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Comparative genomics and gene finding in fungi
In the spring of 2005, we had access to 18 fully sequenced fungal genomes, and more are coming rapidly. New approaches and methods are being...
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10 Sphingosine-1-phosphate metabolism in mammalian cell signalling
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite implicated in the regulation of vital biological processes. Ample evidence...
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8 Biosynthesis and compartmentation of triacylglycerol in higher plants
The biosynthesis of storage lipids (triacylglycerols) in higher plants is now known to occur via a number of different routes. These include the...
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Introduction: Lipids: cellular glue...or are they more than that?
Some 40 years ago, there was a rumor in the research community that lipids are the stuff you have to throw away before starting biochemical...
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Lager brewing yeast
Lager brewing yeast is a group of closely related strains of Saccharomyces pastorianus/S. carlsbergensis used for lager beer production all over the...
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9 Mechanisms and mediators of neutral lipid biosynthesis in eukaryotic cells
The reactions leading to the biosynthesis of neutral lipids are excellent targets for therapeutic intervention in several disease states including...
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3 Biogenesis and cellular dynamics of glycerophospholipids in the yeast Saccharomyces cerevisiae
In the yeast Saccharomyces cerevisiae, as in other eukaryotes, glycerophospholipids are important cellular components required for growth and cell...
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4 Defects in cholesterol biosynthesis
Defects in eight different enzymes of cholesterol biosynthesis that result in serious clinical consequences have been identified. Most of these were...
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Duplication of genes and genomes in yeasts
The molecular evolution of the group of yeasts closely related to Saccharomyces cerevisiae has been profoundly affected by an ancient polyploidy...
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Sources and Fate of Organic Contaminants in the Marine Environment
The sources, levels, and fate of organic contaminants of major concern in the marine environment are reviewed. Spatial distributions among the...
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Lipid Markers for Marine Organic Matter
An astonishing variety of different lipids have been found in marine sediments and the water column attesting to the diversity of biosynthetic...
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Pigment Markers for Phytoplankton Production
Chlorophylls and carotenoids are commonly used as quantitative biomarkers for the composition and biomass of marine phytoplankton. This chapter...
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Isotopic Tracers of the Marine Nitrogen Cycle: Present and Past
The oceanic nitrogen cycle consists of a web of microbially mediated transformations driven in part by the large range in possible nitrogen...
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Employing protein size in the functional analysis of orthologous proteins, as illustrated with the yeast HOG pathway
Comparative genomics has provided us with a new handle on the interpretation of protein sequences. The sequencing of numerous fungal genomes has...
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Early oxidative stress and DNA damage in Aβ-burdened hippocampal neurons in an Alzheimer’s-like transgenic rat model
Oxidative stress is a key contributor to AD pathology. However, the earliest role of pre-plaque neuronal oxidative stress, remains elusive. Using...
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A versatile functional interaction between electrically silent KV subunits and KV7 potassium channels
Voltage-gated K + (K V ) channels govern K + ion flux across cell membranes in response to changes in membrane potential. They are formed by the assembly...
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Genomic characterization and virulence gene profiling of Erysipelothrix rhusiopathiae isolated from widespread muskox mortalities in the Canadian Arctic Archipelago
BackgroundMuskoxen are important ecosystem components and provide food, economic opportunities, and cultural well-being for Indigenous communities in...
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Identification of volatile metabolites produced from levodopa metabolism by different bacteria strains of the gut microbiome
Interspecies pathways in the gut microbiome have been shown to metabolize levodopa, the primary treatment for Parkinson’s disease, and reduce its...
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C4-like Sesuvium sesuvioides (Aizoaceae) exhibits CAM in cotyledons and putative C4-like + CAM metabolism in adult leaves as revealed by transcriptome analysis
BackgroundThe co-occurrence of C 4 and CAM photosynthesis in a single species seems to be unusual and rare. This is likely due to the difficulty in...
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Increasing the efficiency of CRISPR/Cas9-mediated genome editing in the citrus postharvest pathogen Penicillium digitatum
BackgroundPenicillium digitatum is a fungal plant pathogen that causes the green mold disease in harvested citrus fruits. Due to its economical...
