Search
Search Results
-
m1A demethylase Alkbh3 regulates neurogenesis through m1A demethylation of Mmp15 mRNA
BackgroundN 1 -Methyladenosine (m 1 A) is an abundant modification of transcripts regulating mRNA structure and translation efficiency. However, the...
-
SUMOylation of nuclear receptor Nor1/NR4A3 coordinates microtubule cytoskeletal dynamics and stability in neuronal cells
BackgroundNor1/NR4A3 is a member of the NR4A subfamily of nuclear receptors that play essential roles in regulating gene expression related to...
-
Where do Harris’ Checkerspots Lay their Eggs and what are the Consequences?
Where a female lays her eggs has strong implications for the survival of her offspring, an impetus that takes on particular significance for species...
-
Taxonomic diversity and environmental tolerance of cultivable extremophilic bacteria from a high-altitude meltwater pond on Ojos del Salado (Chile)
Earth harbors unique environments where only microorganisms adapted to extreme conditions, known as extremophiles, can survive. This study focused on...
-
Differences in spatiotemporal brain network dynamics of Montessori and traditionally schooled students
Across development, experience has a strong impact on the way we think and adapt. School experience affects academic and social-emotional outcomes,...
-
The Structure of the LysR-type Transcriptional Regulator, CysB, Bound to the Inducer, N-acetylserine
In Escherichia coli and Salmonella typhimurium , cysteine biosynthesis requires the products of 20 or more cys genes co-ordinately regulated by CysB....
-
Modulating social learning-induced evaluation updating during human sleep
People often change their evaluations upon learning about their peers’ evaluations, i.e., social learning. Given sleep’s vital role in consolidating...
-
The impact of premature birth on auditory-visual processes in very preterm schoolchildren
Interactions between stimuli from different sensory modalities and their integration are central to daily life, contributing to improved perception....
-
Temporal changes in the morphological and microbial diversity of biofilms on the surface of a submerged stone in the Danube River
Epilithic biofilms are ubiquitous in large river environments and are crucial for biogeochemical processes, but their community structures and...
-
New advances in drug development for metabolic dysfunction-associated diseases and alcohol-associated liver disease
Metabolic disorders are currently threatening public health worldwide. Discovering new targets and develo** promising drugs will reduce the global...
-
Investigation of in vitro biological activity of young Hordeum vulgare leaf in correlation with its bioactive compounds
Young shoots of cereals are widely regarded as superfoods with health benefits attributed to their potential antioxidant activity and...
-
PEGylation renders carnosine resistant to hydrolysis by serum carnosinase and increases renal carnosine levels
Carnosine’s protective effect in rodent models of glycoxidative stress have provided a rational for translation of these findings in therapeutic...
-
Decoding the role of DNA methylation in allergic diseases: from pathogenesis to therapy
Allergic diseases, characterized by a broad spectrum of clinical manifestations and symptoms, encompass a significant category of IgE-mediated atopic...
-
NOX4-mediated astrocyte ferroptosis in Alzheimer’s disease
This study investigates NADPH oxidase 4 (NOX4) involvement in iron-mediated astrocyte cell death in Alzheimer’s Disease (AD) using single-cell...
-
Analysis of proteins in the light of mutations
Proteins have evolved through mutations—amino acid substitutions—since life appeared on Earth, some 10 9 years ago. The study of these phenomena has...
-
Taking another look at intelligence and personality using an eye-tracking approach
Intelligence and personality are both key drivers of learning. This study extends prior research on intelligence and personality by adopting a...
-
Entry of ZSWIM4 to the nucleus is crucial for its inhibition of KIT and BMAL1 in gastrointestinal stromal tumors
BackgroundZinc finger SWIM-type containing 4 (ZSWIM4) is a zinc finger protein with its function largely uncharacterized. In this study, we aimed to...
-
Generation and transcriptomic characterization of MIR137 knockout miniature pig model for neurodevelopmental disorders
BackgroundNeurodevelopmental disorders (NDD), such as autism spectrum disorders (ASD) and intellectual disorders (ID), are highly debilitating...
-
Microvascular destabilization and intricated network of the cytokines in diabetic retinopathy: from the perspective of cellular and molecular components
Microvascular destabilization is the primary cause of the inner blood-retinal barrier (iBRB) breakdown and increased vascular leakage in diabetic...
