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LKB1 biology: assessing the therapeutic relevancy of LKB1 inhibitors
Liver Kinase B1 (LKB1), encoded by Serine-Threonine Kinase 11 ( STK11 ), is a master kinase that regulates cell migration, polarity, proliferation, and...
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Integrin αVβ1-activated PYK2 promotes the progression of non-small-cell lung cancer via the STAT3-VGF axis
BackgroundNon-small-cell lung cancer (NSCLC) accounts for 80–85% of all lung cancer and is the leading cause of cancer-related deaths globally....
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Advances in the understanding of heat shock proteins and their functions in reducing abiotic stress in plants
Abiotic stresses such as high temperature, excessive cold, flood, salinity, and drought disturb the normal growth and production which aggravate...
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A rare olive compound oleacein functions as a TrkB agonist and mitigates neuroinflammation both in vitro and in vivo
BackgroundNeuroinflammation is widely acknowledged as a characteristic feature of almost all neurological disorders and specifically in depression-...
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NEDD4L mediates ITGB4 ubiquitination and degradation to suppress esophageal carcinoma progression
The ubiquitination-mediated protein degradation exerts a vital role in the progression of multiple tumors. NEDD4L, which belongs to the E3 ubiquitin...
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ER stress inhibition enhances formation of triacylglcerols and protects endothelial cells from lipotoxicity
Elevated concentrations of palmitate in serum of obese individuals can impair endothelial function, contributing to development of cardiovascular...
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Activation of AMPK inhibits cervical cancer growth by hyperacetylation of H3K9 through PCAF
BackgroundDysregulation in histone acetylation, a significant epigenetic alteration closely associated with major pathologies including cancer,...
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Interleukin-22 receptor 1-mediated stimulation of T-type Ca2+ channels enhances sensory neuronal excitability through the tyrosine-protein kinase Lyn-dependent PKA pathway
BackgroundInterleukin 24 (IL-24) has been implicated in the nociceptive signaling. However, direct evidence and the precise molecular mechanism...
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Gasdermin D deficiency aborts myeloid calcium influx to drive granulopoiesis in lupus nephritis
Gasdermin D (GSDMD) is emerging as an important player in autoimmune diseases, but its exact role in lupus nephritis (LN) remains controversial....
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GLUT1 promotes cell proliferation via binds and stabilizes phosphorylated EGFR in lung adenocarcinoma
BackgroundWhile previous studies have primarily focused on Glucose transporter type 1 (GLUT1) related glucose metabolism signaling, we aim to...
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STING agonists as promising vaccine adjuvants to boost immunogenicity against SARS-related coronavirus derived infection: possible role of autophagy
As a major component of innate immunity and a positive regulator of interferons, the Stimulator of interferon gene (STING) has an immunotherapy...
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Human amnion mesenchymal stem cells promote endometrial repair via paracrine, preferentially than transdifferentiation
BackgroundIntrauterine adhesion (IUA) is one of the most severe causes of infertility in women of childbearing age with injured endometrium secondary...
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Low concentrations of saracatinib promote definitive endoderm differentiation through inhibition of FAK-YAP signaling axis
AbstractOptimizing the efficiency of definitive endoderm (DE) differentiation is necessary for the generation of diverse organ-like structures. In...
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Ephs in cancer progression: complexity and context-dependent nature in signaling, angiogenesis and immunity
Eph receptors constitute the largest family of receptor tyrosine kinases, comprising 14 distinct members classified into two subgroups: EphAs and...
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Deciphering the dual nature of nesfatin-1: a tale of zinc ion’s Janus-faced influence
BackgroundNucleobindin-2 (Nucb2) and nesfatin-1 (N1) are widely distributed hormones that regulate numerous physiological processes, from energy...
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SIRT1 regulates hepatic vldlr levels
BackgroundEndoplasmic reticulum (ER) stress-mediated increases in the hepatic levels of the very low-density lipoprotein (VLDL) receptor (VLDLR)...
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Diverse roles of SARS-CoV-2 Spike and Nucleocapsid proteins in EndMT stimulation through the TGF-β-MRTF axis inhibited by aspirin
BackgroundThe SARS-CoV-2 virus causes severe COVID-19 in one-fifth of patients. In addition to high mortality, infection may induce respiratory...
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Emphasizing the role of wheat circular RNA in defense response against stripe rust disease
Circular RNAs (CircRNAs) represent a subset of non-coding RNAs (ncRNAs) discerned by deep sequencing, predominantly within plant cells. They serve...
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Purification and characterization of a lectin from Trigonella foenum-graecum (fenugreek) seeds and its porphyrin binding studies
Lectin (TfgL) was purified from the seeds of Trigonella foenum-graecum (Fenugreek) belonging to fabaceae family by ammonium sulphate precipitation,...
