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Proteome-scale tagging and functional screening in mammalian cells by ORFtag
The systematic determination of protein function is a key goal of modern biology, but remains challenging with current approaches. Here we present...
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Microsecond time-resolved X-ray scattering by utilizing MHz repetition rate at second-generation XFELs
Detecting microsecond structural perturbations in biomolecules has wide relevance in biology, chemistry and medicine. Here we show how MHz repetition...
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Proteome profiling of cutaneous leishmaniasis lesions due to dermotropic Leishmania donovani in Sri Lanka
BackgroundCharacterization of the host response in cutaneous leishmaniasis (CL) through proteome profiling has gained limited insights into...
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Functional and evolutionary comparative analysis of the DIR gene family in Nicotiana tabacum L. and Solanum tuberosum L.
BackgroundThe dirigent ( DIR ) genes encode proteins that act as crucial regulators of plant lignin biosynthesis. In Solanaceae species, members of...
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Population genetic structure of Culex tritaeniorhynchus in different types of climatic zones in China
BackgroundCulex tritaeniorhynchus is widely distributed in China, from Hainan Island in the south to Heilongjiang in the north, covering tropical,...
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Unraveling the genomic secrets of Tritonibacter mobilis AK171: a plant growth-promoting bacterium isolated from Avicennia marina
The scarcity of freshwater resources resulting in a significant yield loss presents a pressing challenge in agriculture. To address this issue,...
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Investigation of in vitro biological activity of young Hordeum vulgare leaf in correlation with its bioactive compounds
Young shoots of cereals are widely regarded as superfoods with health benefits attributed to their potential antioxidant activity and...
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CRISPR-array-mediated imaging of non-repetitive and multiplex genomic loci in living cells
Dynamic imaging of genomic loci is key for understanding gene regulation, but methods for imaging genomes, in particular non-repetitive DNAs, are...
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PEGylation renders carnosine resistant to hydrolysis by serum carnosinase and increases renal carnosine levels
Carnosine’s protective effect in rodent models of glycoxidative stress have provided a rational for translation of these findings in therapeutic...
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quantms: a cloud-based pipeline for quantitative proteomics enables the reanalysis of public proteomics data
The volume of public proteomics data is rapidly increasing, causing a computational challenge for large-scale reanalysis. Here, we introduce quantms (
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Identification and characterization of the RcTCP gene family and its expression in response to abiotic stresses in castor bean
BackgroundThe TCP ( teosinte branched1/cincinnata/proliferating cell factor ) family plays a prominent role in plant development and stress responses....
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Systematic comparison of sequencing-based spatial transcriptomic methods
Recent developments of sequencing-based spatial transcriptomics (sST) have catalyzed important advancements by facilitating transcriptome-scale...
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Decoding the role of DNA methylation in allergic diseases: from pathogenesis to therapy
Allergic diseases, characterized by a broad spectrum of clinical manifestations and symptoms, encompass a significant category of IgE-mediated atopic...
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Genetic diversity and population structure of wheat landraces in Southern Winter Wheat Region of China
BackgroundWheat landraces are considered a valuable source of genetic diversity for breeding programs. It is useful to evaluate the genetic diversity...
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Gapr for large-scale collaborative single-neuron reconstruction
Whole-brain analysis of single-neuron morphology is crucial for unraveling the complex structure of the brain. However, large-scale neuron...
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Genome-wide identification and molecular evolution of Dof transcription factors in Cyperus esculentus
Dof transcription factor family in Cyperus esculentus genome was identified and analyzed using bioinformatics. The analysis results revealed that C.esculentus...
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Metabolomic and transcriptomic analyses of peach leaves and fruits in response to pruning
BackgroundPruning is an important cultivation management option that has important effects on peach yield and quality. However, the effects of...
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Development of pre-implantation genetic testing protocol for monogenic disorders (PGT-M) of Hb H disease
Hb H disease is the most severe form of α-thalassemia compatible with post-natal life. Compound heterozygous α 0 -thalassemia − SEA deletion/α + -thalassemia...
