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Identification of volatile metabolites produced from levodopa metabolism by different bacteria strains of the gut microbiome
Interspecies pathways in the gut microbiome have been shown to metabolize levodopa, the primary treatment for Parkinson’s disease, and reduce its...
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Biochemical characterisation and production kinetics of high molecular-weight (HMW) putative antibacterial proteins of insect pathogenic Brevibacillus laterosporus isolates
BackgroundBacterial genomes often encode structures similar to phage capsids (encapsulins) and phage tails which can be induced spontaneously or...
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An altered uterine microbiota with endometrial hyperplasia
BackgroundEndometrial hyperplasia (EH) is a precursor to endometrial cancer, and the role of the microbiome in its development is unclear.
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A dynamic subpopulation of CRISPR–Cas overexpressers allows Streptococcus pyogenes to rapidly respond to phage
Many CRISPR–Cas (clustered regularly interspaced short palindromic repeats and CRISPR-associated protein) systems, which provide bacteria with...
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Bacterial reprogramming of tick metabolism impacts vector fitness and susceptibility to infection
Arthropod-borne pathogens are responsible for hundreds of millions of infections in humans each year. The blacklegged tick, Ixodes scapularis , is the...
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A safe, effective and adaptable live-attenuated SARS-CoV-2 vaccine to reduce disease and transmission using one-to-stop genome modifications
Approved vaccines are effective against severe COVID-19, but broader immunity is needed against new variants and transmission. Therefore, we...
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Thiolated chitosan nanoparticles encapsulated nisin and selenium: antimicrobial/antibiofilm/anti-attachment/immunomodulatory multi-functional agent
BackgroundThe increase in the resistance of bacterial strains to antibiotics has led to research into the bactericidal potential of non-antibiotic...
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Pathogenomics analysis of high-risk clone ST147 multidrug-resistant Klebsiella pneumoniae isolated from a patient in Egypt
BackgroundThe emergence of multi-drug-resistant Klebsiella pneumoniae (MDR-KP) represents a serious clinical health concern. Antibiotic resistance...
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Green synthesis of zinc oxide nanoparticles (ZnO-NPs) by Streptomyces baarnensis and its active metabolite (Ka): a promising combination against multidrug-resistant ESKAPE pathogens and cytotoxicity
Various eco-friendly techniques are being researched for synthesizing ZnO-NPs, known for their bioactivity. This study aimed at biosynthesizing...
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Evaluating the probiotic effects of spraying lactiplantibacillus plantarum P-8 in neonatal piglets
BackgroundGut microbes play an important role in the growth and health of neonatal piglets. Probiotics can promote the healthy growth of neonatal...
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Biocontrol potential and growth-promoting effect of endophytic fungus Talaromyces muroii SD1-4 against potato leaf spot disease caused by Alternaria alternata
BackgroundAlternaria alternata is the primary pathogen of potato leaf spot disease, resulting in significant potato yield losses globally....
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Design of a two functional permeable reactive barrier for synergistic enzymatic and microbial bioremediation of phenol-contaminated waters: laboratory column evaluation
The present study aimed to develop a system using a combination of enzymatic and microbial degradation techniques for removing phenol from...
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Evaluation of vaccine candidates against Rhodococcus equi in BALB/c mice infection model: cellular and humoral immune responses
Rhodococcus equi ( R. equi ) is a zoonotic opportunistic pathogen that mainly causes fatal lung and extrapulmonary abscesses in foals and...
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Environmentally dependent interactions shape patterns in gene content across natural microbiomes
Sequencing surveys of microbial communities in hosts, oceans and soils have revealed ubiquitous patterns linking community composition to...
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CRISPR-based functional profiling of the Toxoplasma gondii genome during acute murine infection
Examining host–pathogen interactions in animals can capture aspects of infection that are obscured in cell culture. Using CRISPR-based screens, we...
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Multikingdom and functional gut microbiota markers for autism spectrum disorder
Associations between the gut microbiome and autism spectrum disorder (ASD) have been investigated although most studies have focused on the bacterial...
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Evaluating the effects of temperature and agitation on biofilm formation of bacterial pathogens isolated from raw cow milk
ObjectivesTo study the effect of agitation and temperature on biofilm formation (cell aggregates embedded within a self-produced matrix) by...
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Genomic characterization of multi drug resistant ESBL-producing Escherichia coli isolates from patients and patient environments in a teaching hospital in Ghana
BackgroundESBL-producing Escherichia coli pose a growing health risk in community and healthcare settings. We investigated the resistome, virulome,...
