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Effects of Staphylococcus aureus on stem cells and potential targeted treatment of inflammatory disorders
Due to the advanced studies on stem cells in developmental biology, the roles of stem cells in the body and their phenotypes in related diseases have...
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Enzymes in the production of cultivated meat products
Enzymes play a pivotal role in meat processing and maturation, starting with endogenous enzymes that catalyse a partial proteolysis in natural meat...
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Ameliorating and refining islet organoids to illuminate treatment and pathogenesis of diabetes mellitus
Diabetes mellitus, a significant global public health challenge, severely impacts human health worldwide. The organoid, an innovative in vitro...
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Desktop-Stereolithography 3D Printing of a Decellularized Extracellular Matrix/Mesenchymal Stem Cell Exosome Bioink for Vaginal Reconstruction
Background3D-printing is widely used in regenerative medicine and is expected to achieve vaginal morphological restoration and true functional...
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Culturing Conditions Dictate the Composition and Pathways Enrichment of Human and Rat Perirenal Adipose-Derived Stromal Cells’ Secretomes
Understanding the impact of various culturing strategies on the secretome composition of adipose-derived stromal cells (ASC) enhances their...
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iPSCs chondrogenic differentiation for personalized regenerative medicine: a literature review
Cartilage, an important connective tissue, provides structural support to other body tissues, and serves as a cushion against impacts throughout the...
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Bioorthogonal non-canonical amino acid tagging to track transplanted human induced pluripotent stem cell-specific proteome
BackgroundHuman induced pluripotent stem cells (hiPSCs) and their differentiated cell types have a great potential for tissue repair and...
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Identifying miRNA Signatures Associated with Pancreatic Islet Dysfunction in a FOXA2-Deficient iPSC Model
The pathogenesis of diabetes involves complex changes in the expression profiles of mRNA and non-coding RNAs within pancreatic islet cells. Recent...
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Algal biorefinery: focus on cosmeceuticals
Amidst the ever-evolving landscape of cosmetics, algae and their derived products have captured substantial worldwide interest, heralding a new era...
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Hypoxia Promotes the Stemness of Mesangiogenic Progenitor Cells and Prevents Osteogenic but not Angiogenic Differentiation
The stem cell niche in the bone marrow is a hypoxic environment, where the low oxygen tension preserves the pluripotency of stem cells. We have...
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16S amplicon sequencing of the gastrointestinal microbiota of Cirrhinus reba and isolation of an autochthonous probiotic using culture based approaches
The microbiome in the gastrointestinal tract (GIT) of fish influences host health in both beneficial and detrimental ways and understanding the gut...
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Unveiling the potential of systems biology in biotechnology and biomedical research
“In silico organisms” are computational genome-scale metabolic models used in systems and synthetic biology developed by constraint-based metabolic...
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Adipose-Derived Mesenchymal Stem Cells and Their Derived Epidermal Progenitor Cells Conditioned Media Ameliorate Skin Aging in Rats
BACKGROUND: Skin alterations are among the most prominent signs of aging, and they arise from both intrinsic and extrinsic factors that interact and...
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Transplantation of Neural Progenitor Cells Derived from Stem Cells from Apical Papilla Through Small-Molecule Induction in a Rat Model of Sciatic Nerve Injury
Background:Stem cell-based transplantation therapy holds promise for peripheral nerve injury treatment, but adult availability is limited. A cell...
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Restoration of functional endometrium in an intrauterine adhesion rat model with endometrial stromal cells transplantation
BackgroundIntrauterine adhesion (IUA) as a prevalent gynecological disease is developed from infection or trauma. However, therapeutic strategies to...
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UBQLN1 links proteostasis and mitochondria function to telomere maintenance in human embryonic stem cells
BackgroundTelomeres consist of repetitive DNA sequences at the chromosome ends to protect chromosomal stability, and primarily maintained by...
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Improvement of multilineage hematopoiesis in hematopoietic stem cell-transferred c-kit mutant NOG-EXL humanized mice
Human hematopoietic stem cell (HSC)-transferred humanized mice are valuable models for exploring human hematology and immunology. However, sufficient...
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Osteochondral organoids: current advances, applications, and upcoming challenges
In the realm of studying joint-related diseases, there is a continuous quest for more accurate and representative models. Recently, regenerative...
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Dual inhibition of P38 MAPK and JNK pathways preserves stemness markers and alleviates premature activation of muscle stem cells during isolation
BackgroundAdult skeletal muscle contains resident muscle stem cells (MuSC) with high myogenic and engraftment potentials, making them suitable for...
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Retinoic acid modulation guides human-induced pluripotent stem cell differentiation towards left or right ventricle-like cardiomyocytes
BackgroundCardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSCs) by traditional methods are a mix of atrial and ventricular...
