overall genome of entire viruses that either lives on or...
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Altered transcriptional and chromatin responses to rhinovirus in bronchial epithelial cells from adults with asthma
There is a life-long relationship between rhinovirus (RV) infection and the development and clinical manifestations of asthma. In this study we...
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Individual subunits of a rhinovirus causing common cold exhibit largely different protein-RNA contact site conformations
Rhinoviruses cause the common cold. They are icosahedral, built from sixty copies each of the capsid proteins VP1 through VP4 arranged in a pseudo...
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Prevalence of antibodies against human respiratory viruses potentially involving anthropozoonoses in wild bonobos
One of the current threats to the bonobo ( Pan paniscus ), a highly endangered ape species only found in the Democratic Republic of the Congo, are...
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Seasonal respiratory virus trends in pediatric patients during the COVID-19 pandemic in Brazil
Acute respiratory infections are a constant public health problem causing childhood morbidity and mortality worldwide. Reported cases of major...
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Surfaceome CRISPR screen identifies OLFML3 as a rhinovirus-inducible IFN antagonist
BackgroundRhinoviruses (RVs) cause more than half of common colds and, in some cases, more severe diseases. Functional genomics analyses of RVs using...
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Pan-sarbecovirus prophylaxis with human anti-ACE2 monoclonal antibodies
Human monoclonal antibodies (mAbs) that target the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein have been isolated from...
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Causal identification of single-cell experimental perturbation effects with CINEMA-OT
Recent advancements in single-cell technologies allow characterization of experimental perturbations at single-cell resolution. While methods have...
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A nanobody-based strategy for rapid and scalable purification of human protein complexes
The isolation of proteins in high yield and purity is a major bottleneck for the analysis of their three-dimensional structure, function and...
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Patterns and predictors of positive multiplex polymerase chain reaction respiratory panel among patients with acute respiratory infections in a single center in Lebanon
BackgroundInfectious agents associated with community-acquired acute respiratory infections (ARIs) remain understudied in Lebanon. We aim to assess...
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Respiratory viral infections other than SARS CoV-2 among the North Indian patients presenting with acute respiratory illness during the first COVID-19 wave
Acute respiratory infections due to viral or bacterial etiology can cause 60 deaths per one lakh population. Viral etiology is more common as...
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Purification of Recombinant Human PARG and Activity Assays
The purification of poly(ADP-ribose) glycohydrolase (PARG) from overexpressing bacteria Escherichia coli is described here as a fast and reproducible...
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Transport and inhibition mechanism of the human SGLT2–MAP17 glucose transporter
Sodium–glucose cotransporter 2 (SGLT2) is imporant in glucose reabsorption. SGLT2 inhibitors suppress renal glucose reabsorption, therefore reducing...
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The Human Microbiome and Respiratory Diseases
The composition of the respiratory tract microbiota has been actively studied around the world. In this article, we have analyzed and summarized the...
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Reconstitution of Human CCR4-NOT Complex from Purified Proteins and an Assay of Its Deadenylation Activity
We describe protocols to produce and reconstitute an active human CCR4-NOT complex. Individual recombinant subunits are expressed in E. coli or...
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Spread of Pathogens Causing Respiratory Viral Diseases Before and During CoVID-19 Pandemic in Kazakhstan
Analyze clinical samples collected and determine the etiology of viral pathogens and the dynamics of their spread. Acute respiratory viral infections...
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Using the IPTG-Inducible Pgrac212 Promoter for Overexpression of Human Rhinovirus 3C Protease Fusions in the Cytoplasm of Bacillus subtilis Cells
Expression and secretion of recombinant proteins in the endotoxin-free bacterium, Bacillus subtilis , has been thoroughly studied, but overexpression...
