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Lifelong longitudinal assessment of the contribution of multi-fractal fluctuations to heart rate and heart rate variability in aging mice: role of the sinoatrial node and autonomic nervous system
Aging is a major risk factor for sinoatrial node (SAN) dysfunction, which can impair heart rate (HR) control and heart rate variability (HRV). HR and...
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A systematic review of diet and medication use among centenarians and near-centenarians worldwide
Centenarians represent a phenomenon of successful aging. This systematic review aimed to understand lifestyles and health practices, focusing on diet...
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Association of physical function with connectivity in the sensorimotor and dorsal attention networks: why examining specific components of physical function matters
Declining physical function with aging is associated with structural and functional brain network organization. Gaining a greater understanding of...
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Coffee consumption and cardiometabolic health: a comprehensive review of the evidence
This review provides a comprehensive synthesis of longitudinal observational and interventional studies on the cardiometabolic effects of coffee...
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The performance of metabolomics-based prediction scores for mortality in older patients with solid tumors
Prognostic information is needed to balance benefits and risks of cancer treatment in older patients. Metabolomics-based scores were previously...
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WTAP/IGF2BP3-mediated GBE1 expression accelerates the proliferation and enhances stemness in pancreatic cancer cells via upregulating c-Myc
BackgroundPancreatic cancer (PC) is one of the most malignant cancers with highly aggressiveness and poor prognosis. N6-methyladenosine (m6A) have...
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Impairment of α-tubulin and F-actin interactions of GJB3 induces aneuploidy in urothelial cells and promotes bladder cancer cell invasion
BackgroundWe have previously identified an unsuspected role for GJB3 showing that the deficiency of this connexin protein induces aneuploidy in human...
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Aging is associated with sex-specific alteration in the expression of genes encoding for neuroestradiol synthesis and signaling proteins in the mouse trigeminal somatosensory input
Pain perception is influenced by sex and aging, with previous studies indicating the involvement of aromatase, the estradiol synthase enzyme, in...
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RUNX1, FUS, and ELAVL1-induced circPTPN22 promote gastric cancer cell proliferation, migration, and invasion through miR-6788-5p/PAK1 axis-mediated autophagy
BackgroundAn increasing number of studies have demonstrated the association of circular RNAs (circRNAs) with the pathological processes of various...
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Antimicrobial Peptides: Potential Alternative to Antibiotics and Overcoming Limitations for Future Therapeutic Applications
Among all health-related issues, the rising concerns about drug resistance led to the look for alternative pharmaceutical drugs that are effective...
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Exploring the role of microRNAs as diagnostic and prognostic biomarkers in canine mammary tumors
Canine mammary tumors (CMTs) represent a significant health concern in dogs, with a high incidence among intact female dogs. CMTs are a promising...
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Extended lifespan in female Drosophila melanogaster through late-life calorie restriction
Calorie restriction has many beneficial effects on healthspan and lifespan in a variety of species. However, how late in life application of caloric...
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LncRNA TRPM2-AS promotes endometrial carcinoma progression and angiogenesis via targeting miR-497-5p/SPP1 axis
BackgroundAnti-angiogenic therapy has become one of the effective treatment methods for tumors. Long noncoding RNAs (lncRNAs) are emerging as...
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Genetic and environmental determinants of bone quality: a cross-sectional analysis of the Hungarian Twin Registry
There is abundant evidence that bone mineral content is highly heritable, while the heritability of bone quality (i.e. trabecular bone score [TBS]...
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Plasma metabolomic and lipidomic profiles accurately classify mothers of children with congenital heart disease: an observational study
IntroductionCongenital heart disease (CHD) is the most common congenital anomaly, representing a significant global disease burden. Limitations exist...
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Weissellicin LM85 Purified from Weissella confusa LM85 Effluxes Potassium Ions and Depletes Proton Motive Force in Escherichia coli ATCC 25922
Bacteriocins are membrane-acting peptides and generally kill closely related bacteria using pore formation. In this study, we have studied a...
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Impact of periodontal disease on cognitive disorders, dementia, and depression: a systematic review and meta-analysis
A growing body of research suggested that there was a link between poor periodontal health and systemic diseases, particularly with the early...
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A specific super-enhancer actuated by berberine regulates EGFR-mediated RAS–RAF1–MEK1/2–ERK1/2 pathway to induce nasopharyngeal carcinoma autophagy
Nasopharyngeal carcinoma (NPC), primarily found in the southern region of China, is a malignant tumor known for its highly metastatic...
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Plasma metabolites in childhood Burkitt lymphoma cases and cancer-free controls in Uganda
IntroductionBurkitt lymphoma (BL) is an aggressive non-Hodgkin lymphoma associated with Plasmodium falciparum and Epstein-Barr virus, both of which...
