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Effects of voluntary and forced physical exercise on the retinal health of aging Wistar rats
Aging is accompanied by an increased prevalence of degenerative conditions, including those affecting ocular health, which significantly impact...
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Avidity maturation of humoral response following primary and booster doses of BNT162b2 mRNA vaccine among nursing home residents and healthcare workers
Infections, despite vaccination, can be clinically consequential for frail nursing home residents (NHR). Poor vaccine-induced antibody quality may...
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Self-rated health, epigenetic ageing, and long-term mortality in older Australians
Self-rated health (SRH) is a subjective indicator of overall health based on a single questionnaire item. Previous evidence found that it is a strong...
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Fmo induction as a tool to screen for pro-longevity drugs
Dietary restriction (DR) and hypoxia (low oxygen) extend lifespan in Caenorhabditis elegans through the induction of a convergent downstream...
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Ingestion of β-nicotinamide mononucleotide increased blood NAD levels, maintained walking speed, and improved sleep quality in older adults in a double-blind randomized, placebo-controlled study
The study evaluated how ingestion of nicotinamide mononucleotide (NMN) for 12 weeks by older adults affected blood nicotinamide adenine dinucleotide...
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Systemic metabolic benefits of 17α-estradiol are not exclusively mediated by ERα in glutamatergic or GABAergic neurons
17α-Estradiol (17αE2), a less-feminising enantiomer of 17β-estradiol, has been shown to prolong lifespan and improve metabolic health in a...
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Carotid-femoral pulse wave velocity score, an estimator of cognitive performance in the elderly: results from the Toledo Study for Healthy Aging
Ageing-related changes in the vascular wall influence the function of different organs; for this reason, we assessed how arterial stiffness measured...
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EEG entropy insights in the context of physiological aging and Alzheimer’s and Parkinson’s diseases: a comprehensive review
In recent decades, entropy measures have gained prominence in neuroscience due to the nonlinear behaviour exhibited by neural systems. This rationale...
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Optimizing cardiopulmonary rehabilitation duration for long COVID patients: an exercise physiology monitoring approach
The presence of prolonged symptoms after COVID infection worsens the workability and quality of life. 200 adults with long COVID syndrome were...
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Five years later, with double the demographic data, naked mole-rat mortality rates continue to defy Gompertzian laws by not increasing with age
The naked mole-rat ( Heterocephalus glaber ) is a mouse-sized rodent species, notable for its eusociality and long lifespan. Previously, we reported...
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Hepatic WDR23 proteostasis mediates insulin homeostasis by regulating insulin-degrading enzyme capacity
Maintaining insulin homeostasis is critical for cellular and organismal metabolism. In the liver, insulin is degraded by the activity of the...
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Everolimus alleviates CD4+ T cell inflammation by regulating autophagy and cellular redox homeostasis
Aging is associated with the onset and progression of multiple diseases, which limit health span. Chronic low-grade inflammation in the absence of...
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Quantification of age-related changes in the structure and mechanical function of skin with multiscale imaging
The mechanical properties of skin change during aging but the relationships between structure and mechanical function remain poorly understood....
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Quantification of healthspan in aging mice: introducing FAMY and GRAIL
The population around the world is graying, and as many of these individuals will spend years suffering from the burdens of age associated diseases,...
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A cocktail of rapamycin, acarbose, and phenylbutyrate prevents age-related cognitive decline in mice by targeting multiple aging pathways
Aging is a primary risk factor for cognitive impairment and exacerbates multiple biological processes in the brain, including but not limited to...
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Lifespan effects in male UM-HET3 mice treated with sodium thiosulfate, 16-hydroxyestriol, and late-start canagliflozin
Genetically heterogeneous UM-HET3 mice born in 2020 were used to test possible lifespan effects of alpha-ketoglutarate (AKG), 2,4-dinitrophenol...
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Amyloid β accelerates age-related proteome-wide protein insolubility
Loss of proteostasis is a highly conserved feature of aging across model organisms and results in the accumulation of insoluble protein aggregates....
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Clinical biomarker-based biological age predicts deaths in Brazilian adults: the ELSA-Brasil study
Biological age is a construct that seeks to evaluate the biological wear and tear process of the organism that cannot be observed by chronological...
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Geroscience: just another name or is there more to it?
The widespread use of the name ‘geroscience’ in the science of aging is sometimes met with a wary attitude by biogerontologists other than its...
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Intracellular cytokines in peritoneal leukocytes relate to lifespan in aging and long-lived female mice
Peritoneal immune cell function is a reliable indicator of aging and longevity in mice and inflammaging is associated with a shorter lifespan....
