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The human Werner Syndrome as a model system for aging
The aging process is one of the most challenging biological pathways to understand. Applications of model systems for aging have contributed... -
Aging and mitochondrial dysfunction in the filamentous fungus Podospora anserina
In the filamentous fungus Podospora anserina, mitochondria play a paramount role in life span control and aging. During aging, these organelles... -
Aging and the programmed death phenomena
Biochemical mechanisms of the programmed death phenomena are considered at levels of unicellular organisms, mitochondria, cells, groups of cells, and... -
Introduction: Regulatory processes, an emerging feature in intracellular membrane traffic
The subject of this volume is the molecular mechanism of the intracellular membrane trafficking, a central eukaryotic cell biological process. In the... -
Functions of Rab GTPases in organelle biogenesis
Rab GTPases regulate diverse aspects of the biogenesis of secretory and endocytic organelles. The conformational changes that accompany GTP binding... -
Regulation of SNARE assembly by protein phosphorylation
Protein phosphorylation is emerging as an important regulatory mechanism that controls the secretory pathway. It enables coupling between the... -
Molecular mechanisms in clathrin-mediated membrane budding
Clathrin-coated vesicles (CCVs) form at the plasma membrane where they select cargo for endocytic entry into cells. CCVs also form at the trans-Golgi... -
Tethering proteins in membrane traffic
In eukaryotic cells, protein secretion and the transport of materials between membrane-bounded organelles require efficient and accurate delivery of... -
Regulation of exocytotic events by centrosome-analogous structures
Centrosomes, spindle pole bodies, and related structures, generally termed microtubule organising centres (MTOCs; Pickett-Heaps 1969), are best... -
Energy metabolism, anti-oxidant defense and aging in Caenorhabditis elegans
Food restriction and impaired gene function by mutation or RNAi treatment can extend the lifespan of Caenorhabditis elegans considerably. In contrast... -
Do green plants age, and if so, how?
Time-dependent ageing-like processes in green plants are discussed and compared to gerontological changes in animals and other organisms. The... -
Conditional senescence in prokaryotes
Bacteria are immortal in the sense that their capacity for reproduction appears limitless as long as the environment supports growth. However, this... -
Regulating membrane curvature
Membranes of living cells are subject to a variety of shape changes. Membrane deformation is essential for cell division, locomotion, organelle... -
Yeast as a model for ageing and apoptosis research
Apoptosis is a form of programmed cell death with a crucial role in health and disease in metazoans. Recent findings demonstrate the existence of an... -
Mammalian and bird aging, oxygen radicals, and restricted feeding
In this chapter, the relationship of aging with oxidative stress is reviewed. Endogenous tissue antioxidants do not determine aging because they... -
Role of subcytotoxic stress in tissue ageing
Most commonly stress-induced premature senescence (SIPS) is defined as the long-term effects of subcytotoxic stress on proliferative cell types,... -
Mitochondria, metabolism, and aging in yeast
Quantitative and qualitative changes in metabolism take place when the lifespan is extended in yeast either by genetic or nutritional manipulation.... -
Phosphoinositides and membrane traffic in health and disease
The phosphorylated derivatives of phosphatidylinositol (PtdIns) are collectively known as the polyphosphoinositides (PIs) and they were originally... -
The function of Sec1/Munc18 proteins – Solution of the mystery in sight?
Members of the Sec1/Munc18 (SM) protein family form a central part of the machinery responsible for transport vesicle docking and fusion. Their... -
Naturalized alien flora of Uzbekistan: species richness, origin and habitats
This is the first study providing an up-to-date account of the alien flora in Uzbekistan and analyzing the relationship between the invasion status...