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BI-2865, a pan-KRAS inhibitor, reverses the P-glycoprotein induced multidrug resistance in vitro and in vivo
BackgroundMultidrug resistance (MDR) limits successful cancer chemotherapy. P-glycoprotein (P-gp), BCRP and MRP1 are the key triggers of MDR....
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KRAS-mutant non-small cell lung cancer (NSCLC) therapy based on tepotinib and omeprazole combination
BackgroundKRAS- mutant non-small cell lung cancer (NSCLC) shows a relatively low response rate to chemotherapy, immunotherapy and KRAS -G12C selective...
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Podoplanin depletion in tonsil-derived mesenchymal stem cells induces cellular senescence via regulation of the p16Ink4a/Rb pathway
BackgroundMesenchymal stem cells (MSCs) are widely used in the development of therapeutic tools in regenerative medicine. However, their quality...
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Motor skill learning modulates striatal extracellular vesicles’ content in a mouse model of Huntington’s disease
Huntington’s disease (HD) is a neurological disorder caused by a CAG expansion in the Huntingtin gene ( HTT ). HD pathology mostly affects striatal...
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Targeting mTOR signaling pathways in multiple myeloma: biology and implication for therapy
Multiple Myeloma (MM), a cancer of terminally differentiated plasma cells, is the second most prevalent hematological malignancy and is incurable due...
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Downregulation of the metalloproteinases ADAM10 or ADAM17 promotes osteoclast differentiation
Bone resorption is driven through osteoclast differentiation by macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor...
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Circadian patterns of growth factor receptor-dependent signaling and implications for carcinogenesis
Several different signaling pathways that regulate cell proliferation and differentiation are initiated by binding of ligands to cell-surface and...
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The IL-33-ST2 axis plays a vital role in endometriosis via promoting epithelial–mesenchymal transition by phosphorylating β-catenin
ObjectivesInterleukin 33 (IL-33) is a crucial inflammatory factor that functions as an alarm signal in endometriosis (EMs). Epithelial-mesenchymal...
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SacEXP32 sugarcane expansin gene expression increases cell size and improves biomass digestibility
Cellulose is the major renewable feedstock used in a variety of industrial processes. However, its native state, organizing itself in microfibrils...
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Homotherapy for heteropathy: therapeutic effect of Butein in NLRP3-driven diseases
BackgroundAberrant inflammatory responses drive the initiation and progression of various diseases, and hyperactivation of NLRP3 inflammasome is a...
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The FABD domain is critical for the oncogenicity of BCR/ABL in chronic myeloid leukaemia
BackgroundAbnormally expressed BCR/ABL protein serves as the basis for the development of chronic myeloid leukaemia (CML). The F-actin binding domain...
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Altered glia-neuron communication in Alzheimer’s Disease affects WNT, p53, and NFkB Signaling determined by snRNA-seq
BackgroundAlzheimer’s disease is the most common cause of dementia and is characterized by amyloid-β plaques, tau neurofibrillary tangles, and...
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Correlation and expression of OsMST1 gene with grain zinc and iron in brown and polished rice (Oryza sativa L.)
Zinc (Zn) and iron (Fe) are essential micronutrients involved in biochemical processes for growth and development of plants. OsMST1 ( monosaccharide...
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A novel role for KIFC1-MYH9 interaction in triple-negative breast cancer aggressiveness and racial disparity
African American (AA) women are twice as likely to develop triple-negative breast cancer (TNBC) as women of European descent. Additionally, AA women...
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Integrin αVβ1-activated PYK2 promotes the progression of non-small-cell lung cancer via the STAT3-VGF axis
BackgroundNon-small-cell lung cancer (NSCLC) accounts for 80–85% of all lung cancer and is the leading cause of cancer-related deaths globally....
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LKB1 biology: assessing the therapeutic relevancy of LKB1 inhibitors
Liver Kinase B1 (LKB1), encoded by Serine-Threonine Kinase 11 ( STK11 ), is a master kinase that regulates cell migration, polarity, proliferation, and...
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Advances in the understanding of heat shock proteins and their functions in reducing abiotic stress in plants
Abiotic stresses such as high temperature, excessive cold, flood, salinity, and drought disturb the normal growth and production which aggravate...
