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Human Microplastics Exposure and Potential Health Risks to Target Organs by Different Routes: A Review
Purpose of ReviewMicroplastics in the environment enter the human body through diet, drinking water, and air inhalation. The widespread detection of...
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Role of microbes, metabolites and effector compounds in host–microbiota interaction: a pharmacological outlook
Microbial cells react with intestinal surfaces and produce enzymes and metabolites that influence human health, host metabolism and immunity. Gut...
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Application of Mutagenesis and Genome Editing in Crop Plants
Mutagenesis and genome editing has emerged as a substitute to traditional plant breeding and transgenics for crop improvement and hence ensure...
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Consideration of pathways for immunotoxicity of per- and polyfluoroalkyl substances (PFAS)
BackgroundPer- and polyfluoroalkyl substances (PFAS) are of public health concern, because of their ubiquitous and extremely persistent occurrence,...
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Fipronil exposure compromises respiration and damages the Malpighian tubules of the stingless bee Partamona helleri Friese (Hymenoptera: Apidae)
Fipronil has been widely used in agriculture and forestry in Brazil to control several pests. However, this insecticide may be hazardous to...
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Histological Biomarkers and Protein Expression in Hyphessobrycon eques Fish Exposed to Atrazine
Pesticides are one of the main sources of pollution on the planet, affecting different environments. The aim of the study was to evaluate the chronic...
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Blocking prostanoid receptors switches on multiple immune responses and cascades of inflammatory signaling against larval stages in snail fever
Schistosomiasis, also known as snail fever or bilharziasis, is a worm infection caused by trematode called schistosomes that affects humans and...
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Targeting NLRP3 inflammasome as a chief instigator of obesity, contributing to local adipose tissue inflammation and insulin resistance
Inflammasome activity plays a vital role in various non-microbial disease states correlated with prolonged inflammation. NLRP3 inflammasome function...
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Silver nanoparticles induced testicular damage targeting NQO1 and APE1 dysregulation, apoptosis via Bax/Bcl-2 pathway, fibrosis via TGF-β/α-SMA upregulation in rats
In medicine, silver nanoparticles (AgNPs) are employed often. They do, however, have negative impacts, particularly on the reproductive organs. This...
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Plant-Environment Interactions: The Dynamics of the Skill and Beyond
Plant’s dynamic phenotypes are shaped by the interactions between the plant and its environment. To advance the study of plants and their...
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Microbes, Their Metabolites, and Effector Molecules: A Pharmacological Perspective for Host-Microbiota Interaction
The human microbiota and probiotics are key players to modulate human health. Microbial cells, as a whole, have either been known to physically react...
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Emergence of nutrigenomics and dietary components as a complementary therapy in cancer prevention
Cancer is an illness characterized by abnormal cell development and the capability to infiltrate or spread to rest of the body. A tumor is the term...
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Characterization of lymphocyte subsets and intestinal short-chain fatty acids in benzene-induced immunosuppressive mice
Exposure to benzene causes immunosuppression, but the mechanism has not been clarified. In this study, mice were subcutaneously injected with...
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Use of Genetic Engineering Approach in Bioremediation of Wastewater
The principles of genetic engineering led to unlocking the door to many possibilities, expanding its application into several fields of life...
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Nanotechnology and CRISPR/Cas9 system for sustainable agriculture
The clustered regularly interspaced short palindromic repeats (CRISPR-Cas9), a genome editing tool, has gained a tremendous position due to its...
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EGFR and Hippo signaling pathways are involved in organophosphate esters–induced proliferation and migration of triple-negative breast cancer cells
The widespread application of organophosphate flame retardants has led to pervasive exposure to organophosphate esters (OPEs), prompting considerable...
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Overview of deltamethrin residues and toxic effects in the global environment
Pyrethroids are synthetic organic insecticides. Deltamethrin, as one of the pyrethroids, has high insecticidal activity against pests and parasites...
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Human Health Effects of Chronic Cadmium Exposure
Cadmium (Cd) is a hazardous unnecessary transition metal that is harmful to people and animals. Cadmium is naturally prevalent in the environment and...
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Impact of plant extracts on hepatic redox metabolism upon lead exposure: a systematic review of preclinical in vivo evidence
The liver is a central target organ of heavy metals toxicity, and secondary metabolites of several plant species are suggested to attenuate lead...
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Increased Intestinal Permeability: An Avenue for the Development of Autoimmune Disease?
The intestinal epithelium acts as the first line of defence against pathogens present in the lumen of the gastrointestinal tract. The epithelium is...
