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Fetal liver CD34+ contain human immune and endothelial progenitors and mediate solid tumor rejection in NOG mice
BackgroundTransplantation of CD34 + hematopoietic stem and progenitor cells (HSPC) into immunodeficient mice is an established method to generate...
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The impact of hypoxia preconditioning on mesenchymal stem cells performance in hypertensive kidney disease
BackgroundAutologous mesenchymal stem cells (MSCs) have emerged as a therapeutic option for many diseases. Hypertensive kidney disease (HKD) might...
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Mesenchymal stem cell therapy for therapy refractory complex Crohn’s perianal fistulas: a case series
BackgroundMesenchymal stem cell treatment (MST) has emerged as a new therapeutic strategy for Crohn’s perianal fistulas. It has been demonstrated...
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Human platelet lysate-cultured adipose-derived stem cell sheets promote angiogenesis and accelerate wound healing via CCL5 modulation
BackgroundA rising population faces challenges with healing-impaired cutaneous wounds, often leading to physical disabilities. Adipose-derived stem...
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Motion-Accommodating Dual-Layer Hydrogel Dressing to Deliver Adipose-Derived Stem Cells to Wounds
Background:Current dressing materials cannot secure a cell survival-promoting wound environment for stem cell delivery due to insufficient...
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Enzymes in the bioconversion of food waste into valuable bioproducts: A circular economy perspective
The escalating global challenges of food security, waste management, and environmental sustainability have necessitated the application of novel...
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Non-coding RNAs Function in Periodontal Ligament Stem Cells
Non-coding RNA has many types which has rich functions and plays an important role in the study of basic molecular mechanisms. Many non-coding RNA...
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Evaluation of brown midrib (bmr) sorghum stover as potential renewable biomass feedstock for poly(3-hydroxybutyrate) production employing Paraburkholderia Sacchari and Cupriavidus necator
The aim of this work was to evaluate the use of stover from brown midrib ( bmr ) grain sorghum to produce polyhydroxyalkanoates (PHAs). These mutants...
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Improving Granulosa Cell Function in Premature Ovarian Failure with Umbilical Cord Mesenchymal Stromal Cell Exosome-Derived hsa_circ_0002021
Background:The therapeutic potential of exosomes from human umbilical cord mesenchymal stem cells (HUMSCs-Exo) for delivering specific circular RNAs...
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Single high-dose intravenous injection of Wharton’s jelly-derived mesenchymal stem cell exerts protective effects in a rat model of metabolic syndrome
BackgroundMetabolic syndrome (MetS) is a significant epidemiological problem worldwide. It is a pre-morbid, chronic and low-grade inflammatory...
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Role of Stem Cells in the Pathogenesis and Malignant Transformation of Oral Submucous Fibrosis
BackgroundPathogenesis and malignant potential of Oral submucous fibrosis(OSMF) have always been a topic of interest among the researchers. Despite...
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In Vitro Cell Surface Marker Expression on Mesenchymal Stem Cell Cultures does not Reflect Their Ex Vivo Phenotype
Cell surface marker expression is one of the criteria for defining human mesenchymal stem or stromal cells (MSC) in vitro. However, it is unclear if...
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Human Amniotic Epithelial Stem Cells Alleviate Autoimmune Premature Ovarian Insufficiency in Mice by Targeting Granulosa Cells via AKT/ERK Pathways
Autoimmune factors play an important role in premature ovarian insufficiency (POI). Human amniotic epithelial stem cells (hAESCs) have recently shown...
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Efficacy and Safety Evaluation of Tacrolimus-Eluting Stent in a Porcine Coronary Artery Model
Background:A drug-eluting stent (DES) is a highly beneficial medical device used to widen or unblock narrowed blood vessels. However, the drugs...
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Extremophiles and their enzymatic diversity and biotechnological potential
Extremophiles and their enzymes are explored in this review article, which highlights the peculiar adaptations that these organisms have developed to...
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Enhanced osteochondral repair by leukocyte-depleted platelet-rich plasma in combination with adipose-derived mesenchymal stromal cells encapsulated in a three-dimensional photocrosslinked injectable hydrogel in a rabbit model
IntroductionIntra-articular injection of adipose-derived mesenchymal stromal cells (ASCs) and/or platelet-rich plasma (PRP) have been reported to...
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Recycling spent animal cell culture media using the thermally resistant microalga Chlorella sorokiniana
Cell culture media is a significant contributor to the high cost of bioprocesses. This study explored the potential of algae to re-condition spent...
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Harnessing three-dimensional porous chitosan microsphere embedded with adipose-derived stem cells to promote nerve regeneration
BackgroundNerve guide conduits are a promising strategy for reconstructing peripheral nerve defects. Improving the survival rate of seed cells in...
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Evaluation of Bi-layer Silk Fibroin Grafts for Inlay Vaginoplasty in a Rat Model
Background:Autologous tissues derived from bowel, buccal mucosa and skin are primarily used to repair or replace diseased vaginal segments as well as...
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Comparison of allo-SCT, auto-SCT and chemotherapy for the treatment of patients with low- or intermediate-risk acute myeloid leukemia: a network meta-analysis
BackgroundThe therapeutic status of allogeneic stem cell transplantation (allo-SCT) as a post-remission treatment for patients with high-risk acute...