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Systems biology of apoptosis
New approaches are required for the mathematical modelling and system identification of complex signal transduction networks, which are characterized...
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Scientific and technical challenges for systems biology
Systems biology is an emergent discipline, yet can be rooted back almost a century when pioneering thoughts on system-oriented views were discussed....
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Systems Biology: necessary developments and trends
At the end of this definition of Systems Biology through exampling, we discuss ambitions, goals, and challenges relating to this new discipline. We...
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Transcriptome analysis in abiotic stress conditions in higher plants
Drought, high salinity, and low temperature are major environmental factors that limit plant productivity. Plants respond and adapt to these stresses...
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Signal transduction in plant cold acclimation
Temperate plants respond to low temperature by activating a cold acclimation program leading to enhanced tolerance to freezing temperatures. This...
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Plant salt tolerance
Soil salinity adversely affects crop productivity and quality. The success of breeding programs aimed at salinity tolerant crop varieties is limited...
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Plant responses to heat stress
The heat stress response is characterized by inhibition of normal transcription and translation, higher expression of heat shock proteins (hsps) and...
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Sensors of abiotic stress in Synechocystis
Systematic mutagenesis of histidine kinases in combination with DNA microarray technology has allowed us to identify sensors for cold, hyperosmotic...
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Abscisic acid signalling
Signalling of abscisic acid (ABA) in plants is characterized by an amazing number of secondary messengers that are part of the pathway or modulate...
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From isolation to integration, a systems biology approach for building the Silicon Cell
In the last decade, the field now commonly referred to as systems biology has developed rapidly. With the sequencing of whole genomes and the...
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Modelling signalling pathways – a yeast approach
MAP kinase pathways are conserved signalling systems in eukaryotes that control stress responses, cell growth, and proliferation, as well as...
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Metabolic flux analysis: A key methodology for systems biology of metabolism
Genome-wide analyses of mRNA, protein, or metabolite complements of biological systems produce unprecedented data sets. In contrast to such cellular...
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Mechanistic and modular approaches to modeling and inference of cellular regulatory networks
In this chapter we wish to present a vision of systems biology as a discipline that generates new insight and knowledge with quantitative and...
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Mathematical modelling of the Wnt-pathway
A kinetic model of the Wnt-signal transduction pathway is presented which includes the main molecular components of this system. It is based on a set...
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Systems Biology: Did we know it all along?
It is often suggested that Systems Biology is nothing new, or that it is irrelevant. Its central paradigm, i.e. that much of biological function...
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Systems biology of the yeast cell cycle engine
One goal of systems biology is to obtain an integrated understanding of the physiological properties of cells from the detailed molecular machinery...
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A modular systems biology analysis of cell cycle entrance into S-phase
A modular systems biology approach to the study of the cell cycle of the budding yeast Saccharomyces cerevisiae is presented. Literature on the...
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What is systems biology? From genes to function and back
The essence of the grand contributions of physiology and molecular biology to biology is discussed in relation to what may be needed to understand...
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Modeling the E. coli cell: The need for computing, cooperation, and consortia
Escherichia coli K-12 is an ideal test bed for pushing forward the limits of our ability to understand cellular systems through computational...
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Molecular responses of higher plants to dehydration
A massive amount of data has been accumulating on the molecular responses of plants to water deficit. In plants, dehydration activates a protective...