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A Cofactor-Based Mechanism for the Origin of the Genetic Code
The origin of the genetic code is probably the central problem of the studies on the origin of life. The key question to answer is the molecular...
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Symmetry Breaking by Consecutive Amplification: Efficient Paths to Homochirality
To understand chiral symmetry breaking on the molecular level, we developed a method to efficiently investigate reaction kinetics of single...
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Biological Homochirality and the Search for Extraterrestrial Biosignatures
Most amino acids and sugar molecules occur in mirror, or chiral, images of each other, knowns as enantiomers. However, life on Earth is mostly...
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Asymmetric Autocatalysis as an Efficient Link Between the Origin of Homochirality and Highly Enantioenriched Compounds
Biological homochirality of essential components such as L -amino acids and D -sugars is prerequisite for the emergence, evolution and the maintenance...
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On the Origin of Sugar Handedness: Facts, Hypotheses and Missing Links-A Review
By paraphrasing one of Kipling’s most amazing short stories ( How the Leopard Got His Spots ), this article could be entitled “How Sugars Became...
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Competitive interaction of Mn(II) and Fe(II) cations with the high-affinity Mn-binding site of the photosystem II: evolutionary aspect
The evolutionary origin of the oxygen-evolving complex (OEC) in the photosystem II (PSII) is still unclear, as is the nature of electron source for...
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Frontiers in Prebiotic Chemistry and Early Earth Environments
The Prebiotic Chemistry and Early Earth Environments (PCE 3 ) Consortium is a community of researchers seeking to understand the origins of life on...
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Spontaneous Emergence of Transient Chirality in Closed, Reversible Frank-like Deterministic Models
To explore abiotic theories related to the origin of biomolecular homochirality, we analyze two entirely reversible kinetic models composed of an...
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Molecular Self-Assembly as a Trigger of Life Origin and Development
The origin and reason for the homochirality of living cells go with the problem of a relatively narrow spectrum of the actual biological monomers...
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Gaia as Solaris: An Alternative Default Evolutionary Trajectory
Now that we know that Earth-like planets are ubiquitous in the universe, as well as that most of them are much older than the Earth, it is justified...
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The Effect of Goethites on the Polymerization of Glycine and Alanine Under Prebiotic Chemistry Conditions
After pre concentration of monomers, polymerization is the second most important step for molecular evolution. The formation of peptides is an...
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Ribozyme Mutagenic Evolution: Mechanisms of Survival
Primeval populations replicating at high error rates required a mechanism to overcome the accumulation of mutations and information deterioration....
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Computational Study of the Stability of Natural Amino Acid isomers
The secular debate on the origin of life on our planet represents one of the open challenges for the scientific community. In this endeavour,...
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Does Stochasticity Favour Complexity in a Prebiotic Peptide-Micelle System?
A primordial environment that hosted complex pre- or proto-biochemical activity would have been subject to random fluctuations. A relevant question...
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The Codon Usage in the Minimal Natural Cell
A statistical analysis of the variation in contents with the size of the current known smallest genomes, N. deltocephalinicola, C. ruddii, N. equitans ...
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How the Geomagnetic Field Influences Life on Earth – An Integrated Approach to Geomagnetobiology
Earth is one of the inner planets of the Solar System, but – unlike the others – it has an oxidising atmosphere, relatively stable temperature, and a...
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Plausible Emergence and Self Assembly of a Primitive Phospholipid from Reduced Phosphorus on the Primordial Earth
How life arose on the primitive Earth is one of the biggest questions in science. Biomolecular emergence scenarios have proliferated in the...
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Quadruplex World
The RNA world hypothesis relies on the double-helix complementarity principle for both replication and catalytic activity of RNA. However, the de...
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Possible Ancestral Functions of the Genetic and RNA Operational Precodes and the Origin of the Genetic System
The origin of genetic systems is the central problem in the study of the origin of life for which various explanatory hypotheses have been presented....
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Role of the Interchangeable Cations on the Sorption of Fumaric and Succinic Acids on Montmorillonite and its Relevance in Prebiotic Chemistry
It has been proposed that clays could have served as key factors in promoting the increase in complexity of organic matter in primitive terrestrial...
