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Biosynthesis and function of 1-methyladenosine in transfer RNA
Determining the function of single nucleotide modifications in tRNA has been elusive because so many tRNA modification enzymes are not essential for...
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Transfer RNA modifications and modifying enzymes in Saccharomyces cerevisiae
Transfer RNAs are adaptor molecules, which decode mRNA into protein and, thereby, play a central role in gene expression. During the maturation of a...
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The biosynthesis and functional roles of methylated nucleosides in eukaryotic mRNA
Modified nucleosides are present in mRNA of all eukaryotes, albeit at much lower levels than in other RNA moieties such as rRNA, tRNA, and snRNA....
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Adenosine to inosine RNA editing in animal cells
Major advances in the understanding of adenosine deaminases acting on RNA (ADARs) have come from the generation of ADAR mutant animals. In mice,...
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Conserved ribosomal RNA modification and their putative roles in ribosome biogenesis and translation
rRNA maturation requires extensive covalent modifications of riboses and bases. These modifications concern exclusively the most conserved regions of...
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Biosynthesis and function of tRNA wobble modifications
Post-transcriptional modifications at the first (wobble) position of the tRNA anticodon participate in the precise decoding of the genetic code that...
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Role of the 5’-cap in the biogenesis of spliceosomal snRNPs
The biogenesis of spliceosomal UsnRNPs in higher eukaryotes involves a nucleocytoplasmic shuttling cycle. After transcription and processing in the...
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Mechanisms and functions of RNA-guided RNA modification
RNA-guided 2’-O-methylations and pseudouridylations occur in several different types of RNAs and in a wide range of organisms. Hundreds of the RNAs...
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Translational Recoding and RNA Modifications
During protein synthesis, codons in mRNA are translated sequentially in frame on the ribosome following strict decoding rules. This process is...
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Modification and editing of RNA: historical overview and important facts to remember
RNA plays a central role in many cellular processes and several peculiarities of RNAs are probably relics of an ancient primordial RNA World. To...
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Role of a conserved pseudouridine in U2 snRNA on the structural and electrostatic features of the spliceosomal pre-mRNA branch site
A pseudouridine (ψ) residue in a phylogenetically conserved position of U2 snRNA that pairs with the intron to form the pre-mRNA branch site helix of...
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Um34 in selenocysteine tRNA is required for the expression of stress-related selenoproteins in mammals
Selenium is an essential micronutrient in the diet of mammals and has many health benefits. Selenium-containing proteins are responsible for most, if...
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Mammalian C to U editing
The sequencing of genomes from higher organisms demonstrated that the number and complexity of expressed mRNA sequences and proteins exceeds the...
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Nucleotide methylations in rRNA that confer resistance to ribosome-targeting antibiotics
Methylation of rRNA nucleotides is an effective means of conferring resistance to antibiotics that target the bacterial ribosome. This type of...
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Editing and modification in trypanosomatids: the resha** of non-coding RNAs
Trypanosomatids include a number of protozoan parasites that infect over 27 million people worldwide. Besides their medical importance, these...
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Transfer RNA modifications and DNA editing in HIV-1 reverse transcription
Reverse transcription is a central step in HIV-1 replication that represents a typical case of interplay between viral and cellular factors. HIV-1...
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Comparative proteomics in tall fescue to reveal underlying mechanisms for improving Photosystem II thermotolerance during heat stress memory
BackgroundThe escalating impacts of global warming intensify the detrimental effects of heat stress on crop growth and yield. Among the earliest and...
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LAFeBS, alive, kicking, and growing: the story continues…
This Commentary describes a call for contributions to an upcoming Special Issue (SI) of Biophysical Reviews on the Latin American Federation of...
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Population structure and selection signal analysis of indigenous sheep from the southern edge of the Taklamakan Desert
Analyzing the genetic diversity and selection characteristics of sheep (Ovis aries) holds significant value in understanding their environmental...
