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Integrated transcriptome and microRNA analysis reveals molecular responses to high-temperature stress in the liver of American shad (Alosa sapidissima)
BackgroundFish reproduction, development and growth are directly affected by temperature, investigating the regulatory mechanisms behind high...
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Predicting glycan structure from tandem mass spectrometry via deep learning
Glycans constitute the most complicated post-translational modification, modulating protein activity in health and disease. However, structural...
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Entry of ZSWIM4 to the nucleus is crucial for its inhibition of KIT and BMAL1 in gastrointestinal stromal tumors
BackgroundZinc finger SWIM-type containing 4 (ZSWIM4) is a zinc finger protein with its function largely uncharacterized. In this study, we aimed to...
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Unexpected regulatory functions of cyprinid Viperin on inflammation and metabolism
BackgroundViperin, also known as radical S-adenosyl-methionine domain containing protein 2 (RSAD2), is an interferon-inducible protein that is...
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Rare variant analyses validate known ALS genes in a multi-ethnic population and identifies ANTXR2 as a candidate in PLS
BackgroundAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting over 300,000 people worldwide. It is characterized by the...
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Genome-wide association analysis identify candidate genes for feed efficiency and growth traits in Wenchang chickens
BackgroundWenchang chickens are one of the most popular local chicken breeds in the Chinese chicken industry. However, the low feed efficiency is the...
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Early detection of breast cancer through the diagnosis of Nipple Aspirate Fluid (NAF)
The development of breast cancer has been mainly reported in women who have reached the post-menopausal stage; therefore, it is the primary factor...
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Genome-wide identification of the Q-type C2H2 zinc finger protein gene family and expression analysis under abiotic stress in lotus (Nelumbo nucifera G.)
BackgroundLotus ( Nelumbo nucifera G.) is an important aquatic plant with high ornamental, economic, cultural and ecological values, but abiotic...
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Molecular genetic diversity and linkage disequilibrium structure of the Egyptian faba bean using Single Primer Enrichment Technology (SPET)
Faba bean is an important legume crop. The genetic diversity among faba bean genotypes is very important for the genetic improvement of target...
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The genomic landscape of Ménière's disease: a path to endolymphatic hydrops
BackgroundMénière's disease (MD) is a disorder of the inner ear that causes episodic bouts of severe dizziness, roaring tinnitus, and fluctuating...
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Generation and transcriptomic characterization of MIR137 knockout miniature pig model for neurodevelopmental disorders
BackgroundNeurodevelopmental disorders (NDD), such as autism spectrum disorders (ASD) and intellectual disorders (ID), are highly debilitating...
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Genes divided according to the relative position of the longest intron show increased representation in different KEGG pathways
Despite the fact that introns mean an energy and time burden for eukaryotic cells, they play an irreplaceable role in the diversification and...
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UnCoVar: a reproducible and scalable workflow for transparent and robust virus variant calling and lineage assignment using SARS-CoV-2 as an example
BackgroundAt a global scale, the SARS-CoV-2 virus did not remain in its initial genotype for a long period of time, with the first global reports of...
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Genetic correlation between smoking behavior and gastroesophageal reflux disease: insights from integrative multi-omics data
BackgroundObservational studies have preliminarily revealed an association between smoking and gastroesophageal reflux disease (GERD). However,...
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Microvascular destabilization and intricated network of the cytokines in diabetic retinopathy: from the perspective of cellular and molecular components
Microvascular destabilization is the primary cause of the inner blood-retinal barrier (iBRB) breakdown and increased vascular leakage in diabetic...
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In vitro and in vivo studies on exogenous polyamines and α-difluoromethylornithine to enhance bone formation and suppress osteoclast differentiation
Exogenous polyamines, including putrescine (PUT), spermidine (SPD), and spermine (SPM), and the irreversible inhibitor of the rate-limiting enzyme...
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Investigating diversity and similarity between CBM13 modules and ricin-B lectin domains using sequence similarity networks
BackgroundThe CBM13 family comprises carbohydrate-binding modules that occur mainly in enzymes and in several ricin-B lectins. The ricin-B lectin...
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Construction of a high-density genetic map and QTL localization of body weight and wool production related traits in Alpine Merino sheep based on WGR
BackgroundThe Alpine Merino is a new breed of fine-wool sheep adapted to the cold and arid climate of the plateau in the world. It has been...
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Genomic determinants, architecture, and constraints in drought-related traits in Corymbia calophylla
BackgroundDrought adaptation is critical to many tree species persisting under climate change, however our knowledge of the genetic basis for trees...
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The effect of vitamin E on ethanol-induced liver damage in rats
Ethanol can have harmful effects on the development of the embryos. The aim of this study was to evaluate the effect of vitamin E, as an antioxidant,...
