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DART.2: bidirectional synaptic pharmacology with thousandfold cellular specificity
Precision pharmacology aims to manipulate specific cellular interactions within complex tissues. In this pursuit, we introduce DART.2 (drug acutely...
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Recovering true FRET efficiencies from smFRET investigations requires triplet state mitigation
Single-molecule fluorescence resonance energy transfer (smFRET) methods employed to quantify time-dependent compositional and conformational changes...
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Biophysical Reviews: a call for nominations to the 2025 Michèle Auger Award
This editorial describes an open call for nominations to the 2025 Michèle Auger Award for Young Scientists’ Independent Research, the single award...
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Phenoty** grapevine resistance to downy mildew: deep learning as a promising tool to assess sporulation and necrosis
BackgroundDowny mildew is a plant disease that affects all cultivated European grapevine varieties. The disease is caused by the oomycete Plasmopara...
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CellRank 2: unified fate map** in multiview single-cell data
Single-cell RNA sequencing allows us to model cellular state dynamics and fate decisions using expression similarity or RNA velocity to reconstruct...
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Capturing acyl–enzyme intermediates with genetically encoded 2,3-diaminopropionic acid for hydrolase substrate identification
Catalytic mechanism-based, light-activated traps have recently been developed to identify the substrates of cysteine or serine hydrolases. These...
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Data-driven regularization lowers the size barrier of cryo-EM structure determination
Macromolecular structure determination by electron cryo-microscopy (cryo-EM) is limited by the alignment of noisy images of individual particles....
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A pin-based probe for electronic moisture meters to determine moisture content in a single wheat kernel
BackgroundOptimum moisture in straw and grain at maturity is important for timely harvesting of wheat. Grain harvested at the right time has reduced...
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Exploring UAS-lidar as a sampling tool for satellite-based AGB estimations in the Miombo woodland of Zambia
To date, only a limited number of studies have utilized remote sensing imagery to estimate aboveground biomass (AGB) in the Miombo ecoregion using...
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Hyperspectral imaging for quantifying Magnaporthe oryzae sporulation on rice genotypes
BackgroundPrecise evaluation of fungal conidia production may facilitate studies on resistance mechanisms and plant breeding for disease resistance....
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Interactions of coinage metal nanoclusters with low-molecular-weight biocompounds
Nowadays, coinage metal nanoclusters (NCs) are largely presented in diagnostics, bioimaging, and biocatalysis due to their high biocompatibility,...