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Platelet-Rich Plasma-Embedded Porous Polycaprolactone Film with a Large Surface Area for Effective Hemostasis
Background:Uncontrollable and widespread bleeding caused by surgery or sudden accidents can lead to death if not treated with appropriate hemostasis....
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Standardized generation of human iPSC-derived hematopoietic organoids and macrophages utilizing a benchtop bioreactor platform under fully defined conditions
BackgroundThere is a significant demand for intermediate-scale bioreactors in academic and industrial institutions to produce cells for various...
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Regenerative medicine in the treatment of specific dermatologic disorders: a systematic review of randomized controlled clinical trials
Aims and objectivesThe aim of this study is to systematically review randomized controlled clinical trials (RCTs) studying various types of...
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Insights into the role of mesenchymal stem cells in cutaneous medical aesthetics: from basics to clinics
With the development of the economy and the increasing prevalence of skin problems, cutaneous medical aesthetics are gaining more and more attention....
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Mechanical stimulation-induced purinome priming fosters osteogenic differentiation and osteointegration of mesenchymal stem cells from the bone marrow of post-menopausal women
BackgroundMechanical stimulation (MS) significantly increases the release of adenine and uracil nucleotides from bone marrow-derived mesenchymal stem...
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LncRNA SNHG1 enhances cartilage regeneration by modulating chondrogenic differentiation and angiogenesis potentials of JBMMSCs via mitochondrial function regulation
BackgroundCartilage is a kind of avascular tissue, and it is difficult to repair itself when it is damaged. In this study, we investigated the...
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Extracellular matrices of stromal cell subtypes regulate phenotype and contribute to the stromal microenvironment in vivo
BackgroundBone marrow stromal cells (BMSCs) are highly heterogeneous, which may reflect their diverse biological functions, including tissue...
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Stem cell-based therapy for fibrotic diseases: mechanisms and pathways
Fibrosis is a pathological process, that could result in permanent scarring and impairment of the physiological function of the affected organ; this...
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Reprogramming of 3D genome structure underlying HSPC development in zebrafish
BackgroundDevelopment of hematopoietic stem and progenitor cells (HSPC) is a multi-staged complex process that conserved between zebrafish and...
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CAR-T cell-derived exosomes: a new perspective for cancer therapy
Chimeric antigen receptor (CAR)-T cell adoptive immunotherapy is a promising cancer treatment that uses genetically engineered T cells to attack...
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Sources and applications of endothelial seed cells: a review
Endothelial cells (ECs) are widely used as donor cells in tissue engineering, organoid vascularization, and in vitro microvascular model development....
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Combination of induced pluripotent stem cell-derived motor neuron progenitor cells with irradiated brain-derived neurotrophic factor over-expressing engineered mesenchymal stem cells enhanced restoration of axonal regeneration in a chronic spinal cord injury rat model
BackgroundSpinal cord injury (SCI) is a disease that causes permanent impairment of motor, sensory, and autonomic nervous system functions. Stem cell...
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Generation and Characterization of Induced Pluripotent Stem Cells Carrying An ASXL1 Mutation
Additional sex combs-like 1 ( ASXL1 ) is an epigenetic modulator frequently mutated in myeloid malignancies, generally associated with poor prognosis....
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Enhancing Proliferation of Stem Cells from Human Exfoliated Deciduous Teeth (SHED) through hTERT Expression while Preserving Stemness and Multipotency
BackgroundStem cells from human exfoliated deciduous teeth (SHED) hold promise in regenerative medicine owing to their multipotent capabilities...
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The Impact of Umbilical Cord Mesenchymal Stem Cells on Motor Function in Children with Cerebral Palsy: Results of a Real-world, Compassionate use Study
The aim of this study was to analyze the impact of human umbilical cord-derived MSCs (hUC-MSCs) on motor function in children with cerebral palsy...
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Implantation of Culture-Expanded Bone Marrow Derived Mesenchymal Stromal Cells for Treatment of Osteonecrosis of the Femoral Head
Background:Although core decompression (CD) with stem cell for the treatment of osteonecrosis of the femoral head (ONFH) showed promising results in...
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Multifunctional Microneedle Patch with Diphlorethohydroxycarmalol for Potential Wound Dressing
BACKGROUND: Treatment of skin wounds with diverse pathological characteristics presents significant challenges due to the limited specific and...
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Dose-response relationship of MSCs as living Bio-drugs in HFrEF patients: a systematic review and meta-analysis of RCTs
BackgroundMesenchymal stem cells (MSCs) have emerged as living biodrugs for myocardial repair and regeneration. Recent randomized controlled trials...
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Endogenous stem cell mobilization and localized immunosuppression synergistically ameliorate DSS-induced Colitis in mice
BackgroundStem cell therapy is a promising alternative for inflammatory diseases and tissue injury treatment. Exogenous delivery of mesenchymal stem...
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Inhibition and reversal of a TGF-β1 induced myofibroblast phenotype by adipose tissue-derived paracrine factors
BackgroundHypertrophic scarring results from myofibroblast differentiation and persistence during wound healing. Currently no effective treatment for...
