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Carbonyl Sulfide as a Prebiotic Activation Agent for Stereo- and Sequence-Selective, Amyloid-Templated Peptide Elongation
Prebiotic chemical replication is a commonly assumed precursor to and prerequisite for life and as such is the one of the goals of our research. We...
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Imidazolium-Catalyzed Synthesis of an Imidazolium Catalyst
The chemistry of imidazolium-catalyzed imidazolium synthesis was studied as part of an effort to develop a plausible prebiotic synthesis of a small...
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The Oligomerization of Glucose Under Plausible Prebiotic Conditions
The prebiotic origin of polysaccharides, the largest class of biopolymers by mass in extant biology, has seldom been investigated experimentally....
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Spontaneous Resolution and Super-coiling in Xerogels of the Products of Photo-Induced Formose Reaction
This work addresses the supramolecular self-organization in the xerogels of formose reaction products. The UV-induced formose reaction was held in...
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Synthesis of Nucleic Acid Bases by Metal Ferrite Nanoparticles from a Single Carbon Atom Precursor Molecule: Formamide
The synthesis of prebiotic molecules from simple precursors is believed to be a crucial scheme in order to study the origin of life processes. The...
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Hidden Concepts in the History and Philosophy of Origins-of-Life Studies: a Workshop Report
In this review, we describe some of the central philosophical issues facing origins-of-life research and provide a targeted history of the...
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Interactions of Amino Acids and Aminoxazole Derivatives: Cocrystal Formation and Prebiotic Implications Enabled by Computational Analysis
In line with the postulated intermediacy of aminoxazoles derived from small sugars toward the direct assembly of nucleoside precursors, we show here...
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Theoretical Study of Possible Reaction Mechanisms for the Formation of Carbodiimide in the Interstellar Medium (ISM) and Polarizabilities of Carbodiimide
The Structure of carbodiimide has been studied by using quantum chemical methods. Carbodiimide (HNCNH) has been detected towards Sagittarius B2 (N)...
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Towards a General Definition of Life
A new definition of life is proposed and discussed in the present article. It is formulated by modifying and extending NASA’s working definition of...
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The Limited Roles of Autocatalysis and Enantiomeric Cross-Inhibition in Achieving Homochirality in Dilute Systems
To understand the effects of fluctuations on achieving homochirality, we employ a Monte-Carlo method where autocatalysis and enantiomeric...
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Pyrite and Organic Compounds Coexisting in Intrusive Mafic Xenoliths (Hyblean Plateau, Sicily): Implications for Subsurface Abiogenesis
Pyrite and organic matter closely coexist in some hydrothermally-altered gabbroic xenoliths from the Hyblean Plateau, Sicily. The representative...
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The RNA i-Motif in the Primordial RNA World
The primordial RNA world is a hypothetical era prior to the appearance of protein and DNA, when RNA molecules were the sole building blocks for early...
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The Origin of tRNA Deduced from Pseudomonas aeruginosa 5′ Anticodon-Stem Sequence
The riddle of the origin of life is unsolved as yet. One of the best ways to solve the riddle would be to find a vestige of the first life from...
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Prebiotic Syntheses Under Shock in the Water – Formamide – Potassium Bicarbonate – Sodium Hydroxide System
Syntheses under shock in nitrogen bubbled samples of the water – formamide – bicarbonate – sodium hydroxide system at pH 8.63, 9.46 and 10.44 were...
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A Possible Prebiotic Ancestry of Porphyrin-Type Protein Cofactors
In previous experiments that simulated conditions on primordial volcanic islands, we demonstrated the abiotic formation of hydrophobic porphyrins....
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Methanogenesis on Early Stages of Life: Ancient but Not Primordial
Of the six known autotrophic pathways, the Wood-Ljungdahl pathway (WL) is the only one present in both the acetate producing Bacteria (homoacetogens)...
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The Birthplace of Proto-Life: Role of Secondary Minerals in Forming Metallo-Proteins through Water-Rock Interaction of Hadean Rocks
The surface of Hadean Earth was mainly covered with three types of rocks—komatiite, KREEP basalt and anorthosite—which were remarkably different from...
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Chiral Recognition in Cold Gas-Phase Cluster Ions of Carbohydrates and Tryptophan Probed by Photodissociation
Chiral recognition between tryptophan (Trp) and carbohydrates such as d -glucose ( d -Glc), methyl-α- d -glucoside ( d -glucoside), d -maltose, and d -cellobio...
