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Blockade of PD-1 and TIM-3 Ameliorates CD8+ T Cell Exhaustion in a Mouse Model of Chronic Myeloid Leukemia
The immune system plays a pivotal role in controlling chronic myeloid leukemia (CML). CD8 + T cell exhaustion results in reduced effectiveness of T...
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Biotic environment reinforcing the pertinacious clinically relevant COVID-19 associated mucormycosis: First report from Kashmir valley, India
Immuno-compromised COVID-19 patients being treated with glucocorticoids like Dexamethasone for prolonged periods had led to the surge of...
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Deletion of IRC19 Causes Defects in DNA Double-Strand Break Repair Pathways in Saccharomyces cerevisiae
DNA double-strand break (DSB) repair is a fundamental cellular process crucial for maintaining genome stability, with homologous recombination and...
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Nanoarchitectonics for synergistic activity of multimetallic nanohybrids as a possible approach for antimicrobial resistance (AMR)
The global threat posed by antimicrobial resistance (AMR) to public health is an immensurable problem. The effectiveness of treating infections would...
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Conversion of polyploid and alloploid Saccharomyces sensu stricto strains to leu2 mutants by genome DNA editing
AbstractA large number of recombinant plasmids for the yeast Saccharomyces cerevisiae have been constructed and accumulated over the past four...
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Airways Relaxant and Antiasthmatic Activity of Aconitum heterophyllum Wall ex Royle. Roots: A Mechanistic Insight
Aconitum heterophyllum Wall ex Royle. (Ranunculaceae) is a traditional medicinal herb that has shown extensive pharmacological potential to treat...
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Biogenic synthesis and characterization of gold nanoparticles using transformed mesophilic Escherichia coli BL21 and thermophilic Thermus thermophilus HB27
Gold nanoparticles have numerous applications, many of which are notable in industries. The biosynthesis of gold nanoparticles offers an easy,...
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Antimicrobial efficacy and amino acid substitutions associated with susceptibility to the tellurium compound AS101 against Haemophilus influenzae and Haemophilus parainfluenzae
The tellurite toxicity in Haemophilus influenzae and H. parainfluenzae remains unclear. To understand the potential of tellurite as a therapeutic...
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Composition of the whiteflies microbiome in populations with and without insecticide applications in Yucatan Mexico
The whitefly Bemisia tabaci (Gennadius) has coevolved with intracellular endosymbiotic bacteria that help supplement their nutrient-poor diets with...
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Dramatic loss of microbial viability in bentonite exposed to heat and gamma radiation: implications for deep geological repository
Bentonite is an integral part of the engineered barrier system (EBS) in deep geological repositories (DGR) for nuclear waste, but its indigenous...
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Armored fish in cold polar waters: New information on the Arctic alligatorfish Aspidophoroides olrikii (Agonidae, Perciformes, Teleostei) from the Kara Sea (Siberian Arctic)
Data on the spatial and vertical distributions, temperature regime of habitat, size-age and, size-sex structure of Arctic alligatorfish Aspidophoroides...
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Development and validation of extraction and clean-up procedures for UPLC-MS/MS analysis of aflatoxins in spices
UPLC-MS/MS analytical conditions for the analysis of aflatoxins in spices were optimized and validated in this study. Liquid-liquid partition-based...
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Biodegradation of the cyanobacterial toxin anatoxin-a by a Bacillus subtilis strain isolated from a eutrophic lake in Saudi Arabia
Anatoxin-a (ATX-a) is a neurotoxin produced by some species of cyanobacteria. Due to its water solubility and stability in natural water, it could...
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Permafrost conditions influence the abundance, distribution, and leaf traits of two closely related dominant shrub species (Rhododendron subsect. Ledum) in interior Alaska
Permafrost considerably influences boreal forest ecosystems by constraining the niche space of woody plants. The influence of permafrost on...
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“Effect of Sunset Yellow on Testis: Molecular Evaluation, and Protective Role of Coenzyme Q10 in Male Sprague-Dawley Rats”
In recent years, Sunset Yellow (SY) has been widely used as a food additive, sparking debates about its potential toxicity. This research aims to...
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Neuroprotective Effects of Dehydroepiandrosterone and Hericium erinaceus in Scopolamine-induced Alzheimer’s Diseases-like Symptoms in Male Rats
BackgroundThe neuroprotective effects of Dehydroepiandrosterone (DHEA) and Hericium erinaceus (H . erinaceus ) mushroom extract against...
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The Impact of the VEGF/VEGFR2/PI3K/AKT Signaling Axis on the Proliferation and Migration Abilities of Human Dental Pulp Stem Cells
The potential therapeutic benefits of human dental pulp stem cells (HDPSCs) in dental regenerative medicine have been demonstrated. However, little...
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Individual and combined occurrences of the prevalent mycotoxins in commercial feline and canine food
Mycotoxins, such as aflatoxin B 1 (AFB 1 ), deoxynivalenol (DON), fumonisins (FBs), ochratoxin A (OTA), T-2 toxin (T-2), and zearalenone (ZEN), can...
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Tomatidine, a Steroidal Alkaloid, Synergizes with Cisplatin to Inhibit Cell Viability and Induce Cell Death Selectively on FLT3-ITD+ Acute Myeloid Leukemia Cells
BackgroundAcute Myeloid Leukemia (AML) is a hematological cancer that frequently presents with a range of side effects and drug resistance during...
