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Boosting working memory in the elderly: driving prefrontal theta–gamma coupling via repeated neuromodulation
The escalating global burden of age-related neurodegenerative diseases and associated healthcare costs necessitates innovative interventions to...
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Maternal α-casein deficiency extends the lifespan of offspring and programmes their body composition
Early nutrition has significant effects on physiological outcomes during adult life. We have analysed the effect of maternal α-casein (CSN1S1)...
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The mouse Social Frailty Index (mSFI): a novel behavioral assessment for impaired social functioning in aging mice
Various approaches exist to quantify the aging process and estimate biological age on an individual level. Frailty indices based on an age-related...
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Association between dietary (poly)phenol intake and the ATHLOS Healthy Ageing Scale in the Polish arm of the HAPIEE study
Inverse association between (poly)phenol intake and age-related disorders has been demonstrated; however, little is known whether they affect...
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Phylloquinone improves endothelial function, inhibits cellular senescence, and vascular inflammation
Phylloquinon (PK) and menaquinones (MK) are both naturally occurring compounds belonging to vitamin K group. Present study aimed to comprehensively...
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Phosphodiesterase 9A inhibition improves aging-related increase in pulmonary vascular resistance in mice
As individuals age, there is a gradual decline in cardiopulmonary function, often accompanied by cardiac pump dysfunction leading to increased...
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Association between inflammatory markers, body composition and frailty in home-dwelling elderly: an 8-year follow-up study
Frailty has been linked to inflammation and changes in body composition, but the findings are inconsistent. To explore this, we used the Frailty...
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High rate of potentially inappropriate medication use in older people: a case–control study
Annually, 172 million fall events cause temporary or permanent impairment in older adults, and this number is increasing. Contributing factors that...
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Integrated renal and sympathetic mechanisms underlying the development of sex- and age-dependent hypertension and the salt sensitivity of blood pressure
Aging is a non-modifiable understudied risk factor for hypertension. We hypothesized that sympathetically mediated activation of renal sodium...
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Klotho enhances diastolic function in aged hearts through Sirt1-mediated pathways
Aging leads to a progressive decline in cardiac function, increasing the risk of heart failure with preserved ejection fraction (HFpEF). This study...
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Age-related decline in the expression of BRG1, ATM and ATR are partially reversed by dietary restriction in the livers of female mice
BRG1 (Brahma-related gene 1) is a member of the SWI/SNF (switch/sucrose nonfermentable) chromatin remodeling complex which utilizes the energy from...
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Proteomic analysis of lung responses to SARS-CoV-2 infection in aged non-human primates: clinical and research relevance
With devastating health and socioeconomic impact worldwide, much work is left to understand the Coronavirus Disease 2019 (COVID-19), with emphasis in...
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Low-molecular-weight heparin ameliorates intestinal barrier dysfunction in aged male rats via protection of tight junction proteins
The intestinal barrier weakens and chronic gut inflammation occurs in old age, causing age-related illnesses. Recent research shows that...
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Lifelong longitudinal assessment of the contribution of multi-fractal fluctuations to heart rate and heart rate variability in aging mice: role of the sinoatrial node and autonomic nervous system
Aging is a major risk factor for sinoatrial node (SAN) dysfunction, which can impair heart rate (HR) control and heart rate variability (HRV). HR and...
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A systematic review of diet and medication use among centenarians and near-centenarians worldwide
Centenarians represent a phenomenon of successful aging. This systematic review aimed to understand lifestyles and health practices, focusing on diet...
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Association of physical function with connectivity in the sensorimotor and dorsal attention networks: why examining specific components of physical function matters
Declining physical function with aging is associated with structural and functional brain network organization. Gaining a greater understanding of...
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Coffee consumption and cardiometabolic health: a comprehensive review of the evidence
This review provides a comprehensive synthesis of longitudinal observational and interventional studies on the cardiometabolic effects of coffee...
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The performance of metabolomics-based prediction scores for mortality in older patients with solid tumors
Prognostic information is needed to balance benefits and risks of cancer treatment in older patients. Metabolomics-based scores were previously...
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Aging is associated with sex-specific alteration in the expression of genes encoding for neuroestradiol synthesis and signaling proteins in the mouse trigeminal somatosensory input
Pain perception is influenced by sex and aging, with previous studies indicating the involvement of aromatase, the estradiol synthase enzyme, in...
